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• W2159133028 abstract "The precise mode of action of lithium carbonate on the central nervous system (CNS) is still far from clear. However, there have been some speculations based on the electroencephalogram (EEG) findings to suggest that lithium has both cortical and subcortical effect on the CNS.1 Rochford et al.2 found that 36.8% of young adult psychiatric patients showed neurological abnormalities, but only 5% of normal controls showed such deficit. However, they found no neurological impairment, whether diffuse or localized, including EEG abnormalities, among patients with affective disorders. This investigation, which included 65 patients of both sexes and extended over a period of 1.5 yr was intended to examine the earlier claims3–5 that CNS dysfunction plays an important role in the pathogenesis of functional psychiatric disorders. These findings have important implications in that one may anticipate a higher incidence of lithium-induced neurotoxicity in the treatment of psychiatric patients suffering from other than primary affective disorders.6 This article reviews the neurological complications arising from lithium carbonate treatment of primary affective disorders and schizoaffective disorders." @default.
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• W2159133028 date "1980-09-01" @default.
• W2159133028 modified "2023-10-18" @default.
• W2159133028 title "Neurological side effects of lithium: Organic brain syndrome, seizures, extrapyramidal side effects, and EEG changes" @default.
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• W2159133028 doi "https://doi.org/10.1016/0010-440x(80)90013-9" @default.
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