FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159254316> ?p ?o ?g. }

• W2159254316 endingPage "128" @default.
• W2159254316 startingPage "120" @default.
• W2159254316 abstract "Citrullinated proteins are the products of a posttranslational process in which arginine residues undergo modification into citrulline residues when catalyzed by peptidylarginine deiminases (PADs) in a calcium ion-dependent manner. In our previous report, PAD2 expressed mainly in the rat cerebrum became activated early in the neurodegenerative process. To elucidate the involvement of protein citrullination in human neuronal degeneration, we examined whether citrullinated proteins are produced during Alzheimer's disease (AD). By Western blot analysis with antimodified citrulline antibody, citrullinated proteins of varied molecular weights were detected in hippocampal tissues from patients with AD but not normal humans. Two of the citrullinated proteins were identified as vimentin and glial fibrillary acidic protein (GFAP) by using two-dimensional gel electrophoresis and MALDI-TOF mass spectrometry. Interestingly, PAD2 was detected in hippocampal extracts from AD and normal brains, but the amount of PAD2 in the AD tissue was markedly greater. Histochemical analysis revealed citrullinated proteins throughout the hippocampus, especially in the dentate gyrus and stratum radiatum of CA1 and CA2 areas. However, no citrullinated proteins were detected in the normal hippocampus. PAD2 immunoreactivity was also ubiquitous throughout both the AD and the normal hippocampal areas. PAD2 enrichment coincided well with citrullinated protein positivity. Double immunofluorescence staining revealed that citrullinated protein- and PAD2-positive cells also coincided with GFAP-positive cells, but not all GFAP-positive cells were positive for PAD2. As with GFAP, which is an astrocyte-specific marker protein, PAD2 is distributed mainly in astrocytes. These collective results, the abnormal accumulation of citrullinated proteins and abnormal activation of PAD2 in hippocampi of patients with AD, strongly suggest that PAD has an important role in the onset and progression of AD and that citrullinated proteins may become a useful marker for human neurodegenerative diseases. © 2005 Wiley-Liss, Inc." @default.
• W2159254316 created "2016-06-24" @default.
• W2159254316 creator A5005028382 @default.
• W2159254316 creator A5011294638 @default.
• W2159254316 creator A5016882797 @default.
• W2159254316 creator A5024641774 @default.
• W2159254316 creator A5032709788 @default.
• W2159254316 creator A5032826032 @default.
• W2159254316 creator A5048388392 @default.
• W2159254316 creator A5050310210 @default.
• W2159254316 creator A5050515032 @default.
• W2159254316 creator A5052940866 @default.
• W2159254316 creator A5090343584 @default.
• W2159254316 date "2005-01-01" @default.
• W2159254316 modified "2023-10-16" @default.
• W2159254316 title "Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease" @default.
• W2159254316 cites W1500939789 @default.
• W2159254316 cites W1504864654 @default.
• W2159254316 cites W1514133613 @default.
• W2159254316 cites W1593204115 @default.
• W2159254316 cites W1918768783 @default.
• W2159254316 cites W1967612722 @default.
• W2159254316 cites W1969696977 @default.
• W2159254316 cites W1970100138 @default.
• W2159254316 cites W1979406476 @default.
• W2159254316 cites W1980325059 @default.
• W2159254316 cites W1981000616 @default.
• W2159254316 cites W1982650478 @default.
• W2159254316 cites W1986413832 @default.
• W2159254316 cites W1990756176 @default.
• W2159254316 cites W1993014997 @default.
• W2159254316 cites W1994244586 @default.
• W2159254316 cites W1995734706 @default.
• W2159254316 cites W1996985500 @default.
• W2159254316 cites W1997920604 @default.
• W2159254316 cites W1997923201 @default.
• W2159254316 cites W1998528712 @default.
• W2159254316 cites W2001665185 @default.
• W2159254316 cites W2010694257 @default.
• W2159254316 cites W2011740038 @default.
• W2159254316 cites W2017212166 @default.
• W2159254316 cites W2019469604 @default.
• W2159254316 cites W2033573660 @default.
• W2159254316 cites W2035052662 @default.
• W2159254316 cites W2038011107 @default.
• W2159254316 cites W2038902835 @default.
• W2159254316 cites W2040068123 @default.
• W2159254316 cites W2051252146 @default.
• W2159254316 cites W2055040525 @default.
• W2159254316 cites W2060231586 @default.
• W2159254316 cites W2065147052 @default.
• W2159254316 cites W2067903005 @default.
• W2159254316 cites W2100837269 @default.
• W2159254316 cites W2101108802 @default.
• W2159254316 cites W2125110523 @default.
• W2159254316 cites W2149489524 @default.
• W2159254316 cites W2151898539 @default.
• W2159254316 cites W2265600915 @default.
• W2159254316 cites W2725718031 @default.
• W2159254316 cites W3034352680 @default.
• W2159254316 cites W4210999100 @default.
• W2159254316 cites W4244678912 @default.
• W2159254316 doi "https://doi.org/10.1002/jnr.20431" @default.
• W2159254316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15704193" @default.
• W2159254316 hasPublicationYear "2005" @default.
• W2159254316 type Work @default.
• W2159254316 sameAs 2159254316 @default.
• W2159254316 citedByCount "222" @default.
• W2159254316 countsByYear W21592543162012 @default.
• W2159254316 countsByYear W21592543162013 @default.
• W2159254316 countsByYear W21592543162014 @default.
• W2159254316 countsByYear W21592543162015 @default.
• W2159254316 countsByYear W21592543162016 @default.
• W2159254316 countsByYear W21592543162017 @default.
• W2159254316 countsByYear W21592543162018 @default.
• W2159254316 countsByYear W21592543162019 @default.
• W2159254316 countsByYear W21592543162020 @default.
• W2159254316 countsByYear W21592543162021 @default.
• W2159254316 countsByYear W21592543162022 @default.
• W2159254316 countsByYear W21592543162023 @default.
• W2159254316 crossrefType "journal-article" @default.
• W2159254316 hasAuthorship W2159254316A5005028382 @default.
• W2159254316 hasAuthorship W2159254316A5011294638 @default.
• W2159254316 hasAuthorship W2159254316A5016882797 @default.
• W2159254316 hasAuthorship W2159254316A5024641774 @default.
• W2159254316 hasAuthorship W2159254316A5032709788 @default.
• W2159254316 hasAuthorship W2159254316A5032826032 @default.
• W2159254316 hasAuthorship W2159254316A5048388392 @default.
• W2159254316 hasAuthorship W2159254316A5050310210 @default.
• W2159254316 hasAuthorship W2159254316A5050515032 @default.
• W2159254316 hasAuthorship W2159254316A5052940866 @default.
• W2159254316 hasAuthorship W2159254316A5090343584 @default.
• W2159254316 hasConcept C104317684 @default.
• W2159254316 hasConcept C142724271 @default.
• W2159254316 hasConcept C148762608 @default.
• W2159254316 hasConcept C153911025 @default.
• W2159254316 hasConcept C169760540 @default.
• W2159254316 hasConcept C185592680 @default.

• next