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- W2158789992 abstract "To review salient basic research regarding physical exercise as a major protective factor against hippocampal degradation and to emphasize its relevance to humans.Recent mammalian and human research literature search and theoretical discussion.The cascade of cellular damages from oxidative stress, nitrosative stress and gluco-corticoid effects are cumulative and age related. Exercise training reduces oxidative stress, nitro-sative stress and improves neuroendocrine autoregulation which counteracts damages from stress- and age-related neuronal degeneration, brain ischemia and traumatic brain injury. Conversely, lack of exercise and motility restrictions are associated with increased vulnerability from oxidative stress, nitrosative stress and glucocorticoid excesses, all of which precede amyloid deposition and are fundamental in the cascade of events resulting in neuronal degradation, especially in the hippocampi.Despite the paucity of human research, basic animal models and clinical data overwhelmingly support the notion that exercise treatment is a major protective factor against neurodegeneration of varied etiologies. The final common pathway of degradation is clearly related to oxidative stress, nitrosative stress, glucocorticoid dysregulation, inflammation and amyloid deposition. We conclude that people prone to chronic distress, brain ischemia, brain trauma, and the aged are at increased risk for neurodegenerative diseases such as Alzheimer's. Exercise training may be a major protective factor but without clinical guidelines, its prescription and success with treatment adherence remain elusive." @default.
- W2158789992 created "2016-06-24" @default.
- W2158789992 creator A5013672978 @default.
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- W2158789992 date "2005-03-01" @default.
- W2158789992 modified "2023-10-18" @default.
- W2158789992 title "The Effect of Exercise on Hippocampal Integrity: Review of Recent Research" @default.
- W2158789992 cites W1061925755 @default.
- W2158789992 cites W1517525911 @default.
- W2158789992 cites W1850032865 @default.
- W2158789992 cites W1922689867 @default.
- W2158789992 cites W1965365265 @default.
- W2158789992 cites W1967939641 @default.
- W2158789992 cites W1971578308 @default.
- W2158789992 cites W1976031759 @default.
- W2158789992 cites W1977311786 @default.
- W2158789992 cites W1986751792 @default.
- W2158789992 cites W1988222703 @default.
- W2158789992 cites W1994498285 @default.
- W2158789992 cites W1995188451 @default.
- W2158789992 cites W1998316360 @default.
- W2158789992 cites W2001528301 @default.
- W2158789992 cites W2003463537 @default.
- W2158789992 cites W2003972991 @default.
- W2158789992 cites W2005170723 @default.
- W2158789992 cites W2009742165 @default.
- W2158789992 cites W2010312001 @default.
- W2158789992 cites W2010582215 @default.
- W2158789992 cites W2010909622 @default.
- W2158789992 cites W2011417221 @default.
- W2158789992 cites W2012403948 @default.
- W2158789992 cites W2018769094 @default.
- W2158789992 cites W2021551531 @default.
- W2158789992 cites W2023390598 @default.
- W2158789992 cites W2023503280 @default.
- W2158789992 cites W2027914056 @default.
- W2158789992 cites W2032054534 @default.
- W2158789992 cites W2033581744 @default.
- W2158789992 cites W2034758657 @default.
- W2158789992 cites W2039313723 @default.
- W2158789992 cites W2040072583 @default.
- W2158789992 cites W2044107164 @default.
- W2158789992 cites W2049638747 @default.
- W2158789992 cites W2064574532 @default.
- W2158789992 cites W2065219991 @default.
- W2158789992 cites W2065783253 @default.
- W2158789992 cites W2067856703 @default.
- W2158789992 cites W2068745164 @default.
- W2158789992 cites W2069422214 @default.
- W2158789992 cites W2069527370 @default.
- W2158789992 cites W2069666864 @default.
- W2158789992 cites W2071392303 @default.
- W2158789992 cites W2073786529 @default.
- W2158789992 cites W2084023315 @default.
- W2158789992 cites W2087638038 @default.
- W2158789992 cites W2093757589 @default.
- W2158789992 cites W2095621515 @default.
- W2158789992 cites W2100464372 @default.
- W2158789992 cites W2104004556 @default.
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- W2158789992 cites W2136742966 @default.
- W2158789992 cites W2136855986 @default.
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- W2158789992 cites W2142157411 @default.
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- W2158789992 cites W2156152760 @default.
- W2158789992 cites W2166687069 @default.
- W2158789992 cites W2168558282 @default.
- W2158789992 cites W2172106147 @default.
- W2158789992 cites W2334787351 @default.
- W2158789992 cites W4247950855 @default.
- W2158789992 cites W4254526183 @default.
- W2158789992 cites W4301237366 @default.
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- W2158789992 doi "https://doi.org/10.2190/hx7l-4b40-pqny-2a4p" @default.
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