Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158864582> ?p ?o ?g. }
- W2158864582 endingPage "759" @default.
- W2158864582 startingPage "754" @default.
- W2158864582 abstract "Recent research progress indicates a close link between ghrelin, a natural ligand of GH secretagogues receptor (GHS-R), and both the metabolic balance and body composition. To clarify the involvement of ghrelin and GHS-R in the process of adipogenesis, we measured the expression of GHS-R and peroxisome proliferator-activated receptor gamma 2 (PPAR-gamma 2) mRNA in rat adipocytes using semiquantitative RT-PCR methods. The levels of GHS-R mRNA increased by up to 4-fold in adipose tissue from epididymal and parametrial regions as the rat aged from 4-20 wk and were significantly elevated during the differentiation of preadipocytes in vitro. Ghrelin (10(-8) M for 10 d) stimulated the activity of glycerol-3-phosphate dehydrogenase and the differentiation of rat preadipocytes in vitro. Ghrelin treatment also significantly increased the levels of PPAR-gamma 2 mRNA in primary cultured rat differentiated adipocytes. In addition, isoproterenol (10(-8) M, 40 min)-stimulated lipolysis was significantly reduced by simultaneous ghrelin treatment in a dose-dependent manner in vitro. In conclusion, the expression of GHS-R in rat adipocytes increases with the age and during adipogenesis. Ghrelin in vitro stimulates the differentiation of preadipocytes and antagonizes lipolysis. Ghrelin may therefore play an important role in the process of adipogenesis in rats." @default.
- W2158864582 created "2016-06-24" @default.
- W2158864582 creator A5011441043 @default.
- W2158864582 creator A5012361101 @default.
- W2158864582 creator A5026456737 @default.
- W2158864582 creator A5040672818 @default.
- W2158864582 creator A5062232273 @default.
- W2158864582 creator A5063253432 @default.
- W2158864582 creator A5065254374 @default.
- W2158864582 creator A5068354355 @default.
- W2158864582 creator A5080822459 @default.
- W2158864582 date "2003-03-01" @default.
- W2158864582 modified "2023-10-13" @default.
- W2158864582 title "The Role of Ghrelin and Growth Hormone Secretagogues Receptor on Rat Adipogenesis" @default.
- W2158864582 cites W1486029121 @default.
- W2158864582 cites W1547232376 @default.
- W2158864582 cites W1574770390 @default.
- W2158864582 cites W1616806865 @default.
- W2158864582 cites W1637971961 @default.
- W2158864582 cites W1815087127 @default.
- W2158864582 cites W1901716085 @default.
- W2158864582 cites W1966752541 @default.
- W2158864582 cites W1969842165 @default.
- W2158864582 cites W1975927677 @default.
- W2158864582 cites W2002519246 @default.
- W2158864582 cites W2010371973 @default.
- W2158864582 cites W2029383686 @default.
- W2158864582 cites W2029731502 @default.
- W2158864582 cites W2034697008 @default.
- W2158864582 cites W2040993124 @default.
- W2158864582 cites W2059198255 @default.
- W2158864582 cites W2069430618 @default.
- W2158864582 cites W2074601711 @default.
- W2158864582 cites W2085218910 @default.
- W2158864582 cites W2093706331 @default.
- W2158864582 cites W2101433806 @default.
- W2158864582 cites W2103817177 @default.
- W2158864582 cites W2111536564 @default.
- W2158864582 cites W2112202133 @default.
- W2158864582 cites W2113628166 @default.
- W2158864582 cites W2121294749 @default.
- W2158864582 cites W2125344994 @default.
- W2158864582 cites W2126898107 @default.
- W2158864582 cites W2128635872 @default.
- W2158864582 cites W2129700656 @default.
- W2158864582 cites W2163865122 @default.
- W2158864582 cites W2164015929 @default.
- W2158864582 cites W2166671643 @default.
- W2158864582 cites W2172272645 @default.
- W2158864582 cites W2190290207 @default.
- W2158864582 cites W2403451388 @default.
- W2158864582 cites W30218241 @default.
- W2158864582 doi "https://doi.org/10.1210/en.2002-220783" @default.
- W2158864582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12586750" @default.
- W2158864582 hasPublicationYear "2003" @default.
- W2158864582 type Work @default.
- W2158864582 sameAs 2158864582 @default.
- W2158864582 citedByCount "226" @default.
- W2158864582 countsByYear W21588645822012 @default.
- W2158864582 countsByYear W21588645822013 @default.
- W2158864582 countsByYear W21588645822014 @default.
- W2158864582 countsByYear W21588645822015 @default.
- W2158864582 countsByYear W21588645822016 @default.
- W2158864582 countsByYear W21588645822017 @default.
- W2158864582 countsByYear W21588645822018 @default.
- W2158864582 countsByYear W21588645822019 @default.
- W2158864582 countsByYear W21588645822020 @default.
- W2158864582 countsByYear W21588645822021 @default.
- W2158864582 countsByYear W21588645822022 @default.
- W2158864582 countsByYear W21588645822023 @default.
- W2158864582 crossrefType "journal-article" @default.
- W2158864582 hasAuthorship W2158864582A5011441043 @default.
- W2158864582 hasAuthorship W2158864582A5012361101 @default.
- W2158864582 hasAuthorship W2158864582A5026456737 @default.
- W2158864582 hasAuthorship W2158864582A5040672818 @default.
- W2158864582 hasAuthorship W2158864582A5062232273 @default.
- W2158864582 hasAuthorship W2158864582A5063253432 @default.
- W2158864582 hasAuthorship W2158864582A5065254374 @default.
- W2158864582 hasAuthorship W2158864582A5068354355 @default.
- W2158864582 hasAuthorship W2158864582A5080822459 @default.
- W2158864582 hasConcept C122927707 @default.
- W2158864582 hasConcept C126322002 @default.
- W2158864582 hasConcept C134018914 @default.
- W2158864582 hasConcept C140985366 @default.
- W2158864582 hasConcept C170493617 @default.
- W2158864582 hasConcept C171089720 @default.
- W2158864582 hasConcept C185592680 @default.
- W2158864582 hasConcept C2779357093 @default.
- W2158864582 hasConcept C71315377 @default.
- W2158864582 hasConcept C71924100 @default.
- W2158864582 hasConcept C86803240 @default.
- W2158864582 hasConceptScore W2158864582C122927707 @default.
- W2158864582 hasConceptScore W2158864582C126322002 @default.
- W2158864582 hasConceptScore W2158864582C134018914 @default.
- W2158864582 hasConceptScore W2158864582C140985366 @default.
- W2158864582 hasConceptScore W2158864582C170493617 @default.
- W2158864582 hasConceptScore W2158864582C171089720 @default.
- W2158864582 hasConceptScore W2158864582C185592680 @default.