FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159038466> ?p ?o ?g. }

• W2159038466 endingPage "2571" @default.
• W2159038466 startingPage "2561" @default.
• W2159038466 abstract "Substrate-specific degradation of proteins by the ubiquitin-proteasome pathway is a precise mechanism that controls the abundance of key cell regulators. SCF complexes are a family of E3 ubiquitin ligases that target specific proteins for destruction at the 26S-proteasome. These complexes are composed of three constant polypeptides – Skp1, Cullin1/3 and Roc1/Rbx1– and a fourth variable adapter, the F-box protein. Slimb (Slmb) is a Drosophila F-Box protein that fulfills several roles in development and cell physiology. We analyzed its participation in egg chamber development and found that slmb is required in both the follicle cells and the germline at different stages of oogenesis. We observed that in slmbsomatic clones, morphogenesis of the germarium and encapsulation of the cyst were altered, giving rise to egg chambers with extra germline cells and two oocytes. Furthermore, in slmb somatic clones, we observed ectopic Fasciclin 3 expression, suggesting a delay in follicle cell differentiation,which correlated with the occurrence of ectopic polar cells, lack of interfollicular stalks and mislocalization of the oocyte. Later in oogenesis,Slmb was required in somatic cells to specify the position, size and morphology of dorsal appendages. Mild overactivation of the Dpp pathway caused similar phenotypes that could be antagonized by simultaneous overexpression of Slmb, suggesting that Slmb might normally downregulate the Dpp pathway in follicle cells. Indeed, ectopic expression of a dad-LacZ enhancer trap revealed that the Dpp pathway was upregulated in slmb somatic clones and, consistent with this, ectopic accumulation of the co-Smad protein,Medea, was recorded. By analyzing slmb germline clones, we found that loss of Slmb provoked a reduction in E2f2 and Dp levels, which correlated with misregulation of mitotic cycles during cyst formation, abnormal nurse cell endoreplication and impairment of dumping of the nurse cell content into the oocyte." @default.
• W2159038466 created "2016-06-24" @default.
• W2159038466 creator A5000650663 @default.
• W2159038466 creator A5090229919 @default.
• W2159038466 date "2005-06-01" @default.
• W2159038466 modified "2023-09-23" @default.
• W2159038466 title "Multiple roles of the F-box protein Slimb inDrosophilaegg chamber development" @default.
• W2159038466 cites W1531957421 @default.
• W2159038466 cites W1555563809 @default.
• W2159038466 cites W1580962701 @default.
• W2159038466 cites W1820076796 @default.
• W2159038466 cites W1825701914 @default.
• W2159038466 cites W1826103719 @default.
• W2159038466 cites W1832030339 @default.
• W2159038466 cites W1855259954 @default.
• W2159038466 cites W1892887105 @default.
• W2159038466 cites W1938204331 @default.
• W2159038466 cites W1964517213 @default.
• W2159038466 cites W1966034049 @default.
• W2159038466 cites W1971913477 @default.
• W2159038466 cites W1973564464 @default.
• W2159038466 cites W1974886343 @default.
• W2159038466 cites W1983096415 @default.
• W2159038466 cites W1988367343 @default.
• W2159038466 cites W1997173534 @default.
• W2159038466 cites W1997765248 @default.
• W2159038466 cites W2005812143 @default.
• W2159038466 cites W2012307678 @default.
• W2159038466 cites W2015709484 @default.
• W2159038466 cites W2017995506 @default.
• W2159038466 cites W2021108427 @default.
• W2159038466 cites W2021502605 @default.
• W2159038466 cites W2028776361 @default.
• W2159038466 cites W2033228162 @default.
• W2159038466 cites W2034268892 @default.
• W2159038466 cites W2034466289 @default.
• W2159038466 cites W2037048003 @default.
• W2159038466 cites W2039968082 @default.
• W2159038466 cites W2040576293 @default.
• W2159038466 cites W2047531031 @default.
• W2159038466 cites W2047627641 @default.
• W2159038466 cites W2065633653 @default.
• W2159038466 cites W2070672002 @default.
• W2159038466 cites W2072688355 @default.
• W2159038466 cites W2073658506 @default.
• W2159038466 cites W2076654167 @default.
• W2159038466 cites W2082400881 @default.
• W2159038466 cites W2082937277 @default.
• W2159038466 cites W2090478056 @default.
• W2159038466 cites W2096658690 @default.
• W2159038466 cites W2097255529 @default.
• W2159038466 cites W2104262655 @default.
• W2159038466 cites W2108366666 @default.
• W2159038466 cites W2113538446 @default.
• W2159038466 cites W2114692975 @default.
• W2159038466 cites W2121077625 @default.
• W2159038466 cites W2121436458 @default.
• W2159038466 cites W2123781000 @default.
• W2159038466 cites W2125392305 @default.
• W2159038466 cites W2135482336 @default.
• W2159038466 cites W2139627774 @default.
• W2159038466 cites W2139985100 @default.
• W2159038466 cites W2144792264 @default.
• W2159038466 cites W2147921995 @default.
• W2159038466 cites W2148018780 @default.
• W2159038466 cites W2148121308 @default.
• W2159038466 cites W2150583320 @default.
• W2159038466 cites W2153763344 @default.
• W2159038466 cites W2156086003 @default.
• W2159038466 cites W2159935247 @default.
• W2159038466 cites W2163664843 @default.
• W2159038466 cites W2165116042 @default.
• W2159038466 cites W2166987747 @default.
• W2159038466 cites W2167179274 @default.
• W2159038466 cites W2170634115 @default.
• W2159038466 cites W2171483658 @default.
• W2159038466 cites W2172086325 @default.
• W2159038466 cites W2182819731 @default.
• W2159038466 cites W2308309280 @default.
• W2159038466 cites W2413081924 @default.
• W2159038466 cites W2762075333 @default.
• W2159038466 doi "https://doi.org/10.1242/dev.01839" @default.
• W2159038466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15857915" @default.
• W2159038466 hasPublicationYear "2005" @default.
• W2159038466 type Work @default.
• W2159038466 sameAs 2159038466 @default.
• W2159038466 citedByCount "22" @default.
• W2159038466 countsByYear W21590384662012 @default.
• W2159038466 countsByYear W21590384662013 @default.
• W2159038466 countsByYear W21590384662014 @default.
• W2159038466 countsByYear W21590384662015 @default.
• W2159038466 countsByYear W21590384662016 @default.
• W2159038466 countsByYear W21590384662017 @default.
• W2159038466 countsByYear W21590384662020 @default.
• W2159038466 countsByYear W21590384662021 @default.
• W2159038466 countsByYear W21590384662022 @default.
• W2159038466 crossrefType "journal-article" @default.
• W2159038466 hasAuthorship W2159038466A5000650663 @default.

• next