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- W21587789 abstract "The first evidence that virus-specific CD8+ cytotoxic T lymphocytes (CTLs) are primary effectors in vivo came shortly after the discovery of major histo- compatibility complex (MHC)-restricted CD8+ CTL activity (Zinkernagel and Doherty 1974). Adoptive transfer of immune spleen cells from mice of MHC type A into A or (AxB) F1, but not B, virus-infected recipients caused massive inflammatory pathology (Doherty and Zinkernagel 1975; DOHERTY et al. 1976b) and acute elimination of the pathogen (BLANDEN et al. 1975a; Zinkernagel and Welsh 1976). This was repeated for situations in which A and B represented different MHC haplotypes or distinct allelic forms of class I MHC glycoproteins (Doherty and Zinkernagel 1975; Blanden et al. 1975b; Doherty et al. 1976a). The analysis was extended to H-2 mutant mice and, again, the spectrum of cross-reactivity for T cell effector function in vivo and CTL activity in vitro seemed to run in parallel (Doherty et al. 1976a; Zinkernagel and Doherty 1979)." @default.
- W21587789 created "2016-06-24" @default.
- W21587789 creator A5074692390 @default.
- W21587789 date "1996-01-01" @default.
- W21587789 modified "2023-10-16" @default.
- W21587789 title "Cytotoxic T Cell Effector and Memory Function in Viral Immunity" @default.
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- W21587789 doi "https://doi.org/10.1007/978-3-642-85208-4_1" @default.
- W21587789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8608712" @default.
- W21587789 hasPublicationYear "1996" @default.
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