FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159249597> ?p ?o ?g. }

• W2159249597 endingPage "322" @default.
• W2159249597 startingPage "311" @default.
• W2159249597 abstract "Dipeptidyl peptidase IV (DPPIV) is a cell surface peptidase expressed by normal melanocytes, epithelial cells, and other cells. Malignant cells, including melanomas and carcinomas, frequently lose or alter DPPIV cell surface expression. Loss of DPPIV expression occurs during melanoma progression at a stage where transformed melanocytes become independent of exogenous growth factors for survival. Tetracycline-inducible expression vectors were constructed to express DPPIV in human melanoma cells. Reexpressing DPPIV in melanoma cells at or below levels expressed by normal melanocytes induced a profound change in phenotype that was characteristic of normal melanocytes. DPPIV expression led to a loss of tumorigenicity, anchorage-independent growth, a reversal in a block in differentiation, and an acquired dependence on exogenous growth factors for cell survival. Suppression of tumorigenicity and reversal of a block in differentiation were dependent on serine protease activity, assessed using mutant DPPIV molecules containing serine-->alanine substitutions. Surprisingly, dependence on exogenous growth factors was not dependent on serine protease activity. Reexpression of either wild-type or mutant DPPIV rescued expression of a second putative cell surface serine peptidase, fibroblast activation protein alpha, which can form a heterodimer with DPPIV. This observation suggests that rescue of fibroblast activation protein alpha may play a role in regulating growth of melanocytic cells. These results support the view that downregulation of DPPIV is an important early event in the pathogenesis of melanoma." @default.
• W2159249597 created "2016-06-24" @default.
• W2159249597 creator A5004840192 @default.
• W2159249597 creator A5006339833 @default.
• W2159249597 creator A5008267130 @default.
• W2159249597 creator A5084264987 @default.
• W2159249597 date "1999-08-02" @default.
• W2159249597 modified "2023-10-13" @default.
• W2159249597 title "A Role for Dipeptidyl Peptidase IV in Suppressing the Malignant Phenotype of Melanocytic Cells" @default.
• W2159249597 cites W1507745533 @default.
• W2159249597 cites W1562916770 @default.
• W2159249597 cites W1567505077 @default.
• W2159249597 cites W1608936927 @default.
• W2159249597 cites W1952342873 @default.
• W2159249597 cites W1964818072 @default.
• W2159249597 cites W1966846160 @default.
• W2159249597 cites W1975258154 @default.
• W2159249597 cites W1976831807 @default.
• W2159249597 cites W1980384590 @default.
• W2159249597 cites W1985824081 @default.
• W2159249597 cites W1995358920 @default.
• W2159249597 cites W2005275397 @default.
• W2159249597 cites W2005991858 @default.
• W2159249597 cites W2026847762 @default.
• W2159249597 cites W2030873144 @default.
• W2159249597 cites W2036585235 @default.
• W2159249597 cites W2036968856 @default.
• W2159249597 cites W2045715263 @default.
• W2159249597 cites W2048430011 @default.
• W2159249597 cites W2054748843 @default.
• W2159249597 cites W2055166662 @default.
• W2159249597 cites W2063278411 @default.
• W2159249597 cites W2068961038 @default.
• W2159249597 cites W2077504048 @default.
• W2159249597 cites W2086662659 @default.
• W2159249597 cites W21039076 @default.
• W2159249597 cites W2106289339 @default.
• W2159249597 cites W2128898204 @default.
• W2159249597 cites W2131706101 @default.
• W2159249597 cites W2137432475 @default.
• W2159249597 cites W2169035807 @default.
• W2159249597 cites W2169951035 @default.
• W2159249597 cites W2209977038 @default.
• W2159249597 cites W2404184823 @default.
• W2159249597 cites W2407050102 @default.
• W2159249597 cites W2473173632 @default.
• W2159249597 cites W4285719527 @default.
• W2159249597 doi "https://doi.org/10.1084/jem.190.3.311" @default.
• W2159249597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2195594" @default.
• W2159249597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10430620" @default.
• W2159249597 hasPublicationYear "1999" @default.
• W2159249597 type Work @default.
• W2159249597 sameAs 2159249597 @default.
• W2159249597 citedByCount "181" @default.
• W2159249597 countsByYear W21592495972012 @default.
• W2159249597 countsByYear W21592495972013 @default.
• W2159249597 countsByYear W21592495972014 @default.
• W2159249597 countsByYear W21592495972015 @default.
• W2159249597 countsByYear W21592495972016 @default.
• W2159249597 countsByYear W21592495972017 @default.
• W2159249597 countsByYear W21592495972018 @default.
• W2159249597 countsByYear W21592495972019 @default.
• W2159249597 countsByYear W21592495972020 @default.
• W2159249597 countsByYear W21592495972021 @default.
• W2159249597 countsByYear W21592495972022 @default.
• W2159249597 countsByYear W21592495972023 @default.
• W2159249597 crossrefType "journal-article" @default.
• W2159249597 hasAuthorship W2159249597A5004840192 @default.
• W2159249597 hasAuthorship W2159249597A5006339833 @default.
• W2159249597 hasAuthorship W2159249597A5008267130 @default.
• W2159249597 hasAuthorship W2159249597A5084264987 @default.
• W2159249597 hasBestOaLocation W21592495971 @default.
• W2159249597 hasConcept C111798993 @default.
• W2159249597 hasConcept C121608353 @default.
• W2159249597 hasConcept C134018914 @default.
• W2159249597 hasConcept C153911025 @default.
• W2159249597 hasConcept C156490143 @default.
• W2159249597 hasConcept C181199279 @default.
• W2159249597 hasConcept C2776714187 @default.
• W2159249597 hasConcept C2777180221 @default.
• W2159249597 hasConcept C2777658100 @default.
• W2159249597 hasConcept C2777807008 @default.
• W2159249597 hasConcept C2781469919 @default.
• W2159249597 hasConcept C502942594 @default.
• W2159249597 hasConcept C54355233 @default.
• W2159249597 hasConcept C55493867 @default.
• W2159249597 hasConcept C555293320 @default.
• W2159249597 hasConcept C62112901 @default.
• W2159249597 hasConcept C81885089 @default.
• W2159249597 hasConcept C86803240 @default.
• W2159249597 hasConcept C95444343 @default.
• W2159249597 hasConceptScore W2159249597C111798993 @default.
• W2159249597 hasConceptScore W2159249597C121608353 @default.
• W2159249597 hasConceptScore W2159249597C134018914 @default.
• W2159249597 hasConceptScore W2159249597C153911025 @default.
• W2159249597 hasConceptScore W2159249597C156490143 @default.
• W2159249597 hasConceptScore W2159249597C181199279 @default.
• W2159249597 hasConceptScore W2159249597C2776714187 @default.

• next