Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158707218> ?p ?o ?g. }
- W2158707218 endingPage "S99" @default.
- W2158707218 startingPage "S52" @default.
- W2158707218 abstract "The aryl alkyl alcohol (AAA) fragrance ingredients are a diverse group of chemical structures with similar metabolic and toxicity profiles. The AAA fragrances demonstrate low acute and subchronic dermal and oral toxicity. No carcinogenicity in rats or mice was observed in 2-year chronic testing of benzyl alcohol or α-methylbenzyl alcohol; the latter did induce species and gender-specific renal adenomas in male rats at the high dose. There was no to little genotoxicity, mutagenicity, or clastogenicity in the mutagenic in vitro bacterial assays, and in vitro mammalian cell assays. All in vivo micronucleus assays were negative. NOAELs for maternal and developmental toxicity are far in excess of current human exposure levels. At concentrations likely to be encountered by consumers, AAA fragrance ingredients are non-irritating to the skin. The potential for eye irritation is minimal. With the exception of benzyl alcohol and to a lesser extent phenethyl and 2-phenoxyethyl AAA alcohols, human sensitization studies, diagnostic patch tests and human induction studies, indicate that AAA fragrance ingredients generally have no or low sensitization potential. Available data indicate that the potential for photosensitization is low. It is concluded that these materials would not present a safety concern at current levels of use as fragrance ingredients." @default.
- W2158707218 created "2016-06-24" @default.
- W2158707218 creator A5012629222 @default.
- W2158707218 creator A5025432085 @default.
- W2158707218 creator A5035988449 @default.
- W2158707218 creator A5039691029 @default.
- W2158707218 creator A5044522566 @default.
- W2158707218 creator A5049902752 @default.
- W2158707218 creator A5062581638 @default.
- W2158707218 creator A5074547704 @default.
- W2158707218 creator A5076875729 @default.
- W2158707218 creator A5080862260 @default.
- W2158707218 date "2012-09-01" @default.
- W2158707218 modified "2023-10-16" @default.
- W2158707218 title "A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients" @default.
- W2158707218 cites W131196824 @default.
- W2158707218 cites W1519859768 @default.
- W2158707218 cites W1856335405 @default.
- W2158707218 cites W194083756 @default.
- W2158707218 cites W1964345123 @default.
- W2158707218 cites W1964536301 @default.
- W2158707218 cites W1967332356 @default.
- W2158707218 cites W1967557721 @default.
- W2158707218 cites W1967643352 @default.
- W2158707218 cites W1967803894 @default.
- W2158707218 cites W1968313737 @default.
- W2158707218 cites W1969767370 @default.
- W2158707218 cites W1973568948 @default.
- W2158707218 cites W1973771710 @default.
- W2158707218 cites W1974487940 @default.
- W2158707218 cites W1976120765 @default.
- W2158707218 cites W1976362295 @default.
- W2158707218 cites W1976440432 @default.
- W2158707218 cites W1977363918 @default.
- W2158707218 cites W1982094472 @default.
- W2158707218 cites W1982381849 @default.
- W2158707218 cites W1982404531 @default.
- W2158707218 cites W1982806147 @default.
- W2158707218 cites W1985293825 @default.
- W2158707218 cites W1987595393 @default.
- W2158707218 cites W1988281039 @default.
- W2158707218 cites W1990082885 @default.
- W2158707218 cites W1991256908 @default.
- W2158707218 cites W1991432039 @default.
- W2158707218 cites W1992193564 @default.
- W2158707218 cites W1994900135 @default.
- W2158707218 cites W1995157824 @default.
- W2158707218 cites W1997747008 @default.
- W2158707218 cites W2002765670 @default.
- W2158707218 cites W2002911362 @default.
- W2158707218 cites W2003350839 @default.
- W2158707218 cites W2005087900 @default.
- W2158707218 cites W2006478072 @default.
- W2158707218 cites W2006938400 @default.
- W2158707218 cites W2010134352 @default.
- W2158707218 cites W2012836723 @default.
- W2158707218 cites W2014263622 @default.
- W2158707218 cites W2014433035 @default.
- W2158707218 cites W2017201923 @default.
- W2158707218 cites W2017928004 @default.
- W2158707218 cites W2018690301 @default.
- W2158707218 cites W2019555568 @default.
- W2158707218 cites W2020197561 @default.
- W2158707218 cites W2020488009 @default.
- W2158707218 cites W2021215361 @default.
- W2158707218 cites W2021402462 @default.
- W2158707218 cites W2023083459 @default.
- W2158707218 cites W2023306098 @default.
- W2158707218 cites W2024861506 @default.
- W2158707218 cites W2026743557 @default.
- W2158707218 cites W2028517375 @default.
- W2158707218 cites W2028970418 @default.
- W2158707218 cites W2029016338 @default.
- W2158707218 cites W2029078743 @default.
- W2158707218 cites W2029359727 @default.
- W2158707218 cites W2029607484 @default.
- W2158707218 cites W2030706292 @default.
- W2158707218 cites W2032201472 @default.
- W2158707218 cites W2032844391 @default.
- W2158707218 cites W2036193434 @default.
- W2158707218 cites W2037290555 @default.
- W2158707218 cites W2037369355 @default.
- W2158707218 cites W2037603351 @default.
- W2158707218 cites W2037888311 @default.
- W2158707218 cites W2038514050 @default.
- W2158707218 cites W2042305818 @default.
- W2158707218 cites W2042852438 @default.
- W2158707218 cites W2043081863 @default.
- W2158707218 cites W2043220416 @default.
- W2158707218 cites W2045534986 @default.
- W2158707218 cites W2048227489 @default.
- W2158707218 cites W2049227815 @default.
- W2158707218 cites W2050645783 @default.
- W2158707218 cites W2053450202 @default.
- W2158707218 cites W2053720015 @default.
- W2158707218 cites W2060309275 @default.
- W2158707218 cites W2063555194 @default.
- W2158707218 cites W2063986444 @default.