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- W2159164794 abstract "Active compounds from natural products have been widely studied. The anti-tumor effects of 13-acetoxysarcocrassolide isolated from Formosan soft coral Sarcophyton crassocaule on bladder cancer cells were examined in this study. An MTT assay showed that 13-acetoxysarcocrassolide was cytotoxic to bladder female transitional cancer (BFTC) cells. We determined that the BFTC cells underwent cell death through apoptosis by flow cytometry. Due to the highly-migratory nature of the BFTC cells, the ability of 13-acetoxysarcocrassolide to stop their migration was assessed by a wound healing assay. To determine which proteins were affected in the BFTC cells upon treatment, a comparative proteomic analysis was performed. By LC-MS/MS analysis, we identified that 19 proteins were up-regulated and eight were down-regulated. Seven of the proteins were confirmed by western blotting analysis. This study reveals clues to the potential mechanism of the cytotoxic effects of 13-acetoxysarcocrassolide on BFTC cells. Moreover, it suggests that PPT1 and hnRNP F could be new biomarkers for bladder cancer. The results of this study are also helpful for the diagnosis, progression monitoring and therapeutic strategies of transitional cell tumors." @default.
- W2159164794 created "2016-06-24" @default.
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- W2159164794 date "2011-12-13" @default.
- W2159164794 modified "2023-09-23" @default.
- W2159164794 title "An Investigation into the Cytotoxic Effects of 13-Acetoxysarcocrassolide from the Soft Coral Sarcophyton crassocaule on Bladder Cancer Cells" @default.
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- W2159164794 doi "https://doi.org/10.3390/md9122622" @default.
- W2159164794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280580" @default.
- W2159164794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22363243" @default.
- W2159164794 hasPublicationYear "2011" @default.
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