FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159309468> ?p ?o ?g. }

• W2159309468 endingPage "1820" @default.
• W2159309468 startingPage "1811" @default.
• W2159309468 abstract "Abstract Background: Profiling of the plasma indoles tryptophan, 5-hydroxytryptophan (5-HTP), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA) is useful in the diagnosis and follow-up of patients with carcinoid tumors. We describe an automated method for the profiling of these indoles in protein-containing matrices as well as the plasma indole concentrations in healthy controls and patients with carcinoid tumors. Methods: Plasma, cerebrospinal fluid, and tissue homogenates were prepurified by automated on-line solid-phase extraction (SPE) in Hysphere Resin SH SPE cartridges containing strong hydrophobic polystyrene resin. Analytes were eluted from the SPE cartridge by column switching. Subsequent separation and detection were performed by reversed-phase HPLC combined with fluorometric detection in a total cycle time of 20 min. We obtained samples from 14 healthy controls and 17 patients with metastasized midgut carcinoid tumors for plasma indole analysis. In the patient group, urinary excretion of 5-HIAA and serotonin was compared with concentrations of plasma indoles. Results: Within- and between-series CVs for indoles in platelet-rich plasma were 0.6–6.2% and 3.7–12%, respectively. Results for platelet-rich plasma serotonin compared favorably with those obtained by single-component analysis. Plasma 5-HIAA, but not 5-HTP was detectable in 8 of 17 patients with carcinoid tumors. In the patient group, platelet-rich plasma total tryptophan correlated negatively with platelet-rich plasma serotonin (P = 0.021; r = −0.56), urinary 5-HIAA (P = 0.003; r = −0.68), and urinary serotonin (P &lt;0.0001; r = −0.80). Conclusions: The present chromatographic approach reduces analytical variation and time needed for analysis and gives more detailed information about metabolic deviations in indole metabolism than do manual, single-component analyses." @default.
• W2159309468 created "2016-06-24" @default.
• W2159309468 creator A5019197669 @default.
• W2159309468 creator A5026985405 @default.
• W2159309468 creator A5031042581 @default.
• W2159309468 creator A5061575449 @default.
• W2159309468 creator A5064938073 @default.
• W2159309468 creator A5078581728 @default.
• W2159309468 date "2001-10-01" @default.
• W2159309468 modified "2023-10-07" @default.
• W2159309468 title "Profiling of Tryptophan-related Plasma Indoles in Patients with Carcinoid Tumors by Automated, On-Line, Solid-Phase Extraction and HPLC with Fluorescence Detection" @default.
• W2159309468 cites W1832224854 @default.
• W2159309468 cites W1921789399 @default.
• W2159309468 cites W1927773777 @default.
• W2159309468 cites W1934218182 @default.
• W2159309468 cites W1939945036 @default.
• W2159309468 cites W1945213263 @default.
• W2159309468 cites W1948081655 @default.
• W2159309468 cites W1953007970 @default.
• W2159309468 cites W1964872316 @default.
• W2159309468 cites W1977912428 @default.
• W2159309468 cites W1978979627 @default.
• W2159309468 cites W1981840618 @default.
• W2159309468 cites W1982023276 @default.
• W2159309468 cites W1988344510 @default.
• W2159309468 cites W2000346271 @default.
• W2159309468 cites W2039303232 @default.
• W2159309468 cites W2041118258 @default.
• W2159309468 cites W2041246499 @default.
• W2159309468 cites W2048681529 @default.
• W2159309468 cites W2065104839 @default.
• W2159309468 cites W2067141094 @default.
• W2159309468 cites W2067241332 @default.
• W2159309468 cites W2075220714 @default.
• W2159309468 cites W2101632061 @default.
• W2159309468 cites W2154588018 @default.
• W2159309468 cites W2161932072 @default.
• W2159309468 cites W2334372885 @default.
• W2159309468 doi "https://doi.org/10.1093/clinchem/47.10.1811" @default.
• W2159309468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11568091" @default.
• W2159309468 hasPublicationYear "2001" @default.
• W2159309468 type Work @default.
• W2159309468 sameAs 2159309468 @default.
• W2159309468 citedByCount "91" @default.
• W2159309468 countsByYear W21593094682012 @default.
• W2159309468 countsByYear W21593094682013 @default.
• W2159309468 countsByYear W21593094682014 @default.
• W2159309468 countsByYear W21593094682015 @default.
• W2159309468 countsByYear W21593094682016 @default.
• W2159309468 countsByYear W21593094682017 @default.
• W2159309468 countsByYear W21593094682018 @default.
• W2159309468 countsByYear W21593094682019 @default.
• W2159309468 countsByYear W21593094682020 @default.
• W2159309468 countsByYear W21593094682021 @default.
• W2159309468 countsByYear W21593094682022 @default.
• W2159309468 crossrefType "journal-article" @default.
• W2159309468 hasAuthorship W2159309468A5019197669 @default.
• W2159309468 hasAuthorship W2159309468A5026985405 @default.
• W2159309468 hasAuthorship W2159309468A5031042581 @default.
• W2159309468 hasAuthorship W2159309468A5061575449 @default.
• W2159309468 hasAuthorship W2159309468A5064938073 @default.
• W2159309468 hasAuthorship W2159309468A5078581728 @default.
• W2159309468 hasBestOaLocation W21593094681 @default.
• W2159309468 hasConcept C10390740 @default.
• W2159309468 hasConcept C126322002 @default.
• W2159309468 hasConcept C134018914 @default.
• W2159309468 hasConcept C170493617 @default.
• W2159309468 hasConcept C179998833 @default.
• W2159309468 hasConcept C185592680 @default.
• W2159309468 hasConcept C2775864247 @default.
• W2159309468 hasConcept C2776575606 @default.
• W2159309468 hasConcept C2776706248 @default.
• W2159309468 hasConcept C2778506435 @default.
• W2159309468 hasConcept C2779164789 @default.
• W2159309468 hasConcept C2781151469 @default.
• W2159309468 hasConcept C43617362 @default.
• W2159309468 hasConcept C515207424 @default.
• W2159309468 hasConcept C55493867 @default.
• W2159309468 hasConcept C71924100 @default.
• W2159309468 hasConcept C81426234 @default.
• W2159309468 hasConcept C89560881 @default.
• W2159309468 hasConceptScore W2159309468C10390740 @default.
• W2159309468 hasConceptScore W2159309468C126322002 @default.
• W2159309468 hasConceptScore W2159309468C134018914 @default.
• W2159309468 hasConceptScore W2159309468C170493617 @default.
• W2159309468 hasConceptScore W2159309468C179998833 @default.
• W2159309468 hasConceptScore W2159309468C185592680 @default.
• W2159309468 hasConceptScore W2159309468C2775864247 @default.
• W2159309468 hasConceptScore W2159309468C2776575606 @default.
• W2159309468 hasConceptScore W2159309468C2776706248 @default.
• W2159309468 hasConceptScore W2159309468C2778506435 @default.
• W2159309468 hasConceptScore W2159309468C2779164789 @default.
• W2159309468 hasConceptScore W2159309468C2781151469 @default.
• W2159309468 hasConceptScore W2159309468C43617362 @default.
• W2159309468 hasConceptScore W2159309468C515207424 @default.
• W2159309468 hasConceptScore W2159309468C55493867 @default.
• W2159309468 hasConceptScore W2159309468C71924100 @default.
• W2159309468 hasConceptScore W2159309468C81426234 @default.

• next