FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159265075> ?p ?o ?g. }

• W2159265075 endingPage "10580" @default.
• W2159265075 startingPage "10569" @default.
• W2159265075 abstract "Bone marrow stromal antigen 2 (BST-2/tetherin) is a cellular membrane protein that inhibits the release of HIV-1. We show for the first time, using infectious viruses, that BST-2 also inhibits egress of arenaviruses but has no effect on filovirus replication and spread. Specifically, infectious Lassa virus (LASV) release significantly decreased or increased in human cells in which BST-2 was either stably expressed or knocked down, respectively. In contrast, replication and spread of infectious Zaire ebolavirus (ZEBOV) and Lake Victoria marburgvirus (MARV) were not affected by these conditions. Replication of infectious Rift Valley fever virus (RVFV) and cowpox virus (CPXV) was also not affected by BST-2 expression. Elevated cellular levels of human or murine BST-2 inhibited the release of virus-like particles (VLPs) consisting of the matrix proteins of multiple highly virulent NIAID Priority Pathogens, including arenaviruses (LASV and Machupo virus [MACV]), filoviruses (ZEBOV and MARV), and paramyxoviruses (Nipah virus). Although the glycoproteins of filoviruses counteracted the antiviral activity of BST-2 in the context of VLPs, they could not rescue arenaviral (LASV and MACV) VLP release upon BST-2 overexpression. Furthermore, we did not observe colocalization of filoviral glycoproteins with BST-2 during infection with authentic viruses. None of the arenavirus-encoded proteins rescued budding of VLPs in the presence of BST-2. Our results demonstrate that BST-2 might be a broad antiviral factor with the ability to restrict release of a wide variety of human pathogens. However, at least filoviruses, RVFV, and CPXV are immune to its inhibitory effect." @default.
• W2159265075 created "2016-06-24" @default.
• W2159265075 creator A5007492208 @default.
• W2159265075 creator A5008298052 @default.
• W2159265075 creator A5010775046 @default.
• W2159265075 creator A5026212411 @default.
• W2159265075 creator A5030566424 @default.
• W2159265075 creator A5059589132 @default.
• W2159265075 creator A5064135548 @default.
• W2159265075 creator A5066615198 @default.
• W2159265075 creator A5068707910 @default.
• W2159265075 creator A5069996417 @default.
• W2159265075 creator A5072229255 @default.
• W2159265075 creator A5077992307 @default.
• W2159265075 creator A5085274916 @default.
• W2159265075 creator A5086592866 @default.
• W2159265075 creator A5091376183 @default.
• W2159265075 date "2010-10-15" @default.
• W2159265075 modified "2023-10-10" @default.
• W2159265075 title "Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin" @default.
• W2159265075 cites W1492289331 @default.
• W2159265075 cites W1596809034 @default.
• W2159265075 cites W1802597981 @default.
• W2159265075 cites W1898326375 @default.
• W2159265075 cites W1978996068 @default.
• W2159265075 cites W1981692189 @default.
• W2159265075 cites W1989130081 @default.
• W2159265075 cites W1991589508 @default.
• W2159265075 cites W1994436536 @default.
• W2159265075 cites W1999678180 @default.
• W2159265075 cites W2000976084 @default.
• W2159265075 cites W2001430278 @default.
• W2159265075 cites W2010458160 @default.
• W2159265075 cites W2012875512 @default.
• W2159265075 cites W2021067210 @default.
• W2159265075 cites W2021885135 @default.
• W2159265075 cites W2026180733 @default.
• W2159265075 cites W2026406505 @default.
• W2159265075 cites W2026480767 @default.
• W2159265075 cites W2029620587 @default.
• W2159265075 cites W2037024435 @default.
• W2159265075 cites W2042182707 @default.
• W2159265075 cites W2045877830 @default.
• W2159265075 cites W2047452261 @default.
• W2159265075 cites W2050646165 @default.
• W2159265075 cites W2050963689 @default.
• W2159265075 cites W2056923911 @default.
• W2159265075 cites W2058824570 @default.
• W2159265075 cites W2060997082 @default.
• W2159265075 cites W2079843900 @default.
• W2159265075 cites W2082951773 @default.
• W2159265075 cites W2091022868 @default.
• W2159265075 cites W2092267439 @default.
• W2159265075 cites W2094913843 @default.
• W2159265075 cites W2095560925 @default.
• W2159265075 cites W2096284021 @default.
• W2159265075 cites W2096814136 @default.
• W2159265075 cites W2101352435 @default.
• W2159265075 cites W2102537321 @default.
• W2159265075 cites W2108003884 @default.
• W2159265075 cites W2113985215 @default.
• W2159265075 cites W2115665262 @default.
• W2159265075 cites W2116713053 @default.
• W2159265075 cites W2118436036 @default.
• W2159265075 cites W2120231116 @default.
• W2159265075 cites W2127369880 @default.
• W2159265075 cites W2127949919 @default.
• W2159265075 cites W2128782078 @default.
• W2159265075 cites W2130276289 @default.
• W2159265075 cites W2130448025 @default.
• W2159265075 cites W2133682271 @default.
• W2159265075 cites W2136284743 @default.
• W2159265075 cites W2139749521 @default.
• W2159265075 cites W2140699946 @default.
• W2159265075 cites W2143024166 @default.
• W2159265075 cites W2143527074 @default.
• W2159265075 cites W2147579012 @default.
• W2159265075 cites W2147792469 @default.
• W2159265075 cites W2156903285 @default.
• W2159265075 cites W2164439474 @default.
• W2159265075 cites W2171864254 @default.
• W2159265075 cites W4232753812 @default.
• W2159265075 cites W4236672674 @default.
• W2159265075 doi "https://doi.org/10.1128/jvi.00103-10" @default.
• W2159265075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2950602" @default.
• W2159265075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20686043" @default.
• W2159265075 hasPublicationYear "2010" @default.
• W2159265075 type Work @default.
• W2159265075 sameAs 2159265075 @default.
• W2159265075 citedByCount "115" @default.
• W2159265075 countsByYear W21592650752012 @default.
• W2159265075 countsByYear W21592650752013 @default.
• W2159265075 countsByYear W21592650752014 @default.
• W2159265075 countsByYear W21592650752015 @default.
• W2159265075 countsByYear W21592650752016 @default.
• W2159265075 countsByYear W21592650752017 @default.
• W2159265075 countsByYear W21592650752018 @default.
• W2159265075 countsByYear W21592650752019 @default.

• next