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- W2159353556 abstract "The co-ordinated expression of virulence factors is a critical process for any bacterial pathogen to colonize its host. Here we investigated the mechanisms of niche adaptation of the zoonotic pathogen Bartonella henselae by combining genetic approaches and shotgun proteomics. We demonstrated that expression of the VirB/D4 type IV secretion system (T4SS) and its secreted effector proteins require the alternative sigma factor RpoH1, which levels are controlled by the stringent response (SR) components DksA and SpoT. The RpoH1-dependent activation requires an active BatR/BatS two-component system (TCS) while BatR expression is controlled by RpoH1 and the SR components. Deletion of spoT results in a strong attenuation of VirB/D4 T4SS expression whereas dksA, rpoH1 or batR deletion fully abolishes its activity. In contrast to their activating effect on the VirB/D4 T4SS, which is critical at the early stage of host infection, SpoT and DksA negatively regulate the Trw T4SS, which mediates host-specific erythrocyte infection at a later stage of the colonization process. Our findings support a model where the SR signalling and the physiological pH-induced BatR/BatS TCS conjointly control the spatiotemporal expression of B. henselae adaptation factors during host infection." @default.
- W2159353556 created "2016-06-24" @default.
- W2159353556 creator A5003790381 @default.
- W2159353556 creator A5018962844 @default.
- W2159353556 creator A5079560105 @default.
- W2159353556 creator A5087874713 @default.
- W2159353556 creator A5089448977 @default.
- W2159353556 date "2013-10-04" @default.
- W2159353556 modified "2023-09-24" @default.
- W2159353556 title "Dual input control: activation of the<i>Bartonella henselae</i> VirB/D4 type IV secretion system by the stringent sigma factor RpoH1 and the BatR/BatS two-component system" @default.
- W2159353556 cites W1490437964 @default.
- W2159353556 cites W1502916179 @default.
- W2159353556 cites W1852979501 @default.
- W2159353556 cites W1941962498 @default.
- W2159353556 cites W1952722535 @default.
- W2159353556 cites W1964979713 @default.
- W2159353556 cites W1966074478 @default.
- W2159353556 cites W1971507610 @default.
- W2159353556 cites W1972520421 @default.
- W2159353556 cites W1976486696 @default.
- W2159353556 cites W1976806781 @default.
- W2159353556 cites W1980751665 @default.
- W2159353556 cites W1983767314 @default.
- W2159353556 cites W1984284836 @default.
- W2159353556 cites W1993372010 @default.
- W2159353556 cites W1997528669 @default.
- W2159353556 cites W1998091295 @default.
- W2159353556 cites W2012840944 @default.
- W2159353556 cites W2014982379 @default.
- W2159353556 cites W2016814816 @default.
- W2159353556 cites W2019991821 @default.
- W2159353556 cites W2022926885 @default.
- W2159353556 cites W2023359102 @default.
- W2159353556 cites W2025265211 @default.
- W2159353556 cites W2036408239 @default.
- W2159353556 cites W2040155859 @default.
- W2159353556 cites W2040960801 @default.
- W2159353556 cites W2044924241 @default.
- W2159353556 cites W2047733883 @default.
- W2159353556 cites W2056592058 @default.
- W2159353556 cites W2058979757 @default.
- W2159353556 cites W2059513932 @default.
- W2159353556 cites W2065298603 @default.
- W2159353556 cites W2067092006 @default.
- W2159353556 cites W2067477145 @default.
- W2159353556 cites W2067613735 @default.
- W2159353556 cites W2073828648 @default.
- W2159353556 cites W2076137350 @default.
- W2159353556 cites W2078808594 @default.
- W2159353556 cites W2082876993 @default.
- W2159353556 cites W2091915244 @default.
- W2159353556 cites W2092941764 @default.
- W2159353556 cites W2097165693 @default.
- W2159353556 cites W2100580791 @default.
- W2159353556 cites W2105422809 @default.
- W2159353556 cites W2111941744 @default.
- W2159353556 cites W2115506067 @default.
- W2159353556 cites W2118522962 @default.
- W2159353556 cites W2120423879 @default.
- W2159353556 cites W2121915577 @default.
- W2159353556 cites W2122301597 @default.
- W2159353556 cites W2123137137 @default.
- W2159353556 cites W2123402293 @default.
- W2159353556 cites W2124926742 @default.
- W2159353556 cites W2128009182 @default.
- W2159353556 cites W2128250684 @default.
- W2159353556 cites W2128974582 @default.
- W2159353556 cites W2129538546 @default.
- W2159353556 cites W2131337742 @default.
- W2159353556 cites W2132529453 @default.
- W2159353556 cites W2132957039 @default.
- W2159353556 cites W2133271206 @default.
- W2159353556 cites W2135144856 @default.
- W2159353556 cites W2135398184 @default.
- W2159353556 cites W2144569138 @default.
- W2159353556 cites W2146088499 @default.
- W2159353556 cites W2146120613 @default.
- W2159353556 cites W2146997836 @default.
- W2159353556 cites W2148111565 @default.
- W2159353556 cites W2149990334 @default.
- W2159353556 cites W2152923355 @default.
- W2159353556 cites W2154669392 @default.
- W2159353556 cites W2157918066 @default.
- W2159353556 cites W2159165131 @default.
- W2159353556 cites W2162122989 @default.
- W2159353556 cites W2162181580 @default.
- W2159353556 cites W2162368409 @default.
- W2159353556 cites W2162376398 @default.
- W2159353556 cites W2164176738 @default.
- W2159353556 cites W2164266771 @default.
- W2159353556 cites W2166319413 @default.
- W2159353556 cites W2169586133 @default.
- W2159353556 cites W2170887801 @default.
- W2159353556 cites W2171451207 @default.
- W2159353556 doi "https://doi.org/10.1111/mmi.12396" @default.
- W2159353556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24033511" @default.
- W2159353556 hasPublicationYear "2013" @default.
- W2159353556 type Work @default.