FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158979404> ?p ?o ?g. }

• W2158979404 endingPage "G122" @default.
• W2158979404 startingPage "G116" @default.
• W2158979404 abstract "Hepatocyte inducible nitric oxide synthese (iNOS) expression is a tightly controlled pathway that mediates hepatic inflammation and hepatocyte injury in a variety of disease states. We have shown that cyclic adenosine monophosphate (cAMP) regulates cytokine-induced hepatocyte iNOS expression through mechanisms that involve protein kinase B/Akt. We hypothesized that insulin, which activates Akt signaling in hepatocytes, as well as signaling through p38 and MAPK p42/p44, would regulate iNOS expression during inflammation. In primary rat hepatocytes, insulin inhibited cytokine-stimulated nitrite accumulation and iNOS expression in a dose-dependent manner. Inhibition of MAPK p42/p44 with PD98059 had no effect on iNOS activation, whereas SB203580 to block p38 reversed insulin's inhibitory effect. However, insulin did not increase p38 activation and inhibition of p38 signaling with a dominant negative p38 plasmid had no effect on cytokine- or insulin-mediated effects on iNOS. We found that SB203580 blocked insulin-induced Akt activation. Inhibition of Akt signaling with LY294002 or a dominant negative Akt plasmid increased cytokine-stimulated nitrite production and iNOS protein expression and blocked the inhibitory effects of insulin. NF-κB induces iNOS expression and can be regulated by Akt, but insulin had no effect on cytokine-mediated IκBα levels or NF-κB p65 translocation. Our data demonstrate that insulin inhibits cytokine-stimulated hepatocyte iNOS expression and does so through effects on Akt-mediated signaling." @default.
• W2158979404 created "2016-06-24" @default.
• W2158979404 creator A5001904860 @default.
• W2158979404 creator A5015745014 @default.
• W2158979404 creator A5076458634 @default.
• W2158979404 creator A5079186811 @default.
• W2158979404 date "2012-01-01" @default.
• W2158979404 modified "2023-09-27" @default.
• W2158979404 title "Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanism" @default.
• W2158979404 cites W1583767403 @default.
• W2158979404 cites W1735966469 @default.
• W2158979404 cites W1854481493 @default.
• W2158979404 cites W1969444463 @default.
• W2158979404 cites W1971727526 @default.
• W2158979404 cites W1972692051 @default.
• W2158979404 cites W1973459352 @default.
• W2158979404 cites W1977384350 @default.
• W2158979404 cites W1979171780 @default.
• W2158979404 cites W1980717583 @default.
• W2158979404 cites W1985118687 @default.
• W2158979404 cites W1999505705 @default.
• W2158979404 cites W2002064752 @default.
• W2158979404 cites W2003922276 @default.
• W2158979404 cites W2011588737 @default.
• W2158979404 cites W2022398608 @default.
• W2158979404 cites W2024136349 @default.
• W2158979404 cites W2028211096 @default.
• W2158979404 cites W2033015281 @default.
• W2158979404 cites W2038376941 @default.
• W2158979404 cites W2039155288 @default.
• W2158979404 cites W2040576088 @default.
• W2158979404 cites W2046822015 @default.
• W2158979404 cites W2055200953 @default.
• W2158979404 cites W2060284302 @default.
• W2158979404 cites W2063034138 @default.
• W2158979404 cites W2065975840 @default.
• W2158979404 cites W2085807260 @default.
• W2158979404 cites W2090759987 @default.
• W2158979404 cites W2100286113 @default.
• W2158979404 cites W2102862906 @default.
• W2158979404 cites W2125325575 @default.
• W2158979404 cites W2128494605 @default.
• W2158979404 cites W2129713991 @default.
• W2158979404 cites W2132809666 @default.
• W2158979404 cites W2145053281 @default.
• W2158979404 cites W2145333208 @default.
• W2158979404 cites W2145776921 @default.
• W2158979404 cites W2145942833 @default.
• W2158979404 cites W2156904396 @default.
• W2158979404 cites W2165468471 @default.
• W2158979404 cites W2165566422 @default.
• W2158979404 cites W2168649610 @default.
• W2158979404 cites W2171256006 @default.
• W2158979404 cites W2409110149 @default.
• W2158979404 doi "https://doi.org/10.1152/ajpgi.00114.2011" @default.
• W2158979404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3345958" @default.
• W2158979404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22038823" @default.
• W2158979404 hasPublicationYear "2012" @default.
• W2158979404 type Work @default.
• W2158979404 sameAs 2158979404 @default.
• W2158979404 citedByCount "14" @default.
• W2158979404 countsByYear W21589794042013 @default.
• W2158979404 countsByYear W21589794042014 @default.
• W2158979404 countsByYear W21589794042015 @default.
• W2158979404 countsByYear W21589794042016 @default.
• W2158979404 countsByYear W21589794042018 @default.
• W2158979404 countsByYear W21589794042019 @default.
• W2158979404 countsByYear W21589794042020 @default.
• W2158979404 crossrefType "journal-article" @default.
• W2158979404 hasAuthorship W2158979404A5001904860 @default.
• W2158979404 hasAuthorship W2158979404A5015745014 @default.
• W2158979404 hasAuthorship W2158979404A5076458634 @default.
• W2158979404 hasAuthorship W2158979404A5079186811 @default.
• W2158979404 hasBestOaLocation W21589794042 @default.
• W2158979404 hasConcept C112446052 @default.
• W2158979404 hasConcept C126322002 @default.
• W2158979404 hasConcept C134018914 @default.
• W2158979404 hasConcept C185592680 @default.
• W2158979404 hasConcept C2777391703 @default.
• W2158979404 hasConcept C2777622882 @default.
• W2158979404 hasConcept C2778690821 @default.
• W2158979404 hasConcept C2779306644 @default.
• W2158979404 hasConcept C51551487 @default.
• W2158979404 hasConcept C519581460 @default.
• W2158979404 hasConcept C57074206 @default.
• W2158979404 hasConcept C62478195 @default.
• W2158979404 hasConcept C71924100 @default.
• W2158979404 hasConcept C75217442 @default.
• W2158979404 hasConcept C86554907 @default.
• W2158979404 hasConcept C86803240 @default.
• W2158979404 hasConcept C95444343 @default.
• W2158979404 hasConceptScore W2158979404C112446052 @default.
• W2158979404 hasConceptScore W2158979404C126322002 @default.
• W2158979404 hasConceptScore W2158979404C134018914 @default.
• W2158979404 hasConceptScore W2158979404C185592680 @default.
• W2158979404 hasConceptScore W2158979404C2777391703 @default.
• W2158979404 hasConceptScore W2158979404C2777622882 @default.
• W2158979404 hasConceptScore W2158979404C2778690821 @default.

• next