FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159049102> ?p ?o ?g. }

• W2159049102 abstract "Hyperoxic exposures are often found in clinical settings of respiratory insufficient patients, although oxygen therapy (>50% O2) can result in the development of acute hyperoxic lung injury within a few days. Upon hyperoxic exposure, the inducible nitric oxide synthase (iNOS) is activated by a variety of proinflammatory cytokines both in vitro and in vivo. In the present study, we used a murine hyperoxic model to evaluate the effects of iNOS deficiency on the inflammatory response. Wild-type and iNOS-deficient mice were exposed to normoxia, 60% O2 or >95% O2 for 72 h. Exposure to >95% O2 resulted in an increased iNOS mRNA and protein expression in the lungs from wild-type mice. No significant effects of iNOS deficiency on cell differential in bronchoalveolar lavage fluid were observed. However, hyperoxia induced a significant increase in total cell count, protein concentration, LDH activity, lipid peroxidation, and TNF-α concentration in the bronchoalveolar lavage fluid compared to iNOS knockout mice. Moreover, binding activity of NF-κB and AP-1 appeared to be higher in wild-type than in iNOS-deficient mice. Taken together, our results provide evidence to suggest that iNOS plays a proinflammatory role in acute hyperoxic lung injury." @default.
• W2159049102 created "2016-06-24" @default.
• W2159049102 creator A5019408836 @default.
• W2159049102 creator A5046528033 @default.
• W2159049102 creator A5048788739 @default.
• W2159049102 creator A5056456336 @default.
• W2159049102 date "2004-09-15" @default.
• W2159049102 modified "2023-10-15" @default.
• W2159049102 title "Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury" @default.
• W2159049102 cites W12312492 @default.
• W2159049102 cites W146001025 @default.
• W2159049102 cites W1481630279 @default.
• W2159049102 cites W1532516694 @default.
• W2159049102 cites W1725300350 @default.
• W2159049102 cites W1800678382 @default.
• W2159049102 cites W1895296940 @default.
• W2159049102 cites W1930369674 @default.
• W2159049102 cites W1964476269 @default.
• W2159049102 cites W1967315269 @default.
• W2159049102 cites W1973018387 @default.
• W2159049102 cites W1981299857 @default.
• W2159049102 cites W1984656331 @default.
• W2159049102 cites W1987821993 @default.
• W2159049102 cites W1992616500 @default.
• W2159049102 cites W1993243592 @default.
• W2159049102 cites W2000040414 @default.
• W2159049102 cites W2005272680 @default.
• W2159049102 cites W2006083342 @default.
• W2159049102 cites W2019522425 @default.
• W2159049102 cites W2020712752 @default.
• W2159049102 cites W2021219700 @default.
• W2159049102 cites W2025166922 @default.
• W2159049102 cites W2032570347 @default.
• W2159049102 cites W2039367580 @default.
• W2159049102 cites W2043787490 @default.
• W2159049102 cites W2050283646 @default.
• W2159049102 cites W2050539139 @default.
• W2159049102 cites W2052283634 @default.
• W2159049102 cites W2054510493 @default.
• W2159049102 cites W2058307341 @default.
• W2159049102 cites W2070022340 @default.
• W2159049102 cites W2075976369 @default.
• W2159049102 cites W2094340805 @default.
• W2159049102 cites W2098198071 @default.
• W2159049102 cites W2109328348 @default.
• W2159049102 cites W2110748275 @default.
• W2159049102 cites W2112686176 @default.
• W2159049102 cites W2112975823 @default.
• W2159049102 cites W2122042960 @default.
• W2159049102 cites W2122515902 @default.
• W2159049102 cites W2122905213 @default.
• W2159049102 cites W2126707512 @default.
• W2159049102 cites W2127992806 @default.
• W2159049102 cites W2150201087 @default.
• W2159049102 cites W2162417589 @default.
• W2159049102 cites W2169654509 @default.
• W2159049102 cites W2209831038 @default.
• W2159049102 cites W2409457420 @default.
• W2159049102 cites W2417056688 @default.
• W2159049102 cites W2474226366 @default.
• W2159049102 cites W2950369001 @default.
• W2159049102 cites W4232534952 @default.
• W2159049102 cites W4238953154 @default.
• W2159049102 cites W4249235652 @default.
• W2159049102 cites W44020636 @default.
• W2159049102 cites W9790566 @default.
• W2159049102 doi "https://doi.org/10.1186/1465-9921-5-11" @default.
• W2159049102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/520822" @default.
• W2159049102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15377396" @default.
• W2159049102 hasPublicationYear "2004" @default.
• W2159049102 type Work @default.
• W2159049102 sameAs 2159049102 @default.
• W2159049102 citedByCount "42" @default.
• W2159049102 countsByYear W21590491022012 @default.
• W2159049102 countsByYear W21590491022013 @default.
• W2159049102 countsByYear W21590491022015 @default.
• W2159049102 countsByYear W21590491022016 @default.
• W2159049102 countsByYear W21590491022017 @default.
• W2159049102 countsByYear W21590491022018 @default.
• W2159049102 countsByYear W21590491022019 @default.
• W2159049102 countsByYear W21590491022020 @default.
• W2159049102 countsByYear W21590491022021 @default.
• W2159049102 countsByYear W21590491022022 @default.
• W2159049102 countsByYear W21590491022023 @default.
• W2159049102 crossrefType "journal-article" @default.
• W2159049102 hasAuthorship W2159049102A5019408836 @default.
• W2159049102 hasAuthorship W2159049102A5046528033 @default.
• W2159049102 hasAuthorship W2159049102A5048788739 @default.
• W2159049102 hasAuthorship W2159049102A5056456336 @default.
• W2159049102 hasBestOaLocation W21590491021 @default.
• W2159049102 hasConcept C126322002 @default.
• W2159049102 hasConcept C164027704 @default.
• W2159049102 hasConcept C185592680 @default.
• W2159049102 hasConcept C203014093 @default.
• W2159049102 hasConcept C2776914184 @default.
• W2159049102 hasConcept C2777622882 @default.
• W2159049102 hasConcept C2777714996 @default.
• W2159049102 hasConcept C2777961210 @default.
• W2159049102 hasConcept C2780672939 @default.
• W2159049102 hasConcept C519581460 @default.

• next