Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159034021> ?p ?o ?g. }
- W2159034021 endingPage "1484" @default.
- W2159034021 startingPage "1476" @default.
- W2159034021 abstract "ABSTRACT The therapeutic activity of ceftobiprole medocaril, the prodrug of ceftobiprole, was compared to that of vancomycin, daptomycin, and the combination of a subtherapeutic dose of ceftobiprole and vancomycin in a rat model of infective endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA) (ATCC 43300) or glycopeptide-intermediate Staphylococcus aureus (GISA) (NRS4 and HIP 5836) strains. The minimum bactericidal concentrations of ceftobiprole, vancomycin, and daptomycin at bacterial cell densities similar to those encountered in the cardiac vegetation in the rat endocarditis model were 2, >64, and 8 μg/ml, respectively, for MRSA ATCC 43300 and 4, >64, and 8 μg/ml, respectively, for the GISA strain. Ceftobiprole medocaril administered in doses of 100 mg/kg of body weight given intravenously (i.v.) twice a day (BID) every 8 h (q8h) (equivalent to a human therapeutic dose of ceftobiprole [500 mg given three times a day [TID]) was the most effective monotherapy, eradicating nearly 5 log 10 CFU/g MRSA or 6 log 10 CFU/g GISA organisms from the cardiac vegetation and had the highest incidence of sterile vegetation compared to the other monotherapies in the endocarditis model. In in vitro time-kill studies, synergistic effects were observed with ceftobiprole and vancomycin on MRSA and GISA strains, and in vivo synergy was noted with combinations of subtherapeutic doses of these agents for the same strains. Additionally, sterile vegetations were achieved in 33 and 60%, respectively, of the animals infected with MRSA ATCC 43300 or GISA NRS4 receiving ceftobiprole-vancomycin combination therapy. In summary, ceftobiprole was efficacious both as monotherapy and in combination with vancomycin in treating MRSA and GISA infections in a rat infective endocarditis model and warrants further evaluation." @default.
- W2159034021 created "2016-06-24" @default.
- W2159034021 creator A5006715126 @default.
- W2159034021 creator A5007120471 @default.
- W2159034021 creator A5014053960 @default.
- W2159034021 creator A5018909871 @default.
- W2159034021 creator A5023645521 @default.
- W2159034021 creator A5043311954 @default.
- W2159034021 creator A5047983659 @default.
- W2159034021 creator A5053370661 @default.
- W2159034021 creator A5054418747 @default.
- W2159034021 creator A5077971584 @default.
- W2159034021 creator A5078361934 @default.
- W2159034021 date "2012-03-01" @default.
- W2159034021 modified "2023-10-15" @default.
- W2159034021 title "Synergistic Activity of Ceftobiprole and Vancomycin in a Rat Model of Infective Endocarditis Caused by Methicillin-Resistant and Glycopeptide-Intermediate Staphylococcus aureus" @default.
- W2159034021 cites W1524066693 @default.
- W2159034021 cites W1584013292 @default.
- W2159034021 cites W1869062106 @default.
- W2159034021 cites W1965725897 @default.
- W2159034021 cites W1969980896 @default.
- W2159034021 cites W1980449145 @default.
- W2159034021 cites W1986968369 @default.
- W2159034021 cites W1987270289 @default.
- W2159034021 cites W1990013145 @default.
- W2159034021 cites W2015317905 @default.
- W2159034021 cites W2027422681 @default.
- W2159034021 cites W2036130972 @default.
- W2159034021 cites W2039726036 @default.
- W2159034021 cites W2044087791 @default.
- W2159034021 cites W2052513187 @default.
- W2159034021 cites W2054595873 @default.
- W2159034021 cites W2062970922 @default.
- W2159034021 cites W2067652133 @default.
- W2159034021 cites W2068037991 @default.
- W2159034021 cites W2073981183 @default.
- W2159034021 cites W2074155863 @default.
- W2159034021 cites W2080144242 @default.
- W2159034021 cites W2081253489 @default.
- W2159034021 cites W2082518780 @default.
- W2159034021 cites W2084873537 @default.
- W2159034021 cites W2098764224 @default.
- W2159034021 cites W2099883798 @default.
- W2159034021 cites W2104723420 @default.
- W2159034021 cites W2108072142 @default.
- W2159034021 cites W2112157378 @default.
- W2159034021 cites W2112225194 @default.
- W2159034021 cites W2112898669 @default.
- W2159034021 cites W2116463217 @default.
- W2159034021 cites W2118094416 @default.
- W2159034021 cites W2119190516 @default.
- W2159034021 cites W2123501596 @default.
- W2159034021 cites W2128053708 @default.
- W2159034021 cites W2129898726 @default.
- W2159034021 cites W2131052486 @default.
- W2159034021 cites W2136468593 @default.
- W2159034021 cites W2137097355 @default.
- W2159034021 cites W2137831211 @default.
- W2159034021 cites W2140764008 @default.
- W2159034021 cites W2153056072 @default.
- W2159034021 cites W2155157371 @default.
- W2159034021 cites W2155758384 @default.
- W2159034021 cites W2156783478 @default.
- W2159034021 cites W2157177676 @default.
- W2159034021 cites W2162849130 @default.
- W2159034021 cites W2165496299 @default.
- W2159034021 cites W2166748199 @default.
- W2159034021 cites W2167225395 @default.
- W2159034021 cites W2168550647 @default.
- W2159034021 cites W2169388619 @default.
- W2159034021 cites W2169532129 @default.
- W2159034021 cites W2417572114 @default.
- W2159034021 doi "https://doi.org/10.1128/aac.06057-11" @default.
- W2159034021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3294932" @default.
- W2159034021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22232278" @default.
- W2159034021 hasPublicationYear "2012" @default.
- W2159034021 type Work @default.
- W2159034021 sameAs 2159034021 @default.
- W2159034021 citedByCount "21" @default.
- W2159034021 countsByYear W21590340212012 @default.
- W2159034021 countsByYear W21590340212013 @default.
- W2159034021 countsByYear W21590340212014 @default.
- W2159034021 countsByYear W21590340212015 @default.
- W2159034021 countsByYear W21590340212016 @default.
- W2159034021 countsByYear W21590340212017 @default.
- W2159034021 countsByYear W21590340212019 @default.
- W2159034021 countsByYear W21590340212020 @default.
- W2159034021 countsByYear W21590340212021 @default.
- W2159034021 countsByYear W21590340212023 @default.
- W2159034021 crossrefType "journal-article" @default.
- W2159034021 hasAuthorship W2159034021A5006715126 @default.
- W2159034021 hasAuthorship W2159034021A5007120471 @default.
- W2159034021 hasAuthorship W2159034021A5014053960 @default.
- W2159034021 hasAuthorship W2159034021A5018909871 @default.
- W2159034021 hasAuthorship W2159034021A5023645521 @default.
- W2159034021 hasAuthorship W2159034021A5043311954 @default.
- W2159034021 hasAuthorship W2159034021A5047983659 @default.
- W2159034021 hasAuthorship W2159034021A5053370661 @default.