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- W2158914568 abstract "The degradation of procainamide in highly acidic aqueous media has been shown to occur virtually entirely through hydrolytic cleavage of the amide function. The reaction is first order with respect to procainamide and directly dependent upon hydrogen ion concentration. The temperature dependency of the hydrolytic reaction has been determined and the catalytic constants evaluated. Although the activation energy is apparently much too low in view of the expected effect of the p -ammonium substituent on the acid moiety, the apparent difficulty is resolved by showing that, under the conditions employed, procainamide may respond like an ester rather than an amide." @default.
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- W2158914568 date "1957-01-01" @default.
- W2158914568 modified "2023-09-26" @default.
- W2158914568 title "A Kinetic Study of the Acid-Catalyzed Hydrolysis of Procainamide * *Rutgers University College of Pharmacy, Newark 4, New Jersey" @default.
- W2158914568 cites W1563124950 @default.
- W2158914568 doi "https://doi.org/10.1002/jps.3030460108" @default.
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