FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159193708> ?p ?o ?g. }

• W2159193708 endingPage "642" @default.
• W2159193708 startingPage "642" @default.
• W2159193708 abstract "<h3>Background</h3> The possibility that substantial heterogeneity in metabolic abnormalities exists in moderately obese individuals has not been emphasized in studies of the effect of obesity on morbidity and mortality. We tested the hypothesis that risk factors for type 2 diabetes mellitus and cardiovascular disease vary dramatically in moderately obese individuals as a function of differences in a specific measure of insulin sensitivity. <h3>Methods</h3> Participants included 211 apparently healthy, obese (body mass index [calculated as weight in kilograms divided by height in meters squared], 30.0-34.9) volunteers for weight loss studies. Main outcome measures included insulin-mediated glucose uptake as quantified by the insulin suppression test and metabolic variables known to increase the risk for type 2 diabetes and cardiovascular disease. <h3>Results</h3> Insulin sensitivity varied 6-fold. When compared with the most insulin-sensitive third, the most insulin-resistant third of the population had significantly higher (<i>P</i><.001) systolic and diastolic blood pressure (139 ± 20 vs 123 ± 18 mm Hg, and 83 ± 3 vs 75 ± 10 mm Hg, respectively), higher fasting and 2-hour oral glucose load concentrations (103 ± 11 vs 95 ± 11 mg/dL [5.7 ± 0.6 vs 5.3 ± 0.6 mmol/L], and 139 ± 30 vs 104 ± 19 mg/dL [7.7 ± 1.7 vs 5.8 ± 1.1 mmol/L], respectively), higher plasma triglyceride concentrations (198 ± 105 vs 114 ± 51 mg/dL [2.2 ± 1.2 vs 1.3 ± 0.6 mmol/L]), lower plasma high-density lipoprotein cholesterol concentrations (41 ± 9 vs 50 ± 13 mg/dL [1.1 ± 0.2 vs 1.3 ± 0.3 mmol/L]), and more prevalent impaired glucose tolerance (47% vs 2%). <h3>Conclusions</h3> The magnitude of risk factors for type 2 diabetes and cardiovascular disease varies markedly in moderately obese individuals as a function of differences in degree of insulin sensitivity. Because not all moderately obese individuals are at similar risk for developing type 2 diabetes and cardiovascular disease, intensive therapeutic interventions should be addressed to the insulin-resistant subset of this population." @default.
• W2159193708 created "2016-06-24" @default.
• W2159193708 creator A5005299025 @default.
• W2159193708 creator A5007064966 @default.
• W2159193708 creator A5045366155 @default.
• W2159193708 creator A5047102463 @default.
• W2159193708 date "2007-04-09" @default.
• W2159193708 modified "2023-10-11" @default.
• W2159193708 title "Heterogeneity in the Prevalence of Risk Factors for Cardiovascular Disease and Type 2 Diabetes Mellitus in Obese Individuals" @default.
• W2159193708 cites W1964127395 @default.
• W2159193708 cites W1967959933 @default.
• W2159193708 cites W1969831395 @default.
• W2159193708 cites W1975390269 @default.
• W2159193708 cites W1978171764 @default.
• W2159193708 cites W1985469212 @default.
• W2159193708 cites W1992748772 @default.
• W2159193708 cites W1994281353 @default.
• W2159193708 cites W1999381960 @default.
• W2159193708 cites W2011871953 @default.
• W2159193708 cites W2015591615 @default.
• W2159193708 cites W2021946345 @default.
• W2159193708 cites W2033704972 @default.
• W2159193708 cites W2040064285 @default.
• W2159193708 cites W2062078854 @default.
• W2159193708 cites W2065193629 @default.
• W2159193708 cites W2068343705 @default.
• W2159193708 cites W2074199548 @default.
• W2159193708 cites W2078511984 @default.
• W2159193708 cites W2078721766 @default.
• W2159193708 cites W2079398589 @default.
