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- W2158686901 abstract "The identification of genetic mechanisms underlying evolutionary change is critical to our understanding of natural diversity, but is presently limited by the lack of genetic and genomic resources for most species. Here, we present a new comparative genomic approach that can be applied to a broad taxonomic sampling of nonmodel species to investigate the genetic basis of evolutionary change. Using our analysis pipeline, we show that duplication and divergence of fgfr1a is correlated with the reduction of scales within fishes of the genus Phoxinellus. As a parallel genetic mechanism is observed in scale-reduction within independent lineages of cypriniforms, our finding exposes significant developmental constraint guiding morphological evolution. In addition, we identified fixed variation in fgf20a within Phoxinellus and demonstrated that combinatorial loss-of-function of fgfr1a and fgf20a within zebrafish phenocopies the evolved scalation pattern. Together, these findings reveal epistatic interactions between fgfr1a and fgf20a as a developmental mechanism regulating skeletal variation among fishes." @default.
- W2158686901 created "2016-06-24" @default.
- W2158686901 creator A5002088426 @default.
- W2158686901 creator A5005479991 @default.
- W2158686901 creator A5034613333 @default.
- W2158686901 creator A5051035625 @default.
- W2158686901 creator A5086394507 @default.
- W2158686901 date "2015-10-08" @default.
- W2158686901 modified "2023-10-18" @default.
- W2158686901 title "Parallelism and Epistasis in Skeletal Evolution Identified through Use of Phylogenomic Mapping Strategies" @default.
- W2158686901 cites W1521650410 @default.
- W2158686901 cites W1548753322 @default.
- W2158686901 cites W1963957860 @default.
- W2158686901 cites W1964106562 @default.
- W2158686901 cites W1968759975 @default.
- W2158686901 cites W1969528840 @default.
- W2158686901 cites W1975533499 @default.
- W2158686901 cites W1980740976 @default.
- W2158686901 cites W1980959426 @default.
- W2158686901 cites W1985207433 @default.
- W2158686901 cites W1991943452 @default.
- W2158686901 cites W1993919323 @default.
- W2158686901 cites W1994344348 @default.
- W2158686901 cites W1995828718 @default.
- W2158686901 cites W1996760543 @default.
- W2158686901 cites W1997627685 @default.
- W2158686901 cites W1998984510 @default.
- W2158686901 cites W1999057382 @default.
- W2158686901 cites W1999860971 @default.
- W2158686901 cites W2004798786 @default.
- W2158686901 cites W2010746507 @default.
- W2158686901 cites W2015118259 @default.
- W2158686901 cites W2029809033 @default.
- W2158686901 cites W2031911789 @default.
- W2158686901 cites W2032906301 @default.
- W2158686901 cites W2043512838 @default.
- W2158686901 cites W2048319852 @default.
- W2158686901 cites W2050546910 @default.
- W2158686901 cites W2054848341 @default.
- W2158686901 cites W2055043387 @default.
- W2158686901 cites W2055044898 @default.
- W2158686901 cites W2055653287 @default.
- W2158686901 cites W2057587811 @default.
- W2158686901 cites W2062131670 @default.
- W2158686901 cites W2062935524 @default.
- W2158686901 cites W2066261007 @default.
- W2158686901 cites W2067435927 @default.
- W2158686901 cites W2076189890 @default.
- W2158686901 cites W2076793571 @default.
- W2158686901 cites W2081778808 @default.
- W2158686901 cites W2083653513 @default.
- W2158686901 cites W2085214224 @default.
- W2158686901 cites W2085225329 @default.
- W2158686901 cites W2086253706 @default.
- W2158686901 cites W2089806726 @default.
- W2158686901 cites W2091851394 @default.
- W2158686901 cites W2096819448 @default.
- W2158686901 cites W2100062780 @default.
- W2158686901 cites W2101103652 @default.
- W2158686901 cites W2101341738 @default.
- W2158686901 cites W2102502076 @default.
- W2158686901 cites W2103546861 @default.
- W2158686901 cites W2103914320 @default.
- W2158686901 cites W2105381419 @default.
- W2158686901 cites W2105896832 @default.
- W2158686901 cites W2106578986 @default.
- W2158686901 cites W2108234281 @default.
- W2158686901 cites W2112457283 @default.
- W2158686901 cites W2113104616 @default.
- W2158686901 cites W2114030115 @default.
- W2158686901 cites W2118514687 @default.
- W2158686901 cites W2122553379 @default.
- W2158686901 cites W2123707618 @default.
- W2158686901 cites W2126059070 @default.
- W2158686901 cites W2132926880 @default.
- W2158686901 cites W2133212095 @default.
- W2158686901 cites W2138697615 @default.
- W2158686901 cites W2144690533 @default.
- W2158686901 cites W2146127418 @default.
- W2158686901 cites W2149594557 @default.
- W2158686901 cites W2152075687 @default.
- W2158686901 cites W2152156139 @default.
- W2158686901 cites W2154770881 @default.
- W2158686901 cites W2157530188 @default.
- W2158686901 cites W2163713616 @default.
- W2158686901 cites W2166265186 @default.
- W2158686901 cites W2167213627 @default.
- W2158686901 cites W2167852161 @default.
- W2158686901 cites W2171193618 @default.
- W2158686901 cites W2171835981 @default.
- W2158686901 cites W2181578959 @default.
- W2158686901 cites W2319724751 @default.
- W2158686901 cites W4229487902 @default.
- W2158686901 cites W4236236547 @default.
- W2158686901 cites W4255757934 @default.
- W2158686901 doi "https://doi.org/10.1093/molbev/msv208" @default.
- W2158686901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5009992" @default.
- W2158686901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26452532" @default.