Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158727199> ?p ?o ?g. }
- W2158727199 endingPage "2682" @default.
- W2158727199 startingPage "2676" @default.
- W2158727199 abstract "We have previously employed an intercellular spreading strategy using herpes simplex virus type 1 (HSV-1) VP22 protein to enhance DNA vaccine potency because DNA vaccines lack the intrinsic ability to amplify in cells. Recently, studies have demonstrated that the protein encoded by UL49 of Marek's disease virus type 1 (MDV-1) exhibits some degree of homology to the HSV-1 VP22 protein and features the property of intercellular transport. We therefore generated a DNA vaccine encoding MDV-1 VP22 linked to a model antigen, human papillomavirus type 16 E7. We demonstrated that compared with mice vaccinated with DNA encoding wild-type E7, mice vaccinated with MDV-1 VP22/E7 DNA exhibited a significant increase in number of gamma-interferon-secreting, E7-specific CD8(+)-T-cell precursors as well as stronger tumor prevention and treatment effects. Furthermore, our data indicated that the antitumor effect was CD8 dependent. These results suggested that the development of vaccines encoding VP22 fused to a target antigen might be a promising strategy for improving DNA vaccine potency." @default.
- W2158727199 created "2016-06-24" @default.
- W2158727199 creator A5006924305 @default.
- W2158727199 creator A5012532553 @default.
- W2158727199 creator A5049674356 @default.
- W2158727199 creator A5062803843 @default.
- W2158727199 creator A5064814823 @default.
- W2158727199 creator A5090305166 @default.
- W2158727199 date "2002-03-15" @default.
- W2158727199 modified "2023-10-18" @default.
- W2158727199 title "Improving DNA Vaccine Potency by Linking Marek's Disease Virus Type 1 VP22 to an Antigen" @default.
- W2158727199 cites W1514540900 @default.
- W2158727199 cites W1560116787 @default.
- W2158727199 cites W1566505170 @default.
- W2158727199 cites W1600662889 @default.
- W2158727199 cites W1612135387 @default.
- W2158727199 cites W1751493734 @default.
- W2158727199 cites W1850598717 @default.
- W2158727199 cites W1898098760 @default.
- W2158727199 cites W1949342640 @default.
- W2158727199 cites W1976822357 @default.
- W2158727199 cites W1977959119 @default.
- W2158727199 cites W1978146796 @default.
- W2158727199 cites W1983062261 @default.
- W2158727199 cites W2014488064 @default.
- W2158727199 cites W2018646351 @default.
- W2158727199 cites W2028303536 @default.
- W2158727199 cites W2041805971 @default.
- W2158727199 cites W2062078150 @default.
- W2158727199 cites W2066833587 @default.
- W2158727199 cites W2082089723 @default.
- W2158727199 cites W2092128665 @default.
- W2158727199 cites W2092438678 @default.
- W2158727199 cites W2103053970 @default.
- W2158727199 cites W2103423829 @default.
- W2158727199 cites W2105558735 @default.
- W2158727199 cites W2112333290 @default.
- W2158727199 cites W2120403825 @default.
- W2158727199 cites W2132568167 @default.
- W2158727199 cites W2160551926 @default.
- W2158727199 cites W2172177489 @default.
- W2158727199 cites W2178523848 @default.
- W2158727199 cites W2241278927 @default.
- W2158727199 cites W2333406873 @default.
- W2158727199 cites W4235081779 @default.
- W2158727199 cites W4241169271 @default.
- W2158727199 cites W4249838284 @default.
- W2158727199 doi "https://doi.org/10.1128/jvi.76.6.2676-2682.2002" @default.
- W2158727199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/135982" @default.
- W2158727199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11861834" @default.
- W2158727199 hasPublicationYear "2002" @default.
- W2158727199 type Work @default.
- W2158727199 sameAs 2158727199 @default.
- W2158727199 citedByCount "83" @default.
- W2158727199 countsByYear W21587271992012 @default.
- W2158727199 countsByYear W21587271992013 @default.
- W2158727199 countsByYear W21587271992015 @default.
- W2158727199 countsByYear W21587271992016 @default.
- W2158727199 countsByYear W21587271992017 @default.
- W2158727199 countsByYear W21587271992018 @default.
- W2158727199 countsByYear W21587271992019 @default.
- W2158727199 countsByYear W21587271992022 @default.
- W2158727199 crossrefType "journal-article" @default.
- W2158727199 hasAuthorship W2158727199A5006924305 @default.
- W2158727199 hasAuthorship W2158727199A5012532553 @default.
- W2158727199 hasAuthorship W2158727199A5049674356 @default.
- W2158727199 hasAuthorship W2158727199A5062803843 @default.
- W2158727199 hasAuthorship W2158727199A5064814823 @default.
- W2158727199 hasAuthorship W2158727199A5090305166 @default.
- W2158727199 hasBestOaLocation W21587271991 @default.
- W2158727199 hasConcept C147483822 @default.
- W2158727199 hasConcept C153911025 @default.
- W2158727199 hasConcept C154317977 @default.
- W2158727199 hasConcept C159047783 @default.
- W2158727199 hasConcept C167508917 @default.
- W2158727199 hasConcept C167672396 @default.
- W2158727199 hasConcept C202751555 @default.
- W2158727199 hasConcept C203014093 @default.
- W2158727199 hasConcept C2522874641 @default.
- W2158727199 hasConcept C2777852405 @default.
- W2158727199 hasConcept C2780801004 @default.
- W2158727199 hasConcept C2781196997 @default.
- W2158727199 hasConcept C54355233 @default.
- W2158727199 hasConcept C552990157 @default.
- W2158727199 hasConcept C57992300 @default.
- W2158727199 hasConcept C86803240 @default.
- W2158727199 hasConceptScore W2158727199C147483822 @default.
- W2158727199 hasConceptScore W2158727199C153911025 @default.
- W2158727199 hasConceptScore W2158727199C154317977 @default.
- W2158727199 hasConceptScore W2158727199C159047783 @default.
- W2158727199 hasConceptScore W2158727199C167508917 @default.
- W2158727199 hasConceptScore W2158727199C167672396 @default.
- W2158727199 hasConceptScore W2158727199C202751555 @default.
- W2158727199 hasConceptScore W2158727199C203014093 @default.
- W2158727199 hasConceptScore W2158727199C2522874641 @default.
- W2158727199 hasConceptScore W2158727199C2777852405 @default.
- W2158727199 hasConceptScore W2158727199C2780801004 @default.
- W2158727199 hasConceptScore W2158727199C2781196997 @default.