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• W2159355466 startingPage "7128" @default.
• W2159355466 abstract "The ionotropic and cytolytic P2X 7 receptor is typically found on immune cells, where it is involved in the release of cytokines. Recently, P2X 7 receptors were reported to be localized to presynaptic nerve terminals and to modulate transmitter release. In the present study, we reassessed this unexpected role of P2X 7 receptors at hippocampal mossy fiber-CA3 synapses. In agreement with previous findings, the widely used P2X 7 agonist 2′-3′- O -(4-benzoylbenzoyl)-adenosine-5′-triphosphate (BzATP) clearly depressed field potentials (fEPSPs); however, no evidence for an involvement of P2X 7 receptors could be obtained. First, depression of fEPSPs by BzATP was unchanged in P2X 7 -/- mice. Second, experiments using P2X 7 -/- mice, immunohistochemistry, and electron microscopy showed that the antigen detected by frequently used P2X 7 antibodies is not compatible with a plasmalemmal P2X 7 receptor. Third, BzATP did not alter Ca 2+ levels in synaptic terminals. In contrast, the depression of fEPSPs by BzATP was fully blocked by adenosine (A 1 ) receptor antagonists. Furthermore, the application of BzATP also activated postsynaptic A 1 receptor-coupled K + channels. This effect of BzATP was mimicked by ATP and adenosine and was completely prevented by enzymes specifically degrading adenosine. Activation of A 1 -coupled K + channels by BzATP was dependent on ecto-nucleotidases, extracellular enzymes that convert ATP to adenosine. Moreover, the opening of A 1 -coupled K + channels by BzATP was dependent on nucleoside transporters. Taken together, our results indicate that BzATP is extracellularly catabolized to Bz-adenosine and subsequently hetero-exchanged for intracellular adenosine and then depresses mossy fiber fEPSPs through presynaptic A 1 receptors rather than through P2X 7 receptors. Thus, the present study casts doubts on the neuronal localization of P2X 7 receptors in rodent hippocampus." @default.
• W2159355466 created "2016-06-24" @default.
• W2159355466 creator A5000300585 @default.
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• W2159355466 creator A5033497484 @default.
• W2159355466 creator A5036338186 @default.
• W2159355466 creator A5044285027 @default.
• W2159355466 date "2004-08-11" @default.
• W2159355466 modified "2023-10-17" @default.
• W2159355466 title "Ecto-Nucleotidases and Nucleoside Transporters Mediate Activation of Adenosine Receptors on Hippocampal Mossy Fibers by P2X₇Receptor Agonist 2′-3′-<i>O</i>-(4-Benzoylbenzoyl)-ATP" @default.
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• W2159355466 doi "https://doi.org/10.1523/jneurosci.2093-04.2004" @default.
• W2159355466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6729177" @default.
• W2159355466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15306646" @default.
• W2159355466 hasPublicationYear "2004" @default.

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