Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159219188> ?p ?o ?g. }
- W2159219188 endingPage "927" @default.
- W2159219188 startingPage "920" @default.
- W2159219188 abstract "Polymorphisms in the gene that encodes the vitamin D receptor (VDR) may influence the host response to Mycobacterium tuberculosis infection.In a Peruvian community with a high incidence of tuberculosis (TB), VDR TaqI and FokI polymorphisms were compared among 103 patients with pulmonary TB and 206 matched healthy control subjects. Associations of VDR polymorphisms with treatment outcome were analyzed among 78 patients undergoing treatment of pulmonary TB.Sputum mycobacterial culture and auramine stain conversions were significantly faster among participants with the FokI FF genotype, compared with participants with the non-FF genotypes. Sputum culture conversion was faster among participants with the TaqI Tt genotype, compared with those with the TT genotype. Increased probability of culture conversion during TB treatment was independently associated with the TaqI Tt genotype (age- and sex-adjusted relative risk, 4.28; 95% confidence interval, 1.88-9.75; P = .001). VDR polymorphisms were not significantly associated with susceptibility to TB in the case-control study.VDR gene polymorphisms are associated with the time to sputum culture and auramine stain conversion during TB treatment. To our knowledge, the present study is the first report of a specific host gene influence on the outcome of TB treatment. These findings demonstrate the potential clinical relevance of immunomodulatory functions of vitamin D metabolites acting via the VDR in the host response against pulmonary TB." @default.
- W2159219188 created "2016-06-24" @default.
- W2159219188 creator A5011607410 @default.
- W2159219188 creator A5017057356 @default.
- W2159219188 creator A5020552854 @default.
- W2159219188 creator A5026741727 @default.
- W2159219188 creator A5038472989 @default.
- W2159219188 creator A5040912618 @default.
- W2159219188 creator A5057621778 @default.
- W2159219188 creator A5081318074 @default.
- W2159219188 date "2004-09-01" @default.
- W2159219188 modified "2023-10-15" @default.
- W2159219188 title "Association between Vitamin D Receptor Gene Polymorphisms and Response to Treatment of Pulmonary Tuberculosis" @default.
- W2159219188 cites W116503477 @default.
- W2159219188 cites W137727250 @default.
- W2159219188 cites W1588120420 @default.
- W2159219188 cites W167069796 @default.
- W2159219188 cites W1818948961 @default.
- W2159219188 cites W1966102891 @default.
- W2159219188 cites W1970910747 @default.
- W2159219188 cites W1977824993 @default.
- W2159219188 cites W1980052547 @default.
- W2159219188 cites W2009180025 @default.
- W2159219188 cites W2019796070 @default.
- W2159219188 cites W2027513534 @default.
- W2159219188 cites W2034457488 @default.
- W2159219188 cites W2053157117 @default.
- W2159219188 cites W2057122918 @default.
- W2159219188 cites W2058275239 @default.
- W2159219188 cites W2078520607 @default.
- W2159219188 cites W2084190995 @default.
- W2159219188 cites W2099265922 @default.
- W2159219188 cites W2102354280 @default.
- W2159219188 cites W2106201929 @default.
- W2159219188 cites W2130445180 @default.
- W2159219188 cites W2141094416 @default.
- W2159219188 cites W2143351205 @default.
- W2159219188 cites W2145788769 @default.
- W2159219188 cites W2146349024 @default.
- W2159219188 cites W2152906249 @default.
- W2159219188 cites W2153680447 @default.
- W2159219188 cites W2163127018 @default.
- W2159219188 cites W2356247052 @default.
- W2159219188 cites W2400050383 @default.
- W2159219188 cites W263381061 @default.
- W2159219188 doi "https://doi.org/10.1086/423212" @default.
- W2159219188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15295697" @default.
- W2159219188 hasPublicationYear "2004" @default.
- W2159219188 type Work @default.
- W2159219188 sameAs 2159219188 @default.
- W2159219188 citedByCount "146" @default.
- W2159219188 countsByYear W21592191882012 @default.
- W2159219188 countsByYear W21592191882013 @default.
- W2159219188 countsByYear W21592191882014 @default.
- W2159219188 countsByYear W21592191882015 @default.
- W2159219188 countsByYear W21592191882016 @default.
- W2159219188 countsByYear W21592191882017 @default.
- W2159219188 countsByYear W21592191882018 @default.
- W2159219188 countsByYear W21592191882019 @default.
- W2159219188 countsByYear W21592191882020 @default.
- W2159219188 countsByYear W21592191882021 @default.
- W2159219188 countsByYear W21592191882022 @default.
- W2159219188 countsByYear W21592191882023 @default.
- W2159219188 crossrefType "journal-article" @default.
- W2159219188 hasAuthorship W2159219188A5011607410 @default.
- W2159219188 hasAuthorship W2159219188A5017057356 @default.
- W2159219188 hasAuthorship W2159219188A5020552854 @default.
- W2159219188 hasAuthorship W2159219188A5026741727 @default.
- W2159219188 hasAuthorship W2159219188A5038472989 @default.
- W2159219188 hasAuthorship W2159219188A5040912618 @default.
- W2159219188 hasAuthorship W2159219188A5057621778 @default.
- W2159219188 hasAuthorship W2159219188A5081318074 @default.
- W2159219188 hasBestOaLocation W21592191881 @default.
- W2159219188 hasConcept C104317684 @default.
- W2159219188 hasConcept C124490489 @default.
- W2159219188 hasConcept C126322002 @default.
- W2159219188 hasConcept C135763542 @default.
- W2159219188 hasConcept C142724271 @default.
- W2159219188 hasConcept C146304588 @default.
- W2159219188 hasConcept C149737253 @default.
- W2159219188 hasConcept C179639408 @default.
- W2159219188 hasConcept C203014093 @default.
- W2159219188 hasConcept C2776301714 @default.
- W2159219188 hasConcept C2777975735 @default.
- W2159219188 hasConcept C2779105492 @default.
- W2159219188 hasConcept C2779912665 @default.
- W2159219188 hasConcept C2781069245 @default.
- W2159219188 hasConcept C2781308329 @default.
- W2159219188 hasConcept C54355233 @default.
- W2159219188 hasConcept C71924100 @default.
- W2159219188 hasConcept C86803240 @default.
- W2159219188 hasConcept C90924648 @default.
- W2159219188 hasConceptScore W2159219188C104317684 @default.
- W2159219188 hasConceptScore W2159219188C124490489 @default.
- W2159219188 hasConceptScore W2159219188C126322002 @default.
- W2159219188 hasConceptScore W2159219188C135763542 @default.
- W2159219188 hasConceptScore W2159219188C142724271 @default.
- W2159219188 hasConceptScore W2159219188C146304588 @default.