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• W2158981019 abstract "We purified the KH-type splicing regulatory protein (KSRP) as a protein interacting with the 3'-untranslated region (3'-UTR) of the human inducible nitric oxide (iNOS) mRNA. Immunodepletion of KSRP enhanced iNOS 3'-UTR RNA stability in in vitro-degradation assays. In DLD-1 cells overexpressing KSRP cytokine-induced iNOS expression was markedly reduced. In accordance, downregulation of KSRP expression increases iNOS expression by stabilizing iNOS mRNA. Co-immunoprecipitations showed interaction of KSRP with the exosome and tristetraprolin (TTP). To analyze the role of KSRP binding to the 3'-UTR we studied iNOS expression in DLD-1 cells overexpressing a non-binding mutant of KSRP. In these cells, iNOS expression was increased. Mapping of the binding site revealed KSRP interacting with the most 3'-located AU-rich element (ARE) of the human iNOS mRNA. This sequence is also the target for HuR, an iNOS mRNA stabilizing protein. We were able to demonstrate that KSRP and HuR compete for this binding site, and that intracellular binding to the iNOS mRNA was reduced for KSRP and enhanced for HuR after cytokine treatment. Finally, a complex interplay of KSRP with TTP and HuR seems to be essential for iNOS mRNA stabilization after cytokine stimulation." @default.
• W2158981019 created "2016-06-24" @default.
• W2158981019 creator A5023495844 @default.
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• W2158981019 creator A5080433113 @default.
• W2158981019 creator A5082766981 @default.
• W2158981019 date "2005-08-26" @default.
• W2158981019 modified "2023-10-18" @default.
• W2158981019 title "Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR" @default.
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• W2158981019 doi "https://doi.org/10.1093/nar/gki797" @default.
• W2158981019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1192834" @default.
• W2158981019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16126846" @default.
• W2158981019 hasPublicationYear "2005" @default.
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