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- W2158812794 abstract "Background and Purpose To test a hypothesis that: (i) duodenal pH and osmolarity are individually controlled at constant set points by negative feedback control centred in the enteric nervous system ( ENS ); (ii) the purinergic P2Y 1 receptor subtype is expressed by non‐cholinergic secretomotor/vasodilator neurons, which represent the final common excitatory pathway from the ENS to the bicarbonate secretory glands. Experimental Approach Ussing chamber and pH ‐stat methods investigated involvement of the P2Y 1 receptor in neurogenic stimulation of mucosal bicarbonate ( HCO 3 − ) secretion in guinea pig duodenum. Key Results ATP increased HCO 3 − secretion with an EC 50 of 160 nM . MRS2179 , a selective P2Y 1 purinergic receptor antagonist, suppressed ATP ‐evoked HCO 3 − secretion by 47% and C l − secretion by 63%. Enteric neuronal blockade by tetrodotoxin or exposure to a selective vasoactive intestinal peptide ( VIP , VPAC 1 ) receptor antagonist suppressed ATP ‐evoked HCO 3 − secretion by 61 and 41%, respectively, and C l‐ by 97 and 70% respectively. Pretreatment with the muscarinic antagonist, scopolamine did not alter ATP ‐evoked HCO3 − or C l − secretion. Conclusion and Implications Whereas acid directly stimulates the mucosa to release ATP and stimulate HCO 3 − secretion in a cytoprotective manner, neurogenically evoked HCO 3 − secretion accounts for feedback control of optimal luminal pH for digestion. ATP stimulates duodenal HCO 3 − secretion through an excitatory action at purinergic P2Y 1 receptors on neurons in the submucosal division of the ENS . Stimulation of the VIP ergic non‐cholinergic secretomotor/vasodilator neurons, which are one of three classes of secretomotor neurons, accounts for most, if not all, of the neurogenic secretory response evoked by ATP ." @default.
- W2158812794 created "2016-06-24" @default.
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- W2158812794 date "2013-01-24" @default.
- W2158812794 modified "2023-10-17" @default.
- W2158812794 title "Neurogenic mucosal bicarbonate secretion in guinea pig duodenum" @default.
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- W2158812794 doi "https://doi.org/10.1111/j.1476-5381.2012.02218.x" @default.
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