Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159114219> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2159114219 abstract "This study was designed to determine whether the end-systolic pressure-length relationship (ESPLR) reflects changes in regional contractility during the imposition of graded ischemia, and whether it is modified by diltiazem during propofol anesthesia. Seven beagles were anesthetized and instrumented to measure left ventricular pressure and subendocardial segment lengths (sonomicrometry) in the region of the left anterior descending (LAD) and circumflex (LC) arteries. Afterload was increased by the tightening of a snare around the descending thoracic aorta. Pressure-length loops were constructed and the slope of the ESPLR and the x-axis intercept, Lo, were calculated. Graded ischemia of the apical myocardium only was accomplished by the tightening of a micrometer-controlled snare around the LAD to produce Critical Constriction (CC), Ischemia 1 and 2 (I1, I2), and Total Occlusion (TO). In the basal LC region, LAD ischemia had no effect on either the ESPLR slope or Lo. In contrast, the ESPLR slope in the LAD area was decreased by ischemia at I1 (-40%), increased at TO (+69%), and unchanged at CC and I2, and was reduced by diltiazem at CC and I2 (-31% and -36%, respectively). The LAD ESPLR Lo was increased by ischemia by 64% and 61% at I2, and 91% and 122% at TO, before and after diltiazem, respectively. In the LC region, diltiazem decreased systolic shortening and the ESPLR slope. These results indicate that diltiazem has negative inotropic properties in both ischemic and nonischemic areas. Also, Lo is not a constant and must always be redetermined for every intervention. In the absence of ischemia, the ESPLR may be a reliable measure of myocardial contractility.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2159114219 created "2016-06-24" @default.
- W2159114219 creator A5025495671 @default.
- W2159114219 creator A5081277884 @default.
- W2159114219 creator A5087055739 @default.
- W2159114219 creator A5000883438 @default.
- W2159114219 date "1992-10-01" @default.
- W2159114219 modified "2023-09-27" @default.
- W2159114219 title "Canine end-systolic pressure-length relationships: Depressed by diltiazem, invalidated by ischemia" @default.
- W2159114219 cites W1963721828 @default.
- W2159114219 cites W1965563383 @default.
- W2159114219 cites W1973040683 @default.
- W2159114219 cites W1975105992 @default.
- W2159114219 cites W1991440794 @default.
- W2159114219 cites W2001978130 @default.
- W2159114219 cites W2021487280 @default.
- W2159114219 cites W2054434546 @default.
- W2159114219 cites W2065973646 @default.
- W2159114219 cites W2067161021 @default.
- W2159114219 cites W2076103635 @default.
- W2159114219 cites W2077551325 @default.
- W2159114219 cites W2078199847 @default.
- W2159114219 cites W2082661415 @default.
- W2159114219 cites W2112068874 @default.
- W2159114219 cites W2119229486 @default.
- W2159114219 cites W2128177147 @default.
- W2159114219 cites W2129966847 @default.
- W2159114219 cites W2145950740 @default.
- W2159114219 cites W2159263356 @default.
- W2159114219 cites W2272154350 @default.
- W2159114219 cites W2285797245 @default.
- W2159114219 cites W2461153702 @default.
- W2159114219 cites W72966750 @default.
- W2159114219 doi "https://doi.org/10.1016/1053-0770(92)90103-e" @default.
- W2159114219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1421071" @default.
- W2159114219 hasPublicationYear "1992" @default.
- W2159114219 type Work @default.
- W2159114219 sameAs 2159114219 @default.
- W2159114219 citedByCount "6" @default.
- W2159114219 crossrefType "journal-article" @default.
- W2159114219 hasAuthorship W2159114219A5000883438 @default.
- W2159114219 hasAuthorship W2159114219A5025495671 @default.
- W2159114219 hasAuthorship W2159114219A5081277884 @default.
- W2159114219 hasAuthorship W2159114219A5087055739 @default.
- W2159114219 hasConcept C123576724 @default.
- W2159114219 hasConcept C126322002 @default.
- W2159114219 hasConcept C155710745 @default.
- W2159114219 hasConcept C164705383 @default.
- W2159114219 hasConcept C178853913 @default.
- W2159114219 hasConcept C2775938633 @default.
- W2159114219 hasConcept C2776741139 @default.
- W2159114219 hasConcept C39124391 @default.
- W2159114219 hasConcept C39133596 @default.
- W2159114219 hasConcept C42219234 @default.
- W2159114219 hasConcept C519063684 @default.
- W2159114219 hasConcept C541997718 @default.
- W2159114219 hasConcept C71924100 @default.
- W2159114219 hasConceptScore W2159114219C123576724 @default.
- W2159114219 hasConceptScore W2159114219C126322002 @default.
- W2159114219 hasConceptScore W2159114219C155710745 @default.
- W2159114219 hasConceptScore W2159114219C164705383 @default.
- W2159114219 hasConceptScore W2159114219C178853913 @default.
- W2159114219 hasConceptScore W2159114219C2775938633 @default.
- W2159114219 hasConceptScore W2159114219C2776741139 @default.
- W2159114219 hasConceptScore W2159114219C39124391 @default.
- W2159114219 hasConceptScore W2159114219C39133596 @default.
- W2159114219 hasConceptScore W2159114219C42219234 @default.
- W2159114219 hasConceptScore W2159114219C519063684 @default.
- W2159114219 hasConceptScore W2159114219C541997718 @default.
- W2159114219 hasConceptScore W2159114219C71924100 @default.
- W2159114219 hasLocation W21591142191 @default.
- W2159114219 hasLocation W21591142192 @default.
- W2159114219 hasOpenAccess W2159114219 @default.
- W2159114219 hasPrimaryLocation W21591142191 @default.
- W2159114219 hasRelatedWork W188447618 @default.
- W2159114219 hasRelatedWork W1982081382 @default.
- W2159114219 hasRelatedWork W1991185704 @default.
- W2159114219 hasRelatedWork W1992539960 @default.
- W2159114219 hasRelatedWork W1999897615 @default.
- W2159114219 hasRelatedWork W2073819811 @default.
- W2159114219 hasRelatedWork W2130518171 @default.
- W2159114219 hasRelatedWork W2159114219 @default.
- W2159114219 hasRelatedWork W2159362665 @default.
- W2159114219 hasRelatedWork W651355564 @default.
- W2159114219 isParatext "false" @default.
- W2159114219 isRetracted "false" @default.
- W2159114219 magId "2159114219" @default.
- W2159114219 workType "article" @default.