Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158686044> ?p ?o ?g. }
- W2158686044 endingPage "501" @default.
- W2158686044 startingPage "489" @default.
- W2158686044 abstract "Epileptic seizures in patients with malignancies usually occur as a consequence of brain metastases from systemic cancer or the presence of a primary brain tumor. Other less-frequent causes include metabolic disorders such as electrolyte abnormalities, hypoglycemia, hypoxia and liver failure, paraneoplastic encephalitis, leptomeningeal carcinomatosis, side effects of certain chemotherapeutic agents, central nervous system infections, and pre-existing epilepsy.We reviewed all published literature in the English language regarding the use of antiepileptic drugs in patients with cancer.In patients with brain metastases or primary brain tumors that had never experienced seizures, prophylactic anticonvulsant treatment is justified only for a period up to 6 months postoperatively after surgical excision of a cerebral tumor, since approximately half of the patients will never develop seizures and the anti-epileptic drugs may cause toxicity and interactions with antineoplastic therapies. For brief prophylaxis, newer antiepileptic drugs such as levetiracetam and oxcarbazepine are superior to older agents like phenytoin. In patients with a malignancy and seizures, certain antiepileptic drugs that express tumor inhibitory properties should be used such as valproic acid and levetiracetam, followed by oxcarbazepine and topiramate that exhibit good tolerance, efficient seizure control and absence of significant interactions with the chemotherapy.Future clinical trials in patients with cancer and epilepsy should focus on combinations of chemotherapeutic interventions with antiepileptic drugs that demonstrate antineoplastic activities." @default.
- W2158686044 created "2016-06-24" @default.
- W2158686044 creator A5006364227 @default.
- W2158686044 creator A5024359683 @default.
- W2158686044 creator A5080426084 @default.
- W2158686044 date "2011-02-09" @default.
- W2158686044 modified "2023-10-18" @default.
- W2158686044 title "Epilepsy in the cancer patient" @default.
- W2158686044 cites W1570008378 @default.
- W2158686044 cites W1825773626 @default.
- W2158686044 cites W1964297356 @default.
- W2158686044 cites W1966419081 @default.
- W2158686044 cites W1968671346 @default.
- W2158686044 cites W1969159860 @default.
- W2158686044 cites W1973250049 @default.
- W2158686044 cites W1974279272 @default.
- W2158686044 cites W1978194803 @default.
- W2158686044 cites W1982350642 @default.
- W2158686044 cites W1984025642 @default.
- W2158686044 cites W1985855938 @default.
- W2158686044 cites W1993808734 @default.
- W2158686044 cites W1997425755 @default.
- W2158686044 cites W1999004349 @default.
- W2158686044 cites W2000431894 @default.
- W2158686044 cites W2005018772 @default.
- W2158686044 cites W2006639452 @default.
- W2158686044 cites W2008821460 @default.
- W2158686044 cites W2013772421 @default.
- W2158686044 cites W2016312141 @default.
- W2158686044 cites W2021657776 @default.
- W2158686044 cites W2024412571 @default.
- W2158686044 cites W2025024001 @default.
- W2158686044 cites W2028680985 @default.
- W2158686044 cites W2030459294 @default.
- W2158686044 cites W2033345378 @default.
- W2158686044 cites W2034523703 @default.
- W2158686044 cites W2036178040 @default.
- W2158686044 cites W2037433948 @default.
- W2158686044 cites W2040259543 @default.
- W2158686044 cites W2040851668 @default.
- W2158686044 cites W2041750578 @default.
- W2158686044 cites W2044931150 @default.
- W2158686044 cites W2052129770 @default.
- W2158686044 cites W2053406012 @default.
- W2158686044 cites W2054086992 @default.
- W2158686044 cites W2055854830 @default.
- W2158686044 cites W2059367843 @default.
- W2158686044 cites W2063862684 @default.
- W2158686044 cites W2064923219 @default.
- W2158686044 cites W2065018463 @default.
- W2158686044 cites W2069017740 @default.
- W2158686044 cites W2069987842 @default.
- W2158686044 cites W2071314439 @default.
- W2158686044 cites W2076398887 @default.
- W2158686044 cites W2077125518 @default.
- W2158686044 cites W2080269410 @default.
- W2158686044 cites W2081142042 @default.
- W2158686044 cites W2087107086 @default.
- W2158686044 cites W2091273536 @default.
- W2158686044 cites W2091717377 @default.
- W2158686044 cites W2095067006 @default.
- W2158686044 cites W2097722582 @default.
- W2158686044 cites W2098091937 @default.
- W2158686044 cites W2098249941 @default.
- W2158686044 cites W2105100844 @default.
- W2158686044 cites W2108096367 @default.
- W2158686044 cites W2110153172 @default.
- W2158686044 cites W2111042597 @default.
- W2158686044 cites W2111878666 @default.
- W2158686044 cites W2117691193 @default.
- W2158686044 cites W2123001230 @default.
- W2158686044 cites W2123836229 @default.
- W2158686044 cites W2127801604 @default.
- W2158686044 cites W2131101712 @default.
- W2158686044 cites W2131496660 @default.
- W2158686044 cites W2138342312 @default.
- W2158686044 cites W2141976464 @default.
- W2158686044 cites W2146370779 @default.
- W2158686044 cites W2148232503 @default.
- W2158686044 cites W2152840183 @default.
- W2158686044 cites W2158031796 @default.
- W2158686044 cites W2159466690 @default.
- W2158686044 cites W2160421126 @default.
- W2158686044 cites W2160893557 @default.
- W2158686044 cites W2163642916 @default.
- W2158686044 cites W2165048771 @default.
- W2158686044 cites W2166094810 @default.
- W2158686044 cites W2395359805 @default.
- W2158686044 cites W2409298471 @default.
- W2158686044 cites W4245902975 @default.
- W2158686044 cites W83394720 @default.
- W2158686044 doi "https://doi.org/10.1007/s00280-011-1569-0" @default.
- W2158686044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21305288" @default.
- W2158686044 hasPublicationYear "2011" @default.
- W2158686044 type Work @default.
- W2158686044 sameAs 2158686044 @default.
- W2158686044 citedByCount "42" @default.
- W2158686044 countsByYear W21586860442012 @default.