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• W2159263819 startingPage "15" @default.
• W2159263819 abstract "The Brn-3b POU domain transcription factor is elevated in a significant proportion of breast cancers and in neuroblastoma tumours, where it is associated with increased proliferation, anchorage-independent growth, faster and larger tumour growth in xenograft models, resistance to growth inhibitory stimuli and increased migratory potential. These effects are associated with the ability of Brn-3b to regulate specific genes associated with these processes. Reducing Brn-3b can reverse many of these effects, suggesting that it may be possible to alter the growth and behaviour of tumour cells by abrogating Brn-3b in these cancers. This review discusses the effect of altering Brn-3b in these cancer cells and possible approaches to targeting Brn-3b as a strategy for therapy in treatment of breast cancers." @default.
• W2159263819 created "2016-06-24" @default.
• W2159263819 creator A5002956062 @default.
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• W2159263819 date "2006-01-27" @default.
• W2159263819 modified "2023-10-18" @default.
• W2159263819 title "Targeting Brn-3b in breast cancer therapy" @default.
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• W2159263819 doi "https://doi.org/10.1517/14728222.10.1.15" @default.
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• W2159263819 hasPublicationYear "2006" @default.
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