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• W2159226235 startingPage "3394" @default.
• W2159226235 abstract "Apolipoprotein E (apoE) is highly expressed in adipose tissue and adipocytes in which its expression is regulated by peroxisome proliferator–activated receptor (PPAR)-γ agonists and tumor necrosis factor–α. There is, however, no information regarding a role for endogenous apoE in differentiated adipocyte function. In this report, we define a novel role for apoE in modulating adipocyte lipid metabolism. ApoE−/− mice have less body fat and smaller adipocytes compared with wild-type controls. Freshly isolated adipose tissue from apoE−/− mice contains lower levels of triglyceride and free fatty acid, and these differences are maintained in cultured adipocytes derived from preadipocytes. Adenoviral expression of apoE in apoE−/−-cultured adipocytes increases triglyceride and fatty acid content. During incubation with apoE-containing triglyceride-rich lipoproteins, apoE−/− adipose tissue accumulates less triglyceride than wild type. The absence of apoE expression in primary cultured adipocytes also leads to changes in the expression of genes involved in the metabolism/turnover of fatty acids and the triglyceride droplet. Markers of adipocyte differentiation were lower in freshly isolated and cultured apoE−/− adipocytes. Importantly, PPAR-γ–mediated changes in lipid content and gene expression are markedly altered in cultured apoE−/− adipocytes. These results establish a novel role for endogenous apoE in adipocyte lipid metabolism and have implications for constructing an integrated model of adipocyte physiology in health and disease." @default.
• W2159226235 created "2016-06-24" @default.
• W2159226235 creator A5056424666 @default.
• W2159226235 creator A5059544618 @default.
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• W2159226235 date "2006-12-01" @default.
• W2159226235 modified "2023-10-03" @default.
• W2159226235 title "Endogenous ApoE Expression Modulates Adipocyte Triglyceride Content and Turnover" @default.
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• W2159226235 doi "https://doi.org/10.2337/db06-0354" @default.
• W2159226235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17130485" @default.
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