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- W2158749368 abstract "Growth of Saccharomyces cerevisiae on D-glucono-δ-lactone (δgl) was found to be associated with a specific coordinate induction of the synthesis of two enzymes of the oxidative pentose phosphate pathway – 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase – together with that of a third enzyme, gluconokinase. The gnd1 mutation, responsible for an approximately 80% loss of 6-phosphogluconate dehydrogenase activity and the inability of the cells to grow on δgl, completely abolished the induction of all three enzymes, while the gnd2 mutation affected this only partially. One class of gnd1 revertants, selected for growth on δgl, was found to have recovered normal dehydrogenase activity and the ability to synthesize the three enzymes when induced by δgl. Another class of δgl-positive revertants possessed constitutively elevated levels of gluconokinase. In contrast, glucose-positive revertants of gnd1, with restored constitutive dehydrogenase activity, continued to remain deficient in induction of the three enzymes and also failed to grow on δgl. Induction of 6-phosphogluconate dehydrogenase activity was associated with increased transcription of the gene coding for the major isoenzyme; the transcript remained undetectable in the gnd1 mutant. Induction of these specific enzymes thus appears to be essential for growth of S. cerevisiae on δgl." @default.
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- W2158749368 date "1992-09-01" @default.
- W2158749368 modified "2023-10-16" @default.
- W2158749368 title "Induction of specific enzymes of the oxidative pentose phosphate pathway by glucono- -lactone in Saccharomyces cerevisiae" @default.
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- W2158749368 doi "https://doi.org/10.1099/00221287-138-9-1865" @default.
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