Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158968421> ?p ?o ?g. }
- W2158968421 endingPage "5548" @default.
- W2158968421 startingPage "5541" @default.
- W2158968421 abstract "Reduced thymopoiesis and continuous mobilization of naive T cells into the effector-memory pool can lead to severe alterations of the naive T cell compartment. However, maintenance of the naive T cell population is essential to mount effective immune responses. Evidence of homeostatic regulation of naive T cells is currently debated in animal models. In humans, the situation remains unresolved, in particular with advanced age. In this study, we analyzed the CD4(+) and CD8(+) naive T cell compartments from elderly, young adults thymectomized during early childhood, and HIV-1-infected patients, which are characterized by T lymphocytopenia. We show a direct association between increased turnover and decreased frequency of naive T cells. Moreover, the IL-7-induced pathway was fully functional in naive T cells from elderly and young adults thymectomized during early childhood, who are characterized by elevated IL-7 plasma levels. Our findings support the establishment of homeostatic regulation of naive T cell proliferation in humans. This regulation is particularly active in lymphopenic hosts, such as elderly and thymectomized patients." @default.
- W2158968421 created "2016-06-24" @default.
- W2158968421 creator A5000584378 @default.
- W2158968421 creator A5017386021 @default.
- W2158968421 creator A5044666153 @default.
- W2158968421 creator A5053023344 @default.
- W2158968421 creator A5053965677 @default.
- W2158968421 creator A5057491109 @default.
- W2158968421 creator A5061193503 @default.
- W2158968421 creator A5064572837 @default.
- W2158968421 creator A5072720584 @default.
- W2158968421 date "2012-11-07" @default.
- W2158968421 modified "2023-10-15" @default.
- W2158968421 title "Lymphopenia-Driven Homeostatic Regulation of Naive T Cells in Elderly and Thymectomized Young Adults" @default.
- W2158968421 cites W1480768075 @default.
- W2158968421 cites W1508824021 @default.
- W2158968421 cites W1544307647 @default.
- W2158968421 cites W1601504908 @default.
- W2158968421 cites W1652988747 @default.
- W2158968421 cites W1893260165 @default.
- W2158968421 cites W1926141441 @default.
- W2158968421 cites W1965845165 @default.
- W2158968421 cites W1970790405 @default.
- W2158968421 cites W1983818591 @default.
- W2158968421 cites W1985266927 @default.
- W2158968421 cites W1986655623 @default.
- W2158968421 cites W1987654565 @default.
- W2158968421 cites W1991601117 @default.
- W2158968421 cites W1992031335 @default.
- W2158968421 cites W1994844769 @default.
- W2158968421 cites W1995716646 @default.
- W2158968421 cites W1996743291 @default.
- W2158968421 cites W2000525428 @default.
- W2158968421 cites W2003708788 @default.
- W2158968421 cites W2026000112 @default.
- W2158968421 cites W2028275698 @default.
- W2158968421 cites W2028402895 @default.
- W2158968421 cites W2033179357 @default.
- W2158968421 cites W2046247568 @default.
- W2158968421 cites W2046906378 @default.
- W2158968421 cites W2048923715 @default.
- W2158968421 cites W2049115432 @default.
- W2158968421 cites W2055532057 @default.
- W2158968421 cites W2059239713 @default.
- W2158968421 cites W2066429820 @default.
- W2158968421 cites W2066587571 @default.
- W2158968421 cites W2069043306 @default.
- W2158968421 cites W2073129195 @default.
- W2158968421 cites W2080181628 @default.
- W2158968421 cites W2090958278 @default.
- W2158968421 cites W2091687755 @default.
- W2158968421 cites W2101341649 @default.
- W2158968421 cites W2104601608 @default.
- W2158968421 cites W2129457251 @default.
- W2158968421 cites W2140058614 @default.
- W2158968421 cites W2149851148 @default.
- W2158968421 cites W2153680933 @default.
- W2158968421 cites W2156449737 @default.
- W2158968421 cites W2158082223 @default.
- W2158968421 cites W2161961972 @default.
- W2158968421 cites W2165981943 @default.
- W2158968421 cites W2169779391 @default.
- W2158968421 cites W2172187744 @default.
- W2158968421 cites W2323147012 @default.
- W2158968421 cites W2334332481 @default.
- W2158968421 doi "https://doi.org/10.4049/jimmunol.1201235" @default.
- W2158968421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23136199" @default.
- W2158968421 hasPublicationYear "2012" @default.
- W2158968421 type Work @default.
- W2158968421 sameAs 2158968421 @default.
- W2158968421 citedByCount "73" @default.
- W2158968421 countsByYear W21589684212013 @default.
- W2158968421 countsByYear W21589684212014 @default.
- W2158968421 countsByYear W21589684212015 @default.
- W2158968421 countsByYear W21589684212016 @default.
- W2158968421 countsByYear W21589684212017 @default.
- W2158968421 countsByYear W21589684212018 @default.
- W2158968421 countsByYear W21589684212019 @default.
- W2158968421 countsByYear W21589684212020 @default.
- W2158968421 countsByYear W21589684212021 @default.
- W2158968421 countsByYear W21589684212022 @default.
- W2158968421 countsByYear W21589684212023 @default.
- W2158968421 crossrefType "journal-article" @default.
- W2158968421 hasAuthorship W2158968421A5000584378 @default.
- W2158968421 hasAuthorship W2158968421A5017386021 @default.
- W2158968421 hasAuthorship W2158968421A5044666153 @default.
- W2158968421 hasAuthorship W2158968421A5053023344 @default.
- W2158968421 hasAuthorship W2158968421A5053965677 @default.
- W2158968421 hasAuthorship W2158968421A5057491109 @default.
- W2158968421 hasAuthorship W2158968421A5061193503 @default.
- W2158968421 hasAuthorship W2158968421A5064572837 @default.
- W2158968421 hasAuthorship W2158968421A5072720584 @default.
- W2158968421 hasConcept C167672396 @default.
- W2158968421 hasConcept C19317047 @default.
- W2158968421 hasConcept C203014093 @default.
- W2158968421 hasConcept C2775982045 @default.
- W2158968421 hasConcept C2776090121 @default.
- W2158968421 hasConcept C2777761686 @default.