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- W2159221444 abstract "Recovery of consciousness following severe brain injuries can occur over long time intervals. Importantly, evolving cognitive recovery can be strongly dissociated from motor recovery in some individuals, resulting in underestimation of cognitive capacities. Common mechanisms of cerebral dysfunction that arise at the neuronal population level may explain slow functional recoveries from severe brain injuries. This review proposes a mesocircuit model that predicts specific roles for different structural and dynamic changes that may occur gradually during recovery. Recent functional neuroimaging studies that operationally identify varying levels of awareness, memory and other higher brain functions in patients with no behavioral evidence of these cognitive capacities are discussed. Measuring evolving changes in underlying brain function and dynamics post-injury and post-treatment frames future investigative work." @default.
- W2159221444 created "2016-06-24" @default.
- W2159221444 creator A5091863587 @default.
- W2159221444 date "2010-01-01" @default.
- W2159221444 modified "2023-10-14" @default.
- W2159221444 title "Recovery of consciousness after brain injury: a mesocircuit hypothesis" @default.
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- W2159221444 doi "https://doi.org/10.1016/j.tins.2009.11.002" @default.
- W2159221444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2931585" @default.
- W2159221444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19954851" @default.
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