FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158914897> ?p ?o ?g. }

• W2158914897 endingPage "362" @default.
• W2158914897 startingPage "355" @default.
• W2158914897 abstract "Human chromosome 7 open reading frame 24 (C7orf24)/γ-glutamyl cyclotransferase has been suggested to be a potential diagnostic marker for several cancers, including carcinomas in the bladder urothelium, breast and endometrial epithelium. We here investigated the epigenetic regulation of the human C7orf24 promoter in normal diploid ARPE-19 and IMR-90 cells and in the MCF-7 and HeLa cancer cell lines to understand the transcriptional basis for the malignant-associated high expression of C7orf24. Chromatin immunoprecipitation analysis revealed that histone modifications associated with active chromatin were enriched in the proximal region but not in the distal region of the C7orf24 promoter in HeLa and MCF-7 cells. In contrast, elevated levels of histone modifications leading to transcriptional repression and accumulation of heterochromatin proteins in the C7orf24 promoter were observed in the ARPE-19 and IMR-90 cells, compared to the levels in HeLa and MCF-7 cancer cells. In parallel, the CpG island of the C7orf24 promoter was methylated to a greater extent in the normal cells than in the cancer cells. These results suggest that the transcriptional silencing of the C7orf24 gene in the non-malignant cells is elicited through heterochromatin formation in its promoter region; aberrant expression of C7orf24 associated with malignant alterations results from changes in chromatin dynamics." @default.
• W2158914897 created "2016-06-24" @default.
• W2158914897 creator A5039626151 @default.
• W2158914897 creator A5043652685 @default.
• W2158914897 creator A5080896380 @default.
• W2158914897 creator A5091136428 @default.
• W2158914897 date "2013-07-12" @default.
• W2158914897 modified "2023-09-27" @default.
• W2158914897 title "Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells" @default.
• W2158914897 cites W1503024026 @default.
• W2158914897 cites W1752008811 @default.
• W2158914897 cites W1965262464 @default.
• W2158914897 cites W1968242645 @default.
• W2158914897 cites W1982149099 @default.
• W2158914897 cites W1995019620 @default.
• W2158914897 cites W2010611789 @default.
• W2158914897 cites W2017694656 @default.
• W2158914897 cites W2028239334 @default.
• W2158914897 cites W2048529245 @default.
• W2158914897 cites W2050601407 @default.
• W2158914897 cites W2053192881 @default.
• W2158914897 cites W2057733993 @default.
• W2158914897 cites W2058750330 @default.
• W2158914897 cites W2060608189 @default.
• W2158914897 cites W2065782017 @default.
• W2158914897 cites W2068394634 @default.
• W2158914897 cites W2079254150 @default.
• W2158914897 cites W2084659150 @default.
• W2158914897 cites W2096330673 @default.
• W2158914897 cites W2107884608 @default.
• W2158914897 cites W2144366450 @default.
• W2158914897 cites W2144806790 @default.
• W2158914897 cites W2152497434 @default.
• W2158914897 cites W2163454545 @default.
• W2158914897 cites W2401592928 @default.
• W2158914897 doi "https://doi.org/10.1093/jb/mvt063" @default.
• W2158914897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23853312" @default.
• W2158914897 hasPublicationYear "2013" @default.
• W2158914897 type Work @default.
• W2158914897 sameAs 2158914897 @default.
• W2158914897 citedByCount "6" @default.
• W2158914897 countsByYear W21589148972015 @default.
• W2158914897 countsByYear W21589148972016 @default.
• W2158914897 countsByYear W21589148972018 @default.
• W2158914897 countsByYear W21589148972019 @default.
• W2158914897 crossrefType "journal-article" @default.
• W2158914897 hasAuthorship W2158914897A5039626151 @default.
• W2158914897 hasAuthorship W2158914897A5043652685 @default.
• W2158914897 hasAuthorship W2158914897A5080896380 @default.
• W2158914897 hasAuthorship W2158914897A5091136428 @default.
• W2158914897 hasConcept C101762097 @default.
• W2158914897 hasConcept C103435993 @default.
• W2158914897 hasConcept C104317684 @default.
• W2158914897 hasConcept C119056186 @default.
• W2158914897 hasConcept C121608353 @default.
• W2158914897 hasConcept C134320426 @default.
• W2158914897 hasConcept C150194340 @default.
• W2158914897 hasConcept C153911025 @default.
• W2158914897 hasConcept C165864922 @default.
• W2158914897 hasConcept C190727270 @default.
• W2158914897 hasConcept C2776745794 @default.
• W2158914897 hasConcept C2777366897 @default.
• W2158914897 hasConcept C41091548 @default.
• W2158914897 hasConcept C502942594 @default.
• W2158914897 hasConcept C54355233 @default.
• W2158914897 hasConcept C64927066 @default.
• W2158914897 hasConcept C81885089 @default.
• W2158914897 hasConcept C83640560 @default.
• W2158914897 hasConcept C86803240 @default.
• W2158914897 hasConcept C96232424 @default.
• W2158914897 hasConceptScore W2158914897C101762097 @default.
• W2158914897 hasConceptScore W2158914897C103435993 @default.
• W2158914897 hasConceptScore W2158914897C104317684 @default.
• W2158914897 hasConceptScore W2158914897C119056186 @default.
• W2158914897 hasConceptScore W2158914897C121608353 @default.
• W2158914897 hasConceptScore W2158914897C134320426 @default.
• W2158914897 hasConceptScore W2158914897C150194340 @default.
• W2158914897 hasConceptScore W2158914897C153911025 @default.
• W2158914897 hasConceptScore W2158914897C165864922 @default.
• W2158914897 hasConceptScore W2158914897C190727270 @default.
• W2158914897 hasConceptScore W2158914897C2776745794 @default.
• W2158914897 hasConceptScore W2158914897C2777366897 @default.
• W2158914897 hasConceptScore W2158914897C41091548 @default.
• W2158914897 hasConceptScore W2158914897C502942594 @default.
• W2158914897 hasConceptScore W2158914897C54355233 @default.
• W2158914897 hasConceptScore W2158914897C64927066 @default.
• W2158914897 hasConceptScore W2158914897C81885089 @default.
• W2158914897 hasConceptScore W2158914897C83640560 @default.
• W2158914897 hasConceptScore W2158914897C86803240 @default.
• W2158914897 hasConceptScore W2158914897C96232424 @default.
• W2158914897 hasIssue "4" @default.
• W2158914897 hasLocation W21589148971 @default.
• W2158914897 hasLocation W21589148972 @default.
• W2158914897 hasOpenAccess W2158914897 @default.
• W2158914897 hasPrimaryLocation W21589148971 @default.
• W2158914897 hasRelatedWork W1553671245 @default.
• W2158914897 hasRelatedWork W2000722028 @default.
• W2158914897 hasRelatedWork W2086275191 @default.

• next