Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158834590> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2158834590 endingPage "12" @default.
- W2158834590 startingPage "8" @default.
- W2158834590 abstract "Inherited long QT syndrome (LQTS) may present with syncope, seizures, and/or sudden death as a result of ventricular tachyarrhythmias. Identification of family members who are at risk because they harbor the genetic substrate for LQTS is critical. Presently, such identification relies on the 12-lead electrocardiogram (ECG). The purpose of this study was to evaluate the efficacy of the automated ECG as a screening tool for LQTS.Molecular testing of a proband and 22 additional family members for the KVLQT1 mutation and symptomatic status facilitated the classification of each family member into the following patient groups: noncarriers (13), asymptomatic carriers (5), and symptomatic carriers (5). Each individual had a standard 12-lead ECG from which the computer and manual (lead II) corrected QT interval were determined. In addition, we determined the accuracy of the computer ECG diagnostic interpretation for each patient group.With the use of a corrected QT interval of >/=460 ms as a diagnostic cutoff, the positive and negative predictive values for identifying at-risk individuals were 100%. Despite this, the computer-generated ECG diagnostic interpretation erroneously classified 6 of 23 family members. Moreover, half of the family members, proved to have the ion channel defect, received the diagnostic interpretation normal ECG.Reliance on the computer-generated ECG diagnostic interpretation alone will fail to identify many at-risk family members. It is suggested that all first-degree relatives of an identified LQTS proband have a 12-lead ECG that is reviewed independently by a physician who is familiar with LQTS in an effort to improve screening for this potentially lethal syndrome.electrocardiogram, long QT syndrome, QT interval, sudden death." @default.
- W2158834590 created "2016-06-24" @default.
- W2158834590 creator A5038871944 @default.
- W2158834590 creator A5055125250 @default.
- W2158834590 creator A5089773921 @default.
- W2158834590 date "2001-07-01" @default.
- W2158834590 modified "2023-09-27" @default.
- W2158834590 title "Diagnostic Accuracy of Screening Electrocardiograms in Long QT Syndrome I" @default.
- W2158834590 cites W1750868647 @default.
- W2158834590 cites W1989906944 @default.
- W2158834590 cites W1992831619 @default.
- W2158834590 cites W2000733439 @default.
- W2158834590 cites W2008125074 @default.
- W2158834590 cites W2010302358 @default.
- W2158834590 cites W2014862626 @default.
- W2158834590 cites W2017086716 @default.
- W2158834590 cites W2019872654 @default.
- W2158834590 cites W2023890734 @default.
- W2158834590 cites W2030226418 @default.
- W2158834590 cites W2035106953 @default.
- W2158834590 cites W2047152727 @default.
- W2158834590 cites W2052593384 @default.
- W2158834590 cites W2063242638 @default.
- W2158834590 cites W2073582510 @default.
- W2158834590 cites W2074603053 @default.
- W2158834590 cites W2085199612 @default.
- W2158834590 cites W2159585968 @default.
- W2158834590 cites W2334363451 @default.
- W2158834590 cites W2767534813 @default.
- W2158834590 doi "https://doi.org/10.1542/peds.108.1.8" @default.
- W2158834590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11986469" @default.
- W2158834590 hasPublicationYear "2001" @default.
- W2158834590 type Work @default.
- W2158834590 sameAs 2158834590 @default.
- W2158834590 citedByCount "50" @default.
- W2158834590 countsByYear W21588345902012 @default.
- W2158834590 countsByYear W21588345902013 @default.
- W2158834590 countsByYear W21588345902014 @default.
- W2158834590 countsByYear W21588345902015 @default.
- W2158834590 countsByYear W21588345902016 @default.
- W2158834590 countsByYear W21588345902017 @default.
- W2158834590 countsByYear W21588345902018 @default.
- W2158834590 countsByYear W21588345902019 @default.
- W2158834590 countsByYear W21588345902020 @default.
- W2158834590 countsByYear W21588345902021 @default.
- W2158834590 crossrefType "journal-article" @default.
- W2158834590 hasAuthorship W2158834590A5038871944 @default.
- W2158834590 hasAuthorship W2158834590A5055125250 @default.
- W2158834590 hasAuthorship W2158834590A5089773921 @default.
- W2158834590 hasConcept C104317684 @default.
- W2158834590 hasConcept C118441451 @default.
- W2158834590 hasConcept C126322002 @default.
- W2158834590 hasConcept C164705383 @default.
- W2158834590 hasConcept C188997412 @default.
- W2158834590 hasConcept C2777910003 @default.
- W2158834590 hasConcept C2779703243 @default.
- W2158834590 hasConcept C2993353509 @default.
- W2158834590 hasConcept C501734568 @default.
- W2158834590 hasConcept C54355233 @default.
- W2158834590 hasConcept C71924100 @default.
- W2158834590 hasConcept C86803240 @default.
- W2158834590 hasConceptScore W2158834590C104317684 @default.
- W2158834590 hasConceptScore W2158834590C118441451 @default.
- W2158834590 hasConceptScore W2158834590C126322002 @default.
- W2158834590 hasConceptScore W2158834590C164705383 @default.
- W2158834590 hasConceptScore W2158834590C188997412 @default.
- W2158834590 hasConceptScore W2158834590C2777910003 @default.
- W2158834590 hasConceptScore W2158834590C2779703243 @default.
- W2158834590 hasConceptScore W2158834590C2993353509 @default.
- W2158834590 hasConceptScore W2158834590C501734568 @default.
- W2158834590 hasConceptScore W2158834590C54355233 @default.
- W2158834590 hasConceptScore W2158834590C71924100 @default.
- W2158834590 hasConceptScore W2158834590C86803240 @default.
- W2158834590 hasIssue "1" @default.
- W2158834590 hasLocation W21588345901 @default.
- W2158834590 hasLocation W21588345902 @default.
- W2158834590 hasOpenAccess W2158834590 @default.
- W2158834590 hasPrimaryLocation W21588345901 @default.
- W2158834590 hasRelatedWork W123027860 @default.
- W2158834590 hasRelatedWork W130567547 @default.
- W2158834590 hasRelatedWork W1999131383 @default.
- W2158834590 hasRelatedWork W2060304509 @default.
- W2158834590 hasRelatedWork W2068713060 @default.
- W2158834590 hasRelatedWork W2097453160 @default.
- W2158834590 hasRelatedWork W2320629847 @default.
- W2158834590 hasRelatedWork W2398840239 @default.
- W2158834590 hasRelatedWork W2772260060 @default.
- W2158834590 hasRelatedWork W4361243010 @default.
- W2158834590 hasVolume "108" @default.
- W2158834590 isParatext "false" @default.
- W2158834590 isRetracted "false" @default.
- W2158834590 magId "2158834590" @default.
- W2158834590 workType "article" @default.