FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159375095> ?p ?o ?g. }

• W2159375095 endingPage "482" @default.
• W2159375095 startingPage "476" @default.
• W2159375095 abstract "Nevirapine is widely used for the treatment of HIV-1 infection; however, its chronic use has been associated with severe liver and skin toxicity. Women are at increased risk for these toxic events, but the reasons for the sex-related differences are unclear. Disparities in the biotransformation of nevirapine and the generation of toxic metabolites between men and women might be the underlying cause. The present work aimed to explore sex differences in nevirapine biotransformation as a potential factor in nevirapine-induced toxicity. All included subjects were adults who had been receiving 400 mg of nevirapine once daily for at least 1 month. Blood samples were collected and the levels of nevirapine and its phase I metabolites were quantified by HPLC. Anthropometric and clinical data, and nevirapine metabolite profiles, were assessed for sex-related differences. A total of 52 patients were included (63% were men). Body weight was lower in women (P = 0.028) and female sex was associated with higher alkaline phosphatase (P = 0.036) and lactate dehydrogenase (P = 0.037) levels. The plasma concentrations of nevirapine (P = 0.030) and the metabolite 3-hydroxy-nevirapine (P = 0.035), as well as the proportions of the metabolites 12-hydroxy-nevirapine (P = 0.037) and 3-hydroxy-nevirapine (P = 0.001), were higher in women, when adjusted for body weight. There was a sex-dependent variation in nevirapine biotransformation, particularly in the generation of the 12-hydroxy-nevirapine and 3-hydroxy-nevirapine metabolites. These data are consistent with the sex-dependent formation of toxic reactive metabolites, which may contribute to the sex-dependent dimorphic profile of nevirapine toxicity." @default.
• W2159375095 created "2016-06-24" @default.
• W2159375095 creator A5000220692 @default.
• W2159375095 creator A5015034643 @default.
• W2159375095 creator A5022160469 @default.
• W2159375095 creator A5026013020 @default.
• W2159375095 creator A5053568158 @default.
• W2159375095 creator A5058622754 @default.
• W2159375095 creator A5076501395 @default.
• W2159375095 creator A5077946706 @default.
• W2159375095 creator A5079250439 @default.
• W2159375095 date "2013-09-19" @default.
• W2159375095 modified "2023-10-03" @default.
• W2159375095 title "Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions" @default.
• W2159375095 cites W1517597567 @default.
• W2159375095 cites W1556631311 @default.
• W2159375095 cites W1940770670 @default.
• W2159375095 cites W1964732626 @default.
• W2159375095 cites W1967053505 @default.
• W2159375095 cites W1968985349 @default.
• W2159375095 cites W1987194351 @default.
• W2159375095 cites W1990665707 @default.
• W2159375095 cites W1991082659 @default.
• W2159375095 cites W1994872511 @default.
• W2159375095 cites W1996946369 @default.
• W2159375095 cites W2001612919 @default.
• W2159375095 cites W2005553692 @default.
• W2159375095 cites W2006152917 @default.
• W2159375095 cites W2009080279 @default.
• W2159375095 cites W2011720238 @default.
• W2159375095 cites W2015229578 @default.
• W2159375095 cites W2018158288 @default.
• W2159375095 cites W2028282799 @default.
• W2159375095 cites W2036796228 @default.
• W2159375095 cites W2042662422 @default.
• W2159375095 cites W2046004957 @default.
• W2159375095 cites W2048276534 @default.
• W2159375095 cites W2051793219 @default.
• W2159375095 cites W2057304619 @default.
• W2159375095 cites W2058627164 @default.
• W2159375095 cites W2063093761 @default.
• W2159375095 cites W2067351036 @default.
• W2159375095 cites W2071578885 @default.
• W2159375095 cites W2072394663 @default.
• W2159375095 cites W2084581206 @default.
• W2159375095 cites W2088282011 @default.
• W2159375095 cites W2092409560 @default.
• W2159375095 cites W2094445330 @default.
• W2159375095 cites W2098563159 @default.
• W2159375095 cites W2105010850 @default.
• W2159375095 cites W2105822011 @default.
• W2159375095 cites W2126506951 @default.
• W2159375095 cites W2127291942 @default.
• W2159375095 cites W2133866312 @default.
• W2159375095 cites W2135826395 @default.
• W2159375095 cites W2139178927 @default.
• W2159375095 cites W2141981971 @default.
• W2159375095 cites W2144150803 @default.
• W2159375095 cites W2148684707 @default.
• W2159375095 cites W2149986609 @default.
• W2159375095 cites W2152214008 @default.
• W2159375095 cites W2152293167 @default.
• W2159375095 cites W2152984392 @default.
• W2159375095 cites W2154703395 @default.
• W2159375095 cites W2155168486 @default.
• W2159375095 cites W2155373527 @default.
• W2159375095 cites W2155882052 @default.
• W2159375095 cites W2164216849 @default.
• W2159375095 cites W2164233023 @default.
• W2159375095 cites W2167794954 @default.
• W2159375095 cites W2314904660 @default.
• W2159375095 cites W2949659406 @default.
• W2159375095 cites W4240153861 @default.
• W2159375095 cites W4245286180 @default.
• W2159375095 doi "https://doi.org/10.1093/jac/dkt359" @default.
• W2159375095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24051761" @default.
• W2159375095 hasPublicationYear "2013" @default.
• W2159375095 type Work @default.
• W2159375095 sameAs 2159375095 @default.
• W2159375095 citedByCount "25" @default.
• W2159375095 countsByYear W21593750952013 @default.
• W2159375095 countsByYear W21593750952014 @default.
• W2159375095 countsByYear W21593750952015 @default.
• W2159375095 countsByYear W21593750952016 @default.
• W2159375095 countsByYear W21593750952017 @default.
• W2159375095 countsByYear W21593750952018 @default.
• W2159375095 countsByYear W21593750952019 @default.
• W2159375095 countsByYear W21593750952020 @default.
• W2159375095 countsByYear W21593750952021 @default.
• W2159375095 countsByYear W21593750952023 @default.
• W2159375095 crossrefType "journal-article" @default.
• W2159375095 hasAuthorship W2159375095A5000220692 @default.
• W2159375095 hasAuthorship W2159375095A5015034643 @default.
• W2159375095 hasAuthorship W2159375095A5022160469 @default.
• W2159375095 hasAuthorship W2159375095A5026013020 @default.
• W2159375095 hasAuthorship W2159375095A5053568158 @default.
• W2159375095 hasAuthorship W2159375095A5058622754 @default.
• W2159375095 hasAuthorship W2159375095A5076501395 @default.

• next