Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159110897> ?p ?o ?g. }
- W2159110897 endingPage "635" @default.
- W2159110897 startingPage "623" @default.
- W2159110897 abstract "The proteolytic activity of a disintegrin and metalloproteinase 10 (ADAM10) regulates cell-fate decisions in Drosophila and mouse embryos. However, in utero lethality of ADAM10−/− mice has prevented examination of ADAM10 cleavage events in lymphocytes. To investigate their role in B cell development, we generated B cell–specific ADAM10 knockout mice. Intriguingly, deletion of ADAM10 prevented development of the entire marginal zone B cell (MZB) lineage. Additionally, cleavage of the low affinity IgE receptor, CD23, was profoundly impaired, but subsequent experiments demonstrated that ADAM10 regulates CD23 cleavage and MZB development by independent mechanisms. Development of MZBs is dependent on Notch2 signaling, which requires proteolysis of the Notch2 receptor by a previously unidentified proteinase. Further experiments revealed that Notch2 signaling is severely impaired in ADAM10-null B cells. Thus, ADAM10 critically regulates MZB development by initiating Notch2 signaling. This study identifies ADAM10 as the in vivo CD23 sheddase and an important regulator of B cell development. Moreover, it has important implications for the treatment of numerous CD23- and Notch-mediated pathologies, ranging from allergy to cancer." @default.
- W2159110897 created "2016-06-24" @default.
- W2159110897 creator A5017042797 @default.
- W2159110897 creator A5033492600 @default.
- W2159110897 creator A5049658773 @default.
- W2159110897 creator A5054373028 @default.
- W2159110897 creator A5056762896 @default.
- W2159110897 creator A5066813354 @default.
- W2159110897 creator A5067445666 @default.
- W2159110897 creator A5070494006 @default.
- W2159110897 creator A5071281268 @default.
- W2159110897 creator A5076748684 @default.
- W2159110897 creator A5081360617 @default.
- W2159110897 date "2010-02-15" @default.
- W2159110897 modified "2023-09-26" @default.
- W2159110897 title "ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo" @default.
- W2159110897 cites W1524115127 @default.
- W2159110897 cites W1589830662 @default.
- W2159110897 cites W1637561641 @default.
- W2159110897 cites W1811742220 @default.
- W2159110897 cites W1884274647 @default.
- W2159110897 cites W1920765599 @default.
- W2159110897 cites W1969414295 @default.
- W2159110897 cites W1978819143 @default.
- W2159110897 cites W1980191945 @default.
- W2159110897 cites W1981148940 @default.
- W2159110897 cites W1981873656 @default.
- W2159110897 cites W1983360116 @default.
- W2159110897 cites W1992660677 @default.
- W2159110897 cites W1995863606 @default.
- W2159110897 cites W1997801717 @default.
- W2159110897 cites W2008295869 @default.
- W2159110897 cites W2017719081 @default.
- W2159110897 cites W2018400989 @default.
- W2159110897 cites W2019007505 @default.
- W2159110897 cites W2035543586 @default.
- W2159110897 cites W2039243852 @default.
- W2159110897 cites W2040640809 @default.
- W2159110897 cites W2041572974 @default.
- W2159110897 cites W2044692976 @default.
- W2159110897 cites W2046267268 @default.
- W2159110897 cites W2070854099 @default.
- W2159110897 cites W2072219853 @default.
- W2159110897 cites W2080523191 @default.
- W2159110897 cites W2082849113 @default.
- W2159110897 cites W2084016153 @default.
- W2159110897 cites W2094288695 @default.
- W2159110897 cites W2094371537 @default.
- W2159110897 cites W2098503611 @default.
- W2159110897 cites W2099005282 @default.
- W2159110897 cites W2109627278 @default.
- W2159110897 cites W2112622667 @default.
- W2159110897 cites W2119005151 @default.
- W2159110897 cites W2129270491 @default.
- W2159110897 cites W2129961058 @default.
- W2159110897 cites W2130038947 @default.
- W2159110897 cites W2133170726 @default.
- W2159110897 cites W2139995217 @default.
- W2159110897 cites W2140553945 @default.
- W2159110897 cites W2147110025 @default.
- W2159110897 cites W2149152049 @default.
- W2159110897 cites W2151909421 @default.
- W2159110897 cites W2164213095 @default.
- W2159110897 cites W2166611044 @default.
- W2159110897 cites W2167403404 @default.
- W2159110897 cites W2169177386 @default.
- W2159110897 cites W2169466938 @default.
- W2159110897 cites W2171623512 @default.
- W2159110897 cites W2171728173 @default.
- W2159110897 cites W343303420 @default.
- W2159110897 doi "https://doi.org/10.1084/jem.20091990" @default.
- W2159110897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2839139" @default.
- W2159110897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20156974" @default.
- W2159110897 hasPublicationYear "2010" @default.
- W2159110897 type Work @default.
- W2159110897 sameAs 2159110897 @default.
- W2159110897 citedByCount "138" @default.
- W2159110897 countsByYear W21591108972012 @default.
- W2159110897 countsByYear W21591108972013 @default.
- W2159110897 countsByYear W21591108972014 @default.
- W2159110897 countsByYear W21591108972015 @default.
- W2159110897 countsByYear W21591108972016 @default.
- W2159110897 countsByYear W21591108972017 @default.
- W2159110897 countsByYear W21591108972018 @default.
- W2159110897 countsByYear W21591108972019 @default.
- W2159110897 countsByYear W21591108972020 @default.
- W2159110897 countsByYear W21591108972021 @default.
- W2159110897 countsByYear W21591108972022 @default.
- W2159110897 countsByYear W21591108972023 @default.
- W2159110897 crossrefType "journal-article" @default.
- W2159110897 hasAuthorship W2159110897A5017042797 @default.
- W2159110897 hasAuthorship W2159110897A5033492600 @default.
- W2159110897 hasAuthorship W2159110897A5049658773 @default.
- W2159110897 hasAuthorship W2159110897A5054373028 @default.
- W2159110897 hasAuthorship W2159110897A5056762896 @default.
- W2159110897 hasAuthorship W2159110897A5066813354 @default.
- W2159110897 hasAuthorship W2159110897A5067445666 @default.
- W2159110897 hasAuthorship W2159110897A5070494006 @default.