Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158997032> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2158997032 endingPage "579" @default.
- W2158997032 startingPage "569" @default.
- W2158997032 abstract "The objective was to develop a microencapsulation process suitable for the controlled release of an active protein drug. β-glucuronidase was selected as a model protein and a combination of complex coacervation (gelatin/sodium alginate, gelatin/acacia and albumin/acacia) and spray drying was investigated. Coacervates were either spray dried or glutaraldehyde crosslinked to form microcapsules. Polyvinylpyrrolidone (PVP) and polyethylene glycol were investigated as potential coacervate enhancers and stabilizers. β-glucuroni-dase/polymer mixtures were spray dried to determine any polymer protective effects on protein activity. A BÜCHI 190 Spray Drier was used, β-glucur-onidase activity was determined using a Sigma Kit and microcapsule particle size was measured by Accusizer analysis (light blockage). All non-crosslinked coacervates investigated, with the exceptions of albumin/acacia and albumin/ acacia/β-glucuronidase/PVP, were unsuitable for spray drying as they rapidly phase separated and blocked the spray drier nozzle. β-glucuronidase activity in the albumin/acacia coacervates approximated to 99% prior to and 80% following spray drying. This can be compared to activities of approximately 30% and 68% when spray dried alone and with albumin, respectively, and of 18% in albumin/ acacia microcapsules crosslinked with glutaraldehyde. Microcapsule particle size was affected by coacervation pH, additives and spray drying. In vitro β-glucuronidase release was biphasic, with an initial burst release followed by a zero order release phase and continued over the 12 day study period. In conclusion, the spray drying albumin/acacia/PVP method described is useful for the preparation and collection of controlled release microcapsules with minimal loss of β-glucuronidase activity." @default.
- W2158997032 created "2016-06-24" @default.
- W2158997032 creator A5045787186 @default.
- W2158997032 creator A5089510416 @default.
- W2158997032 date "1998-01-01" @default.
- W2158997032 modified "2023-10-14" @default.
- W2158997032 title "β-Glucuronidase activity following complex coacervation and spray drying microencapsulation" @default.
- W2158997032 cites W1490430764 @default.
- W2158997032 cites W1529935442 @default.
- W2158997032 cites W1652618311 @default.
- W2158997032 cites W1964230426 @default.
- W2158997032 cites W1970122022 @default.
- W2158997032 cites W1981442508 @default.
- W2158997032 cites W2004927126 @default.
- W2158997032 cites W2007569156 @default.
- W2158997032 cites W2028098234 @default.
- W2158997032 cites W2030572722 @default.
- W2158997032 cites W2036426995 @default.
- W2158997032 cites W2050151743 @default.
- W2158997032 cites W2091724040 @default.
- W2158997032 cites W2102599376 @default.
- W2158997032 cites W2112381622 @default.
- W2158997032 cites W2120743191 @default.
- W2158997032 cites W2133473300 @default.
- W2158997032 cites W2147649669 @default.
- W2158997032 cites W4243202999 @default.
- W2158997032 cites W95249665 @default.
- W2158997032 doi "https://doi.org/10.3109/02652049809008241" @default.
- W2158997032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9743913" @default.
- W2158997032 hasPublicationYear "1998" @default.
- W2158997032 type Work @default.
- W2158997032 sameAs 2158997032 @default.
- W2158997032 citedByCount "39" @default.
- W2158997032 countsByYear W21589970322012 @default.
- W2158997032 countsByYear W21589970322013 @default.
- W2158997032 countsByYear W21589970322014 @default.
- W2158997032 countsByYear W21589970322015 @default.
- W2158997032 countsByYear W21589970322016 @default.
- W2158997032 countsByYear W21589970322017 @default.
- W2158997032 countsByYear W21589970322018 @default.
- W2158997032 countsByYear W21589970322020 @default.
- W2158997032 countsByYear W21589970322021 @default.
- W2158997032 crossrefType "journal-article" @default.
- W2158997032 hasAuthorship W2158997032A5045787186 @default.
- W2158997032 hasAuthorship W2158997032A5089510416 @default.
- W2158997032 hasConcept C185592680 @default.
- W2158997032 hasConcept C192562407 @default.
- W2158997032 hasConcept C2776125364 @default.
- W2158997032 hasConcept C2776964284 @default.
- W2158997032 hasConcept C2777529624 @default.
- W2158997032 hasConcept C2778823387 @default.
- W2158997032 hasConcept C2779587474 @default.
- W2158997032 hasConcept C2908855275 @default.
- W2158997032 hasConcept C31903555 @default.
- W2158997032 hasConcept C43617362 @default.
- W2158997032 hasConcept C55493867 @default.
- W2158997032 hasConcept C83029808 @default.
- W2158997032 hasConceptScore W2158997032C185592680 @default.
- W2158997032 hasConceptScore W2158997032C192562407 @default.
- W2158997032 hasConceptScore W2158997032C2776125364 @default.
- W2158997032 hasConceptScore W2158997032C2776964284 @default.
- W2158997032 hasConceptScore W2158997032C2777529624 @default.
- W2158997032 hasConceptScore W2158997032C2778823387 @default.
- W2158997032 hasConceptScore W2158997032C2779587474 @default.
- W2158997032 hasConceptScore W2158997032C2908855275 @default.
- W2158997032 hasConceptScore W2158997032C31903555 @default.
- W2158997032 hasConceptScore W2158997032C43617362 @default.
- W2158997032 hasConceptScore W2158997032C55493867 @default.
- W2158997032 hasConceptScore W2158997032C83029808 @default.
- W2158997032 hasIssue "5" @default.
- W2158997032 hasLocation W21589970321 @default.
- W2158997032 hasLocation W21589970322 @default.
- W2158997032 hasOpenAccess W2158997032 @default.
- W2158997032 hasPrimaryLocation W21589970321 @default.
- W2158997032 hasRelatedWork W1975011593 @default.
- W2158997032 hasRelatedWork W2009040121 @default.
- W2158997032 hasRelatedWork W2010812378 @default.
- W2158997032 hasRelatedWork W2062381411 @default.
- W2158997032 hasRelatedWork W2342550517 @default.
- W2158997032 hasRelatedWork W2371433010 @default.
- W2158997032 hasRelatedWork W2376659997 @default.
- W2158997032 hasRelatedWork W2557611963 @default.
- W2158997032 hasRelatedWork W2586819376 @default.
- W2158997032 hasRelatedWork W3080574111 @default.
- W2158997032 hasVolume "15" @default.
- W2158997032 isParatext "false" @default.
- W2158997032 isRetracted "false" @default.
- W2158997032 magId "2158997032" @default.
- W2158997032 workType "article" @default.