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- W2158766357 abstract "In this work the relevance of a systematic replacement of peptide-bonds on the Mastoparan MP-8 antimicrobial peptide to afford 27 new pseudopeptide analogues is reported. Results allowed to determine that pseudopeptides ψ-38617 (INLKALAALAKd-[CH2NH]-RLL), ψ-38629(INLKAd-[CH2NH]-LAALAKRLL) and ψ-38630 (INLK-[CH2NH]-ALAALAKRLL), showed an enhanced anti gam-negative bacterial properties, regarding the native Mastoparan MP-8 peptide, but maintaining a comparable activity against gram-positive bacteria. In addition, specific performed modifications on MP-8 sequence led three new molecules that completely abolished the hemolytic activity of the parent MP-8 peptide. All obtained molecules possess a high stability profile when tested against a severe proteolytic attack." @default.
- W2158766357 created "2016-06-24" @default.
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- W2158766357 date "2013-01-01" @default.
- W2158766357 modified "2023-09-26" @default.
- W2158766357 title "Exploración estructural de perfiles de actividad antibacteriana y hemolítica de análogos no naturales del péptido antimicrobiano Mastoparán MP-8" @default.
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