• W2159193708 cites W2092713555 @default.
• W2159193708 cites W2098316337 @default.
• W2159193708 cites W2098667370 @default.
• W2159193708 cites W2099789512 @default.
• W2159193708 cites W2100990638 @default.
• W2159193708 cites W2120741267 @default.
• W2159193708 cites W2123503963 @default.
• W2159193708 cites W2128023946 @default.
• W2159193708 cites W2139226057 @default.
• W2159193708 cites W2156536882 @default.
• W2159193708 cites W2165836510 @default.
• W2159193708 cites W2165884492 @default.
• W2159193708 cites W2185461071 @default.
• W2159193708 cites W2189592079 @default.
• W2159193708 cites W2319850088 @default.
• W2159193708 cites W2323202746 @default.
• W2159193708 cites W2334309509 @default.
• W2159193708 cites W2337133379 @default.
• W2159193708 cites W2412358696 @default.
• W2159193708 cites W2916596946 @default.
• W2159193708 doi "https://doi.org/10.1001/archinte.167.7.642" @default.
• W2159193708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17420421" @default.
• W2159193708 hasPublicationYear "2007" @default.
• W2159193708 type Work @default.
• W2159193708 sameAs 2159193708 @default.
• W2159193708 citedByCount "175" @default.
• W2159193708 countsByYear W21591937082012 @default.
• W2159193708 countsByYear W21591937082013 @default.
• W2159193708 countsByYear W21591937082014 @default.
• W2159193708 countsByYear W21591937082015 @default.
• W2159193708 countsByYear W21591937082016 @default.
• W2159193708 countsByYear W21591937082017 @default.
• W2159193708 countsByYear W21591937082018 @default.
• W2159193708 countsByYear W21591937082019 @default.
• W2159193708 countsByYear W21591937082020 @default.
• W2159193708 countsByYear W21591937082021 @default.
• W2159193708 countsByYear W21591937082022 @default.
• W2159193708 countsByYear W21591937082023 @default.
• W2159193708 crossrefType "journal-article" @default.
• W2159193708 hasAuthorship W2159193708A5005299025 @default.
• W2159193708 hasAuthorship W2159193708A5007064966 @default.
• W2159193708 hasAuthorship W2159193708A5045366155 @default.
• W2159193708 hasAuthorship W2159193708A5047102463 @default.
• W2159193708 hasConcept C126322002 @default.
• W2159193708 hasConcept C134018914 @default.
• W2159193708 hasConcept C2777180221 @default.
• W2159193708 hasConcept C2778163477 @default.
• W2159193708 hasConcept C2778913445 @default.
• W2159193708 hasConcept C2779306644 @default.
• W2159193708 hasConcept C2780221984 @default.
• W2159193708 hasConcept C2908647359 @default.
• W2159193708 hasConcept C2910068830 @default.
• W2159193708 hasConcept C511355011 @default.
• W2159193708 hasConcept C555293320 @default.
• W2159193708 hasConcept C71924100 @default.
• W2159193708 hasConcept C84393581 @default.
• W2159193708 hasConcept C99454951 @default.
• W2159193708 hasConceptScore W2159193708C126322002 @default.
• W2159193708 hasConceptScore W2159193708C134018914 @default.
• W2159193708 hasConceptScore W2159193708C2777180221 @default.
• W2159193708 hasConceptScore W2159193708C2778163477 @default.
• W2159193708 hasConceptScore W2159193708C2778913445 @default.
• W2159193708 hasConceptScore W2159193708C2779306644 @default.
• W2159193708 hasConceptScore W2159193708C2780221984 @default.
• W2159193708 hasConceptScore W2159193708C2908647359 @default.
• W2159193708 hasConceptScore W2159193708C2910068830 @default.
• W2159193708 hasConceptScore W2159193708C511355011 @default.
• W2159193708 hasConceptScore W2159193708C555293320 @default.

• next