FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159099334> ?p ?o ?g. }

• W2159099334 endingPage "533" @default.
• W2159099334 startingPage "533" @default.
• W2159099334 abstract "Vitamin C at high concentrations is toxic to cancer cells in vitro. Early clinical studies of vitamin C in patients with terminal cancer suggested clinical benefit, but 2 double-blind, placebo-controlled trials showed none. However, these studies used different routes of administration.To determine whether plasma vitamin C concentrations vary substantially with the route of administration.Dose concentration studies and pharmacokinetic modeling.Academic medical center.17 healthy hospitalized volunteers.Vitamin C plasma and urine concentrations were measured after administration of oral and intravenous doses at a dose range of 0.015 to 1.25 g, and plasma concentrations were calculated for a dose range of 1 to 100 g.Peak plasma vitamin C concentrations were higher after administration of intravenous doses than after administration of oral doses (P < 0.001), and the difference increased according to dose. Vitamin C at a dose of 1.25 g administered orally produced mean (+/-sd) peak plasma concentrations of 134.8 +/- 20.6 micromol/L compared with 885 +/- 201.2 micromol/L for intravenous administration. For the maximum tolerated oral dose of 3 g every 4 hours, pharmacokinetic modeling predicted peak plasma vitamin C concentrations of 220 micromol/L and 13 400 micromol/L for a 50-g intravenous dose. Peak predicted urine concentrations of vitamin C from intravenous administration were 140-fold higher than those from maximum oral doses.Patient data are not available to confirm pharmacokinetic modeling at high doses and in patients with cancer.Oral vitamin C produces plasma concentrations that are tightly controlled. Only intravenous administration of vitamin C produces high plasma and urine concentrations that might have antitumor activity. Because efficacy of vitamin C treatment cannot be judged from clinical trials that use only oral dosing, the role of vitamin C in cancer treatment should be reevaluated." @default.
• W2159099334 created "2016-06-24" @default.
• W2159099334 creator A5011055578 @default.
• W2159099334 creator A5033936594 @default.
• W2159099334 creator A5035480324 @default.
• W2159099334 creator A5050388054 @default.
• W2159099334 creator A5061700636 @default.
• W2159099334 creator A5065626281 @default.
• W2159099334 creator A5077568448 @default.
• W2159099334 creator A5077649055 @default.
• W2159099334 date "2004-04-06" @default.
• W2159099334 modified "2023-10-03" @default.
• W2159099334 title "Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use" @default.
• W2159099334 cites W117575723 @default.
• W2159099334 cites W120346798 @default.
• W2159099334 cites W1487536884 @default.
• W2159099334 cites W1489783301 @default.
• W2159099334 cites W1571564529 @default.
• W2159099334 cites W1960166151 @default.
• W2159099334 cites W1968097361 @default.
• W2159099334 cites W1978407431 @default.
• W2159099334 cites W1990223276 @default.
• W2159099334 cites W2010756713 @default.
• W2159099334 cites W2011352354 @default.
• W2159099334 cites W2033862041 @default.
• W2159099334 cites W2035109840 @default.
• W2159099334 cites W2040961287 @default.
• W2159099334 cites W2049457454 @default.
• W2159099334 cites W2069930390 @default.
• W2159099334 cites W2070532527 @default.
• W2159099334 cites W2302641817 @default.
• W2159099334 cites W2332542469 @default.
• W2159099334 cites W2333401880 @default.
• W2159099334 cites W2799035555 @default.
• W2159099334 cites W3484683 @default.
• W2159099334 doi "https://doi.org/10.7326/0003-4819-140-7-200404060-00010" @default.
• W2159099334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15068981" @default.
• W2159099334 hasPublicationYear "2004" @default.
• W2159099334 type Work @default.
• W2159099334 sameAs 2159099334 @default.
• W2159099334 citedByCount "738" @default.
• W2159099334 countsByYear W21590993342012 @default.
• W2159099334 countsByYear W21590993342013 @default.
• W2159099334 countsByYear W21590993342014 @default.
• W2159099334 countsByYear W21590993342015 @default.
• W2159099334 countsByYear W21590993342016 @default.
• W2159099334 countsByYear W21590993342017 @default.
• W2159099334 countsByYear W21590993342018 @default.
• W2159099334 countsByYear W21590993342019 @default.
• W2159099334 countsByYear W21590993342020 @default.
• W2159099334 countsByYear W21590993342021 @default.
• W2159099334 countsByYear W21590993342022 @default.
• W2159099334 countsByYear W21590993342023 @default.
• W2159099334 crossrefType "journal-article" @default.
• W2159099334 hasAuthorship W2159099334A5011055578 @default.
• W2159099334 hasAuthorship W2159099334A5033936594 @default.
• W2159099334 hasAuthorship W2159099334A5035480324 @default.
• W2159099334 hasAuthorship W2159099334A5050388054 @default.
• W2159099334 hasAuthorship W2159099334A5061700636 @default.
• W2159099334 hasAuthorship W2159099334A5065626281 @default.
• W2159099334 hasAuthorship W2159099334A5077568448 @default.
• W2159099334 hasAuthorship W2159099334A5077649055 @default.
• W2159099334 hasBestOaLocation W21590993341 @default.
• W2159099334 hasConcept C112705442 @default.
• W2159099334 hasConcept C126322002 @default.
• W2159099334 hasConcept C142724271 @default.
• W2159099334 hasConcept C162156334 @default.
• W2159099334 hasConcept C181389837 @default.
• W2159099334 hasConcept C204787440 @default.
• W2159099334 hasConcept C27081682 @default.
• W2159099334 hasConcept C2776093070 @default.
• W2159099334 hasConcept C2776940978 @default.
• W2159099334 hasConcept C2777056448 @default.
• W2159099334 hasConcept C2780026642 @default.
• W2159099334 hasConcept C71924100 @default.
• W2159099334 hasConcept C98274493 @default.
• W2159099334 hasConceptScore W2159099334C112705442 @default.
• W2159099334 hasConceptScore W2159099334C126322002 @default.
• W2159099334 hasConceptScore W2159099334C142724271 @default.
• W2159099334 hasConceptScore W2159099334C162156334 @default.
• W2159099334 hasConceptScore W2159099334C181389837 @default.
• W2159099334 hasConceptScore W2159099334C204787440 @default.
• W2159099334 hasConceptScore W2159099334C27081682 @default.
• W2159099334 hasConceptScore W2159099334C2776093070 @default.
• W2159099334 hasConceptScore W2159099334C2776940978 @default.
• W2159099334 hasConceptScore W2159099334C2777056448 @default.
• W2159099334 hasConceptScore W2159099334C2780026642 @default.
• W2159099334 hasConceptScore W2159099334C71924100 @default.
• W2159099334 hasConceptScore W2159099334C98274493 @default.
• W2159099334 hasIssue "7" @default.
• W2159099334 hasLocation W21590993341 @default.
• W2159099334 hasLocation W21590993342 @default.
• W2159099334 hasOpenAccess W2159099334 @default.
• W2159099334 hasPrimaryLocation W21590993341 @default.
• W2159099334 hasRelatedWork W1555144605 @default.
• W2159099334 hasRelatedWork W1903755941 @default.
• W2159099334 hasRelatedWork W2001333918 @default.
• W2159099334 hasRelatedWork W2009397585 @default.

• next