FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158805605> ?p ?o ?g. }

• W2158805605 endingPage "1344" @default.
• W2158805605 startingPage "1341" @default.
• W2158805605 abstract "The dystonias comprise a heterogeneous group of hyperkinetic movement disorders characterized by involuntary muscle contractions that manifest as twisting, repetitive movements and abnormal postures. They are often misdiagnosed or unrecognized (Muller, 2009). These neurological syndromes are mainly of genetic origin and usually are not associated with gross neuropathological changes. Neurophysiological studies, imaging data and pathological findings support the hypothesis that multiple striatal, cortical, dopaminergic and cholinergic dysfunctions cause the motor alterations in the various forms of dystonias (Phukan et al. , 2011).Among the various primary dystonias, a form of adult-onset X-linked dystonia-parkinsonism (MIM314250), also known as DYT3 dystonia or ‘Lubag’ disease, has been described. It was reported for the first time in Filipino males from Panay Island. X-linked dystonia-parkinsonism appears predominantly as torsion dystonia, later either combined or replaced with parkinsonism. In females it has been reported in a milder clinical form with minor motor symptoms represented by parkinsonism and cervical dystonia and showing either slow or no clinical progression (Lee et al. , 2011).X-linked dystonia-parkinsonism is associated with sequence changes within the TAF1/DYT3 multiple transcript system. It has been postulated that this system might be linked with dopaminergic transmission, potentially explaining the parkinsonism observed in most patients in the late stages of the disease (Herzfeld et al. , 2013).Some clinical observations seem to correlate the pathophysiology of X-linked dystonia-parkinsonism with the dopaminergic basal ganglia circuit dysfunction that characterizes Parkinson’s disease. Hyposmia, a pre-motor symptom frequently reported in patients with Parkinson’s disease has also been demonstrated to occur in X-linked dystonia-parkinsonism (Evidente et al. , 2004). Moreover, bilateral pallidal stimulation, a therapeutic approach successfully utilized in Parkinson’s disease, also ameliorates symptoms in patients with X-linked dystonia-parkinsonism (Fig. 1) (Evidente et al. , 2007). Other findings argue against this view. Indeed, although a selective reduction …" @default.
• W2158805605 created "2016-06-24" @default.
• W2158805605 creator A5050850872 @default.
• W2158805605 creator A5088823694 @default.
• W2158805605 date "2013-04-18" @default.
• W2158805605 modified "2023-10-17" @default.
• W2158805605 title "A pathophysiological link between dystonia, striatal interneurons and neuropeptide Y" @default.
• W2158805605 cites W1980462990 @default.
• W2158805605 cites W1989387017 @default.
• W2158805605 cites W2008702925 @default.
• W2158805605 cites W2029999018 @default.
• W2158805605 cites W2033553670 @default.
• W2158805605 cites W2049966877 @default.
• W2158805605 cites W2075511942 @default.
• W2158805605 cites W2076274901 @default.
• W2158805605 cites W2106556204 @default.
• W2158805605 cites W2119992788 @default.
• W2158805605 cites W2124659766 @default.
• W2158805605 cites W2132182674 @default.
• W2158805605 cites W2153724434 @default.
• W2158805605 cites W2154290883 @default.
• W2158805605 doi "https://doi.org/10.1093/brain/awt096" @default.
• W2158805605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23599388" @default.
• W2158805605 hasPublicationYear "2013" @default.
• W2158805605 type Work @default.
• W2158805605 sameAs 2158805605 @default.
• W2158805605 citedByCount "3" @default.
• W2158805605 countsByYear W21588056052015 @default.
• W2158805605 countsByYear W21588056052021 @default.
• W2158805605 countsByYear W21588056052023 @default.
• W2158805605 crossrefType "journal-article" @default.
• W2158805605 hasAuthorship W2158805605A5050850872 @default.
• W2158805605 hasAuthorship W2158805605A5088823694 @default.
• W2158805605 hasBestOaLocation W21588056051 @default.
• W2158805605 hasConcept C10162356 @default.
• W2158805605 hasConcept C118303440 @default.
• W2158805605 hasConcept C126322002 @default.
• W2158805605 hasConcept C15744967 @default.
• W2158805605 hasConcept C169760540 @default.
• W2158805605 hasConcept C170493617 @default.
• W2158805605 hasConcept C2778187257 @default.
• W2158805605 hasConcept C2778542668 @default.
• W2158805605 hasConcept C2778559928 @default.
• W2158805605 hasConcept C2779134260 @default.
• W2158805605 hasConcept C2779734285 @default.
• W2158805605 hasConcept C529278444 @default.
• W2158805605 hasConcept C71924100 @default.
• W2158805605 hasConcept C93984277 @default.
• W2158805605 hasConceptScore W2158805605C10162356 @default.
• W2158805605 hasConceptScore W2158805605C118303440 @default.
• W2158805605 hasConceptScore W2158805605C126322002 @default.
• W2158805605 hasConceptScore W2158805605C15744967 @default.
• W2158805605 hasConceptScore W2158805605C169760540 @default.
• W2158805605 hasConceptScore W2158805605C170493617 @default.
• W2158805605 hasConceptScore W2158805605C2778187257 @default.
• W2158805605 hasConceptScore W2158805605C2778542668 @default.
• W2158805605 hasConceptScore W2158805605C2778559928 @default.
• W2158805605 hasConceptScore W2158805605C2779134260 @default.
• W2158805605 hasConceptScore W2158805605C2779734285 @default.
• W2158805605 hasConceptScore W2158805605C529278444 @default.
• W2158805605 hasConceptScore W2158805605C71924100 @default.
• W2158805605 hasConceptScore W2158805605C93984277 @default.
• W2158805605 hasIssue "5" @default.
• W2158805605 hasLocation W21588056051 @default.
• W2158805605 hasLocation W21588056052 @default.
• W2158805605 hasOpenAccess W2158805605 @default.
• W2158805605 hasPrimaryLocation W21588056051 @default.
• W2158805605 hasRelatedWork W2030876716 @default.
• W2158805605 hasRelatedWork W2115116088 @default.
• W2158805605 hasRelatedWork W2295433647 @default.
• W2158805605 hasRelatedWork W2323892133 @default.
• W2158805605 hasRelatedWork W2328673296 @default.
• W2158805605 hasRelatedWork W2398062905 @default.
• W2158805605 hasRelatedWork W2509202224 @default.
• W2158805605 hasRelatedWork W2891209640 @default.
• W2158805605 hasRelatedWork W3196626753 @default.
• W2158805605 hasRelatedWork W4292940438 @default.
• W2158805605 hasVolume "136" @default.
• W2158805605 isParatext "false" @default.
• W2158805605 isRetracted "false" @default.
• W2158805605 magId "2158805605" @default.
• W2158805605 workType "article" @default.