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- W2159297820 abstract "IRAS, a putative clone of the I(1)-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif. Receptors with a PRR motif can generally assemble onto multi-element signaling complexes (eg., the beta(3)-receptor on the EGF receptor) and thereby modulate signal transduction. Integrins serve as scaffolds for multi-element signaling complexes, similar to that assembled with the EGF receptor. It is therefore possible that IRAS signals through a complex with other receptors." @default.
- W2159297820 created "2016-06-24" @default.
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- W2159297820 date "2003-12-01" @default.
- W2159297820 modified "2023-09-27" @default.
- W2159297820 title "Assembly of PRR-Containing Receptors on Scaffolds: A Model for Imidazoline I1-Receptor Action" @default.
- W2159297820 doi "https://doi.org/10.1196/annals.1304.055" @default.
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