FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159193483> ?p ?o ?g. }

• W2159193483 endingPage "4712" @default.
• W2159193483 startingPage "4700" @default.
• W2159193483 abstract "AbstractUpon infection, the herpes simplex virus (HSV) transcriptional activator VP16 directs the formation of a multiprotein-DNA complex—the VP16-induced complex—with two cellular proteins, the host cell factor HCF-1 and the POU domain transcription factor Oct-1, on TAATGARAT-containing sequences found in the promoters of HSV immediate-early genes. HSV VP16 contains carboxy-terminal sequences important for transcriptional activation and a central conserved core that is important for VP16-induced complex assembly. On its own, VP16 displays little, if any, sequence-specific DNA-binding activity. We show here that, within the VP16-induced complex, however, the VP16 core has an important role in DNA binding. Mutation of basic residues on the surface of the VP16 core reveals a novel DNA-binding surface with essential residues which are conserved among VP16 orthologs. These results illuminate how, through association with DNA, VP16 is able to interpret cis-regulatory signals in the DNA to direct the assembly of a multiprotein-DNA transcriptional regulatory complex. ACKNOWLEDGMENTSWe thank X. Cheng for discussions; A. Bubulya for help with the in vivo transcriptional activation studies; C. Sanders for advice on chemical DNA sequencing; L. Joshua-Tor and M. Wang for help with the VP16 structural similarity analysis; X. Zhao for HeLa cell nuclear extract; N. Hernandez, L. Joshua-Tor, A. Stenlund, and J. Wysocka for comments on the manuscript; J. Duffy and P. Renna for artwork; and J. Reader for help with manuscript preparation.These studies were funded by U.S. Public Health Service grant CA-13106 from the National Cancer Institute." @default.
• W2159193483 created "2016-06-24" @default.
• W2159193483 creator A5043292394 @default.
• W2159193483 creator A5078797727 @default.
• W2159193483 creator A5084518084 @default.
• W2159193483 creator A5090933877 @default.
• W2159193483 date "2001-07-01" @default.
• W2159193483 modified "2023-10-10" @default.
• W2159193483 title "DNA Recognition by the Herpes Simplex Virus Transactivator VP16: a Novel DNA-Binding Structure" @default.
• W2159193483 cites W14142522 @default.
• W2159193483 cites W1495349824 @default.
• W2159193483 cites W1507006450 @default.
• W2159193483 cites W1561297384 @default.
• W2159193483 cites W1742513880 @default.
• W2159193483 cites W1754561827 @default.
• W2159193483 cites W1882875086 @default.
• W2159193483 cites W1954192059 @default.
• W2159193483 cites W1963839975 @default.
• W2159193483 cites W1967002699 @default.
• W2159193483 cites W1968707958 @default.
• W2159193483 cites W1973751044 @default.
• W2159193483 cites W1979423222 @default.
• W2159193483 cites W1979647722 @default.
• W2159193483 cites W1979772713 @default.
• W2159193483 cites W1983397972 @default.
• W2159193483 cites W1984751884 @default.
• W2159193483 cites W1988293580 @default.
• W2159193483 cites W1994664042 @default.
• W2159193483 cites W1998440551 @default.
• W2159193483 cites W2004474490 @default.
• W2159193483 cites W2004689349 @default.
• W2159193483 cites W2010353576 @default.
• W2159193483 cites W2013607556 @default.
• W2159193483 cites W2015418243 @default.
• W2159193483 cites W2022058405 @default.
• W2159193483 cites W2030185192 @default.
• W2159193483 cites W2050079285 @default.
• W2159193483 cites W2052280808 @default.
• W2159193483 cites W2072683091 @default.
• W2159193483 cites W2077673061 @default.
• W2159193483 cites W2079572279 @default.
• W2159193483 cites W2080051006 @default.
• W2159193483 cites W2089315523 @default.
• W2159193483 cites W2091879363 @default.
• W2159193483 cites W2105014300 @default.
• W2159193483 cites W2106315897 @default.
• W2159193483 cites W2130702042 @default.
• W2159193483 cites W2132992871 @default.
• W2159193483 cites W2136906322 @default.
• W2159193483 cites W2138319809 @default.
• W2159193483 cites W2143142379 @default.
• W2159193483 cites W2151639225 @default.
• W2159193483 cites W2153017169 @default.
• W2159193483 cites W2158150465 @default.
• W2159193483 cites W2160826909 @default.
• W2159193483 cites W2165864695 @default.
• W2159193483 cites W2167379325 @default.
• W2159193483 cites W2168896166 @default.
• W2159193483 cites W2178678932 @default.
• W2159193483 cites W2285107724 @default.
• W2159193483 doi "https://doi.org/10.1128/mcb.21.14.4700-4712.2001" @default.
• W2159193483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/87145" @default.
• W2159193483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11416146" @default.
• W2159193483 hasPublicationYear "2001" @default.
• W2159193483 type Work @default.
• W2159193483 sameAs 2159193483 @default.
• W2159193483 citedByCount "35" @default.
• W2159193483 countsByYear W21591934832013 @default.
• W2159193483 countsByYear W21591934832015 @default.
• W2159193483 countsByYear W21591934832016 @default.
• W2159193483 countsByYear W21591934832018 @default.
• W2159193483 countsByYear W21591934832019 @default.
• W2159193483 countsByYear W21591934832020 @default.
• W2159193483 countsByYear W21591934832021 @default.
• W2159193483 countsByYear W21591934832022 @default.
• W2159193483 countsByYear W21591934832023 @default.
• W2159193483 crossrefType "journal-article" @default.
• W2159193483 hasAuthorship W2159193483A5043292394 @default.
• W2159193483 hasAuthorship W2159193483A5078797727 @default.
• W2159193483 hasAuthorship W2159193483A5084518084 @default.
• W2159193483 hasAuthorship W2159193483A5090933877 @default.
• W2159193483 hasBestOaLocation W21591934831 @default.
• W2159193483 hasConcept C101762097 @default.
• W2159193483 hasConcept C104317684 @default.
• W2159193483 hasConcept C121587040 @default.
• W2159193483 hasConcept C1292079 @default.
• W2159193483 hasConcept C138885662 @default.
• W2159193483 hasConcept C150194340 @default.
• W2159193483 hasConcept C153911025 @default.
• W2159193483 hasConcept C179926584 @default.
• W2159193483 hasConcept C196287685 @default.
• W2159193483 hasConcept C33987129 @default.
• W2159193483 hasConcept C41895202 @default.
• W2159193483 hasConcept C54355233 @default.
• W2159193483 hasConcept C552990157 @default.
• W2159193483 hasConcept C84982370 @default.
• W2159193483 hasConcept C86339819 @default.
• W2159193483 hasConcept C86803240 @default.

• next