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- W2159050782 abstract "Abstract Glycine and γ‐aminobutyric acid (GABA) are the major inhibitory transmitters of the mammalian retina, and bipolar cells receive GABAergic and glycinergic inhibition from multiple amacrine cell types. Here we evaluated the functional properties and subunit composition of glycine receptors (GlyRs) in bipolar cells. Patch‐clamp recordings were performed from retinal slices of wild‐type, GlyRα1‐deficient ( Glra1 spd‐ot ) and GlyRα3‐deficient ( Glra3 –/– ) mice. Whole‐cell currents following glycine application and spontaneous inhibitory postsynaptic currents (IPSCs) were analysed. During the recordings the cells were filled with Alexa 488 and, thus, unequivocally identified. Glycine‐induced currents of bipolar cells were picrotoxinin‐insensitive and thus represent heteromeric channels composed of α and β subunits. Glycine‐induced currents and IPSCs were absent from all bipolar cells of Glra1 spd‐ot mice, indicating that GlyRα1 is an essential subunit of bipolar cell GlyRs. By comparing IPSCs of bipolar cells in wild‐type and Glra3 –/– mice, no statistically significant differences were found. OFF‐cone bipolar (CB) cells receive a strong glycinergic input from AII amacrine cells, that is preferentially based on the fast α1β‐containing channels (mean decay time constant τ = 5.9 ± 1.4 ms). We did not observe glycinergic IPSCs in ON‐CB cells and could elicit only small, if any, glycinergic currents. Rod bipolar cells receive a prominent glycinergic input that is mainly mediated by α1β‐containing channels (τ = 5.5 ± 1.6 ms). Slow IPSCs, the characteristic of GlyRs containing the α2 subunit, were not observed in bipolar cells. Thus, different bipolar cell types receive kinetically fast glycinergic inputs, preferentially mediated by GlyRs composed of α1 and β subunits." @default.
- W2159050782 created "2016-06-24" @default.
- W2159050782 creator A5014029024 @default.
- W2159050782 creator A5056156940 @default.
- W2159050782 creator A5077408587 @default.
- W2159050782 date "2006-01-01" @default.
- W2159050782 modified "2023-10-10" @default.
- W2159050782 title "Characterization of the glycinergic input to bipolar cells of the mouse retina" @default.
- W2159050782 cites W1507855610 @default.
- W2159050782 cites W1509513803 @default.
- W2159050782 cites W1512084986 @default.
- W2159050782 cites W1519429960 @default.
- W2159050782 cites W1526360825 @default.
- W2159050782 cites W1562806058 @default.
- W2159050782 cites W1592727056 @default.
- W2159050782 cites W1593584737 @default.
- W2159050782 cites W1630702110 @default.
- W2159050782 cites W1710559804 @default.
- W2159050782 cites W1728707763 @default.
- W2159050782 cites W1740455381 @default.
- W2159050782 cites W1774637004 @default.
- W2159050782 cites W1829475219 @default.
- W2159050782 cites W1905325352 @default.
- W2159050782 cites W1908448863 @default.
- W2159050782 cites W1920017598 @default.
- W2159050782 cites W1957270349 @default.
- W2159050782 cites W1976584289 @default.
- W2159050782 cites W1979126279 @default.
- W2159050782 cites W1980839404 @default.
- W2159050782 cites W1981111905 @default.
- W2159050782 cites W1984537495 @default.
- W2159050782 cites W1990779469 @default.
- W2159050782 cites W1991183604 @default.
- W2159050782 cites W1995268545 @default.
- W2159050782 cites W1999490342 @default.
- W2159050782 cites W1999612489 @default.
- W2159050782 cites W2002502745 @default.
- W2159050782 cites W2002660309 @default.
- W2159050782 cites W2005829345 @default.
- W2159050782 cites W2006409404 @default.
- W2159050782 cites W2006475992 @default.
- W2159050782 cites W2007147751 @default.
- W2159050782 cites W2007659653 @default.
- W2159050782 cites W2021842829 @default.
- W2159050782 cites W2024866634 @default.
- W2159050782 cites W2030417118 @default.
- W2159050782 cites W2034262791 @default.
- W2159050782 cites W2037371195 @default.
- W2159050782 cites W2037945455 @default.
- W2159050782 cites W2046297486 @default.
- W2159050782 cites W2048473975 @default.
- W2159050782 cites W2049767843 @default.
- W2159050782 cites W2050357426 @default.
- W2159050782 cites W2051879169 @default.
- W2159050782 cites W2055059211 @default.
- W2159050782 cites W2055059343 @default.
- W2159050782 cites W2057807470 @default.
- W2159050782 cites W2059818802 @default.
- W2159050782 cites W2063640158 @default.
- W2159050782 cites W2067018082 @default.
- W2159050782 cites W2072759014 @default.
- W2159050782 cites W2073762758 @default.
- W2159050782 cites W2077516044 @default.
- W2159050782 cites W2078647525 @default.
- W2159050782 cites W2080207066 @default.
- W2159050782 cites W2093811657 @default.
- W2159050782 cites W2100862669 @default.
- W2159050782 cites W2109613652 @default.
- W2159050782 cites W2110107835 @default.
- W2159050782 cites W2114972922 @default.
- W2159050782 cites W2119051861 @default.
- W2159050782 cites W2122348590 @default.
- W2159050782 cites W2133652497 @default.
- W2159050782 cites W2140556250 @default.
- W2159050782 cites W2141631265 @default.
- W2159050782 cites W2153283555 @default.
- W2159050782 cites W2320248287 @default.
- W2159050782 cites W2602548552 @default.
- W2159050782 cites W2605123890 @default.
- W2159050782 cites W4231781093 @default.
- W2159050782 cites W98874919 @default.
- W2159050782 doi "https://doi.org/10.1111/j.1460-9568.2005.04557.x" @default.
- W2159050782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16420443" @default.
- W2159050782 hasPublicationYear "2006" @default.
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