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• W2159251820 abstract "1. The metabolism of p-cymene was studied in rats and guinea-pigs.2. Following intragastric or inhalation dosage (100mg/kg) urinary metabolite excretion was nearly complete within 48h, amounting to 60–80% dose. The inhalation experiments gave the lowest values.3. 18 urinary metabolites were detected and identified. Of these, rats did not excrete two and guinea-pigs did not excrete a third.4. No ring-hydroxylation of p-cymene was detected in rats, but guinea-pigs formed small amounts of carvacrol and hydroxycarvacrol.5. Oxidation of both the methyl and isopropyl groups of p-cymene occurred extensively in both species. The following types of metabolites were formed: monohydric alcohols, diols, mono- and di-carboxylic acids and hydroxyacids. Conjugation with glycine of the cumic acid formed was extensive in guinea-pigs." @default.
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• W2159251820 date "1983-01-01" @default.
• W2159251820 modified "2023-09-26" @default.
• W2159251820 title "p-Cymene metabolism in rats and guinea-pigs" @default.
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• W2159251820 doi "https://doi.org/10.3109/00498258309052290" @default.
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