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• W2158984772 abstract "To evaluate the outcomes of changing immunosuppressive therapy for noninfectious uveitis after failure.Retrospective cohort study.Patients with noninfectious uveitis managed at 2 tertiary uveitis clinics in the United Kingdom and Australia.Participants with a history of using immunosuppressive therapy were identified in clinics, and notes were reviewed by doctors trained in uveitis therapy. Each treatment episode/course (starting or changing a therapy) was identified, and demographic details, clinical characteristics, drug used (second-line immunosuppressive agent [ISA] or biologicals), and drug doses were obtained.For each treatment episode, the reasons for changing therapy, corticosteroid-sparing effects, and control of inflammation were determined.A total of 147 patients were identified who underwent 309 different treatment episodes. Fifty-five percent of patients eventually required a change in treatment after their first treatment episode/course. Forty-five episodes involved switching from one ISA to another, with 50% to 100% of these patients achieving success (prednisolone ≤10 mg and sustained control) with the new ISA. A combination of ISAs were used in 53 episodes, with success being achieved in 50% to 71% of these patients. Biological agents were used in 45 episodes, the most common one being infliximab, which achieved success in 80% of patients.Our data suggest that control of inflammation can be achieved after switching or combining ISAs." @default.
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• W2158984772 date "2014-05-01" @default.
• W2158984772 modified "2023-09-23" @default.
• W2158984772 title "Outcomes of Changing Immunosuppressive Therapy after Treatment Failure in Patients with Noninfectious Uveitis" @default.
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• W2158984772 doi "https://doi.org/10.1016/j.ophtha.2013.11.032" @default.
• W2158984772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24433970" @default.
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