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• W2158825995 abstract "In this work, we analyse the blistered function in wing vein development by studying genetic mosaics of mutant cells, genetic interactions with other genes affecting vein development and blistered expression in several mutant backgrounds. blistered encodes for a nuclear protein homologous to the mammalian Serum Response Factor and is expressed in presumptive intervein cells of third larval instar and pupal wing discs. Clones of blistered mutant cells proliferate normally but tend to grow along veins and always differentiate as vein tissue. These observations indicate that vein-determined wing cells show a particular behaviour that is responsible for their allocation to vein regions. We observe strong genetic interactions between blistered, veinlet and genes of the Ras signaling cascade. During disc proliferation, blistered expression is under the control of the Ras signal transduction pathway, but its expression is independent of veinlet. During the pupal period, blistered and veinlet expression become interdependent and mutually exclusive. These results link the activity of the Ras pathway to the process of early determination of intervein cells, by the transcriptional control of the blistered nuclear factor." @default.
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• W2158825995 date "1998-05-15" @default.
• W2158825995 modified "2023-09-27" @default.
• W2158825995 title "Genetic interactions and cell behaviour in <i>blistered</i> mutants during proliferation and differentiation of the <i>Drosophila</i> wing" @default.
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• W2158825995 doi "https://doi.org/10.1242/dev.125.10.1823" @default.
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