Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158800145> ?p ?o ?g. }
- W2158800145 endingPage "190" @default.
- W2158800145 startingPage "178" @default.
- W2158800145 abstract "Adult neurogenesis persists in the subventricular zone and the dentate gyrus and can be induced upon central nervous system injury. However, the final contribution of newborn neurons to neuronal networks is limited. Here we show that in neural stem cells, stimulation of the “death receptor” CD95 does not trigger apoptosis but unexpectedly leads to increased stem cell survival and neuronal specification. These effects are mediated via activation of the Src/PI3K/AKT/mTOR signaling pathway, ultimately leading to a global increase in protein translation. Induction of neurogenesis by CD95 was further confirmed in the ischemic CA1 region, in the naive dentate gyrus, and after forced expression of CD95L in the adult subventricular zone. Lack of hippocampal CD95 resulted in a reduction in neurogenesis and working memory deficits. Following global ischemia, CD95-mediated brain repair rescued behavioral impairment. Thus, we identify the CD95/CD95L system as an instructive signal for ongoing and injury-induced neurogenesis." @default.
- W2158800145 created "2016-06-24" @default.
- W2158800145 creator A5003387515 @default.
- W2158800145 creator A5007401051 @default.
- W2158800145 creator A5009783365 @default.
- W2158800145 creator A5013217770 @default.
- W2158800145 creator A5029501668 @default.
- W2158800145 creator A5033642963 @default.
- W2158800145 creator A5034870531 @default.
- W2158800145 creator A5039985608 @default.
- W2158800145 creator A5041531993 @default.
- W2158800145 creator A5042901530 @default.
- W2158800145 creator A5053232413 @default.
- W2158800145 creator A5054868101 @default.
- W2158800145 creator A5061510256 @default.
- W2158800145 creator A5068548177 @default.
- W2158800145 creator A5069375338 @default.
- W2158800145 creator A5076983676 @default.
- W2158800145 creator A5078334004 @default.
- W2158800145 creator A5079495532 @default.
- W2158800145 creator A5079673431 @default.
- W2158800145 creator A5084018673 @default.
- W2158800145 creator A5086604397 @default.
- W2158800145 date "2009-08-01" @default.
- W2158800145 modified "2023-10-18" @default.
- W2158800145 title "The Death Receptor CD95 Activates Adult Neural Stem Cells for Working Memory Formation and Brain Repair" @default.
- W2158800145 cites W1523783037 @default.
- W2158800145 cites W1533245686 @default.
- W2158800145 cites W1581458838 @default.
- W2158800145 cites W1642763135 @default.
- W2158800145 cites W1925295143 @default.
- W2158800145 cites W1926043920 @default.
- W2158800145 cites W1959902108 @default.
- W2158800145 cites W1966010049 @default.
- W2158800145 cites W1978900577 @default.
- W2158800145 cites W1981404696 @default.
- W2158800145 cites W1983706324 @default.
- W2158800145 cites W1983955843 @default.
- W2158800145 cites W1985226621 @default.
- W2158800145 cites W1994416984 @default.
- W2158800145 cites W2001675158 @default.
- W2158800145 cites W2010053974 @default.
- W2158800145 cites W2015670274 @default.
- W2158800145 cites W2021931341 @default.
- W2158800145 cites W2025201985 @default.
- W2158800145 cites W2025604203 @default.
- W2158800145 cites W2028948697 @default.
- W2158800145 cites W2029593537 @default.
- W2158800145 cites W2043820074 @default.
- W2158800145 cites W2057608998 @default.
- W2158800145 cites W2059277649 @default.
- W2158800145 cites W2064836594 @default.
- W2158800145 cites W2075317738 @default.
- W2158800145 cites W2077627257 @default.
- W2158800145 cites W2078003702 @default.
- W2158800145 cites W2084521437 @default.
- W2158800145 cites W2093913291 @default.
- W2158800145 cites W2099923841 @default.
- W2158800145 cites W2105619265 @default.
- W2158800145 cites W2119928565 @default.
- W2158800145 cites W2132346729 @default.
- W2158800145 cites W2142360671 @default.
- W2158800145 cites W2143372016 @default.
- W2158800145 cites W2146032033 @default.
- W2158800145 cites W2147122201 @default.
- W2158800145 cites W2163382569 @default.
- W2158800145 cites W2164316007 @default.
- W2158800145 cites W2166050852 @default.
- W2158800145 cites W2167585898 @default.
- W2158800145 cites W2167626393 @default.
- W2158800145 cites W2168272960 @default.
- W2158800145 doi "https://doi.org/10.1016/j.stem.2009.05.004" @default.
- W2158800145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19664992" @default.
- W2158800145 hasPublicationYear "2009" @default.
- W2158800145 type Work @default.
- W2158800145 sameAs 2158800145 @default.
- W2158800145 citedByCount "115" @default.
- W2158800145 countsByYear W21588001452012 @default.
- W2158800145 countsByYear W21588001452013 @default.
- W2158800145 countsByYear W21588001452014 @default.
- W2158800145 countsByYear W21588001452015 @default.
- W2158800145 countsByYear W21588001452016 @default.
- W2158800145 countsByYear W21588001452017 @default.
- W2158800145 countsByYear W21588001452018 @default.
- W2158800145 countsByYear W21588001452019 @default.
- W2158800145 countsByYear W21588001452020 @default.
- W2158800145 countsByYear W21588001452021 @default.
- W2158800145 countsByYear W21588001452022 @default.
- W2158800145 countsByYear W21588001452023 @default.
- W2158800145 crossrefType "journal-article" @default.
- W2158800145 hasAuthorship W2158800145A5003387515 @default.
- W2158800145 hasAuthorship W2158800145A5007401051 @default.
- W2158800145 hasAuthorship W2158800145A5009783365 @default.
- W2158800145 hasAuthorship W2158800145A5013217770 @default.
- W2158800145 hasAuthorship W2158800145A5029501668 @default.
- W2158800145 hasAuthorship W2158800145A5033642963 @default.
- W2158800145 hasAuthorship W2158800145A5034870531 @default.
- W2158800145 hasAuthorship W2158800145A5039985608 @default.