FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159043609> ?p ?o ?g. }

• W2159043609 endingPage "F748" @default.
• W2159043609 startingPage "F743" @default.
• W2159043609 abstract "Gap junctional coupling of renin-producing cells is of major functional importance for the control of renin synthesis and release. This study was designed to determine the relevance of the vascular gap junction protein connexin 45 (Cx45) for the control of renin expression and secretion. By crossbreeding mice which drive Cre recombinase under the control of the endogenous renin promoter with mice harboring floxed Cx45 gene alleles, we generated viable mice with a deletion of Cx45 in the renin cell lineage. These mice were normotensive, and renin cells in their kidneys were normal with regard to localization and number. Sodium deficiency induced typical recruitment of renin-producing cells along afferent arterioles, whereas sodium overload resulted in a decrease in the number of cells expressing renin. Regulation of renin secretion by perfusion pressure, catecholamines, and angiotensin II from isolated kidneys of mice with renin cell-specific deletion of Cx45 was normal. Analyzing Cx45 promoter activity in cells of the preglomerular arteriolar tree by using mice driving the reporter gene LacZ under the control of the Cx45 promoter revealed strong staining in smooth muscle cells of the media, whereas renin-expressing cells were almost devoid of LacZ staining. Conversely, renin-producing cells, but not vascular smooth muscle cells expressed the gap junction protein Cx40. These findings suggest that Cx45 plays no major functional role in renin-producing cells, probably because the expression of Cx45 is downregulated in these cells. Since renin-producing cells in the adult kidney can reversibly transform into vascular smooth muscle cells and vice versa, our findings on connexin expression indicate that these phenotype switches are paralleled by characteristic reciprocal changes in the transcriptional activity of Cx40 and Cx45 genes." @default.
• W2159043609 created "2016-06-24" @default.
• W2159043609 creator A5002846614 @default.
• W2159043609 creator A5029074504 @default.
• W2159043609 creator A5039496264 @default.
• W2159043609 creator A5039917214 @default.
• W2159043609 creator A5059178679 @default.
• W2159043609 creator A5070999479 @default.
• W2159043609 creator A5086331770 @default.
• W2159043609 date "2011-03-01" @default.
• W2159043609 modified "2023-10-18" @default.
• W2159043609 title "Reciprocal expression of connexin 40 and 45 during phenotypical changes in renin-secreting cells" @default.
• W2159043609 cites W1967166579 @default.
• W2159043609 cites W1970435433 @default.
• W2159043609 cites W1971858657 @default.
• W2159043609 cites W2000575178 @default.
• W2159043609 cites W2004052732 @default.
• W2159043609 cites W2005784527 @default.
• W2159043609 cites W2007290356 @default.
• W2159043609 cites W2022123029 @default.
• W2159043609 cites W2032701963 @default.
• W2159043609 cites W2040181550 @default.
• W2159043609 cites W2061878719 @default.
• W2159043609 cites W2063345683 @default.
• W2159043609 cites W2092223498 @default.
• W2159043609 cites W2097824536 @default.
• W2159043609 cites W2100448566 @default.
• W2159043609 cites W2126811481 @default.
• W2159043609 cites W2130528624 @default.
• W2159043609 cites W2147099282 @default.
• W2159043609 cites W2157988319 @default.
• W2159043609 cites W2287862640 @default.
• W2159043609 cites W2735799190 @default.
• W2159043609 cites W4294216491 @default.
• W2159043609 doi "https://doi.org/10.1152/ajprenal.00647.2010" @default.
• W2159043609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3064136" @default.
• W2159043609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21209011" @default.
• W2159043609 hasPublicationYear "2011" @default.
• W2159043609 type Work @default.
• W2159043609 sameAs 2159043609 @default.
• W2159043609 citedByCount "20" @default.
• W2159043609 countsByYear W21590436092012 @default.
• W2159043609 countsByYear W21590436092013 @default.
• W2159043609 countsByYear W21590436092014 @default.
• W2159043609 countsByYear W21590436092015 @default.
• W2159043609 countsByYear W21590436092017 @default.
• W2159043609 countsByYear W21590436092019 @default.
• W2159043609 countsByYear W21590436092021 @default.
• W2159043609 countsByYear W21590436092022 @default.
• W2159043609 countsByYear W21590436092023 @default.
• W2159043609 crossrefType "journal-article" @default.
• W2159043609 hasAuthorship W2159043609A5002846614 @default.
• W2159043609 hasAuthorship W2159043609A5029074504 @default.
• W2159043609 hasAuthorship W2159043609A5039496264 @default.
• W2159043609 hasAuthorship W2159043609A5039917214 @default.
• W2159043609 hasAuthorship W2159043609A5059178679 @default.
• W2159043609 hasAuthorship W2159043609A5070999479 @default.
• W2159043609 hasAuthorship W2159043609A5086331770 @default.
• W2159043609 hasBestOaLocation W21590436092 @default.
• W2159043609 hasConcept C126322002 @default.
• W2159043609 hasConcept C134018914 @default.
• W2159043609 hasConcept C1491633281 @default.
• W2159043609 hasConcept C153911025 @default.
• W2159043609 hasConcept C158157758 @default.
• W2159043609 hasConcept C189014844 @default.
• W2159043609 hasConcept C198710026 @default.
• W2159043609 hasConcept C2779078858 @default.
• W2159043609 hasConcept C2779395532 @default.
• W2159043609 hasConcept C2780228694 @default.
• W2159043609 hasConcept C2992686903 @default.
• W2159043609 hasConcept C55493867 @default.
• W2159043609 hasConcept C71924100 @default.
• W2159043609 hasConcept C79879829 @default.
• W2159043609 hasConcept C84393581 @default.
• W2159043609 hasConcept C86803240 @default.
• W2159043609 hasConcept C95444343 @default.
• W2159043609 hasConceptScore W2159043609C126322002 @default.
• W2159043609 hasConceptScore W2159043609C134018914 @default.
• W2159043609 hasConceptScore W2159043609C1491633281 @default.
• W2159043609 hasConceptScore W2159043609C153911025 @default.
• W2159043609 hasConceptScore W2159043609C158157758 @default.
• W2159043609 hasConceptScore W2159043609C189014844 @default.
• W2159043609 hasConceptScore W2159043609C198710026 @default.
• W2159043609 hasConceptScore W2159043609C2779078858 @default.
• W2159043609 hasConceptScore W2159043609C2779395532 @default.
• W2159043609 hasConceptScore W2159043609C2780228694 @default.
• W2159043609 hasConceptScore W2159043609C2992686903 @default.
• W2159043609 hasConceptScore W2159043609C55493867 @default.
• W2159043609 hasConceptScore W2159043609C71924100 @default.
• W2159043609 hasConceptScore W2159043609C79879829 @default.
• W2159043609 hasConceptScore W2159043609C84393581 @default.
• W2159043609 hasConceptScore W2159043609C86803240 @default.
• W2159043609 hasConceptScore W2159043609C95444343 @default.
• W2159043609 hasIssue "3" @default.
• W2159043609 hasLocation W21590436091 @default.
• W2159043609 hasLocation W21590436092 @default.
• W2159043609 hasLocation W21590436093 @default.
• W2159043609 hasLocation W21590436094 @default.

• next