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- W2159372753 abstract "Proliferation decreases in the neurogenic subventricular zone (SVZ) of mice after aspiration lesions of the cerebral cortex. We hypothesized that microglial activation may contribute to this given microglial activation attenuates neurogenesis in the hippocampus. Using CD45, CD11b, IB4, and IL-6 immunohistochemistry (IHC), BrdU IHC, and fluorescent bead tracking of peripheral monocytes into the brain, we compared microglial activation in the SVZ to non-neurogenic forebrain regions. SVZ microglia exhibited greater constitutive activation and proliferation than did microglia in non-neurogenic regions. In contrast to the SVZ, the dentate gyrus (DG) contained relatively few CD45(+) cells. After aspiration cerebral cortex lesions, microglia became activated in the cerebral cortex, corpus callosum, and striatum. SVZ microglial activation did not increase, and similarly, microglia in the DG were less activated after injury than in adjacent non-neurogenic regions. We next showed that SVZ microglia are not categorically refractory to activation, since deep cortical contusion injuries increased SVZ microglial activation. Macrophages migrate into the brain during development, but it is unclear if this is recapitulated after injury. Infiltration of microbead-labeled macrophages into the brain did not change after injury, but resident SVZ microglia were induced to migrate toward the injury. Our data show that both constitutive and postlesion levels of microglial activation differ between neurogenic and non-neurogenic regions." @default.
- W2159372753 created "2016-06-24" @default.
- W2159372753 creator A5010088048 @default.
- W2159372753 creator A5024419404 @default.
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- W2159372753 date "2006-07-21" @default.
- W2159372753 modified "2023-10-14" @default.
- W2159372753 title "Differential activation of microglia in neurogenic versus non-neurogenic regions of the forebrain" @default.
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- W2159372753 cites W1600123087 @default.
- W2159372753 cites W1611449349 @default.
- W2159372753 cites W1778136690 @default.
- W2159372753 cites W183710148 @default.
- W2159372753 cites W1859730138 @default.
- W2159372753 cites W1966820714 @default.
- W2159372753 cites W1968424090 @default.
- W2159372753 cites W1980228038 @default.
- W2159372753 cites W1982076869 @default.
- W2159372753 cites W1982850249 @default.
- W2159372753 cites W1983955843 @default.
- W2159372753 cites W1985958166 @default.
- W2159372753 cites W1988044590 @default.
- W2159372753 cites W1989720162 @default.
- W2159372753 cites W2000217512 @default.
- W2159372753 cites W2000535898 @default.
- W2159372753 cites W2004590336 @default.
- W2159372753 cites W2005848913 @default.
- W2159372753 cites W2007242343 @default.
- W2159372753 cites W2013774253 @default.
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- W2159372753 cites W2021442315 @default.
- W2159372753 cites W2022734136 @default.
- W2159372753 cites W2025326202 @default.
- W2159372753 cites W2047575104 @default.
- W2159372753 cites W2048699935 @default.
- W2159372753 cites W2049587223 @default.
- W2159372753 cites W2050707975 @default.
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- W2159372753 cites W2057889993 @default.
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- W2159372753 cites W2075463100 @default.
- W2159372753 cites W2076407459 @default.
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- W2159372753 cites W2128278918 @default.
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- W2159372753 cites W2139450672 @default.
- W2159372753 cites W2146394305 @default.
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- W2159372753 doi "https://doi.org/10.1002/glia.20381" @default.
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