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• W2159330262 abstract "Abstract Aim A systematic analysis was conducted of trials comparing the effectiveness of transanal endoscopic microsurgery ( TEMS ) with radical resection ( RR ) for T 1 and T 2 rectal cancer. Method An electronic search was carried out of trials reporting the effectiveness of TEMS and RR in the treatment of T 1 and T 2 rectal cancers. Results Ten trials including 942 patients were retrieved. There was a trend toward a higher risk of local recurrence (odds ratio 2.78; 95% confidence interval 1.42, 5.44; z = 2.97; P < 0.003) and overall recurrence ( P < 0.01) following TEMS compared with RR . The risk of distant recurrence, overall survival (odds ratio 0.90; 95% confidence interval 0.49, 1.66; z = 0.33; P = 0.74) and mortality was similar. TEMS was associated with a shorter operation time and hospital stay and a reduced risk of postoperative complications ( P < 0.0001). The included studies, however, were significantly diverse in stage and grade of rectal cancer and the use of neoadjuvant chemoradiotherapy. Conclusion Transanal endoscopic microsurgery appears to have clinically measurable advantages in patients with early rectal cancer. The studies included in this review do not allow firm conclusions as to whether TEMS is superior to RR in the management of early rectal cancer. Larger, better designed and executed prospective studies are needed to answer this question." @default.
• W2159330262 created "2016-06-24" @default.
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• W2159330262 date "2013-12-16" @default.
• W2159330262 modified "2023-10-07" @default.
• W2159330262 title "Systematic review and meta‐analysis of published trials comparing the effectiveness of transanal endoscopic microsurgery and radical resection in the management of early rectal cancer" @default.
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• W2159330262 doi "https://doi.org/10.1111/codi.12474" @default.
• W2159330262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24330432" @default.
• W2159330262 hasPublicationYear "2013" @default.
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