FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2159379075> ?p ?o ?g. }

• W2159379075 endingPage "1373" @default.
• W2159379075 startingPage "1364" @default.
• W2159379075 abstract "In this study, we report the isolation and characterization of a full-length cDNA clone for the hormone-inducible regulatory subunit RII beta (formerly called RII51) of type II cAMP-dependent protein kinase from a human testis cDNA library. The cloned cDNA demonstrated tissue-specific expression of RII beta mRNA in human tissues, with the highest mRNA levels in testis and ovary. The isolated human cDNA clone was 3.3 kilobases (kb) in length and contained 166 base pairs (bp) of G/C-rich 5'-noncoding sequence, an open reading frame of 1254 bp and an A/T-rich 3'-nontranslated region containing 1836 bp followed by an 89 nucleotide long poly(A)-tail. The predicted protein contains 418 amino acids including the start methionine, and the estimated mol wt of human RII beta is 53,856. The nucleotide sequence within the open reading frame and the predicted amino acid sequence of human RII beta are highly conserved compared with partial rat RII beta sequences, displaying 91% and 97% similarity, respectively. Codon preference analysis of the cloned cDNA sequence indicated that the two cAMP-binding domains and the hinge region are highly conserved through evolution, whereas the dimerization domain displayed a codon preference pattern indicative of appearance at a later stage of evolution. The isolated human cDNA detected an FSH- and cAMP-inducible mRNA of 3.2 kb in rat Sertoli cells, thus confirming that the cloned cDNA represents the hormone-inducible regulatory subunit of cAMP-dependent protein kinase. This is the first report documenting the isolation of a full-length cDNA clone for the RII beta of cAMP-dependent protein kinase." @default.
• W2159379075 created "2016-06-24" @default.
• W2159379075 creator A5012152899 @default.
• W2159379075 creator A5015106218 @default.
• W2159379075 creator A5042045668 @default.
• W2159379075 creator A5042436798 @default.
• W2159379075 creator A5042862730 @default.
• W2159379075 creator A5074651276 @default.
• W2159379075 creator A5089161978 @default.
• W2159379075 date "1988-12-01" @default.
• W2159379075 modified "2023-09-26" @default.
• W2159379075 title "Molecular Cloning, Complementary Deoxyribonucleic Acid Structure and Predicted Full-Length Amino Acid Sequence of the Hormone-lnducible Regulatory Subunit of 3′-5′-Cyclic Adenosine Monophosphate-Dependent Protein Kinase from Human Testis" @default.
• W2159379075 cites W1521885531 @default.
• W2159379075 cites W1537203265 @default.
• W2159379075 cites W1570227839 @default.
• W2159379075 cites W1573237423 @default.
• W2159379075 cites W1576381397 @default.
• W2159379075 cites W1580216379 @default.
• W2159379075 cites W1589074645 @default.
• W2159379075 cites W1590670067 @default.
• W2159379075 cites W1607359458 @default.
• W2159379075 cites W1664487761 @default.
• W2159379075 cites W1853709009 @default.
• W2159379075 cites W1965457335 @default.
• W2159379075 cites W1969994632 @default.
• W2159379075 cites W1970042526 @default.
• W2159379075 cites W1990862775 @default.
• W2159379075 cites W1996654407 @default.
• W2159379075 cites W2000329288 @default.
• W2159379075 cites W2009310436 @default.
• W2159379075 cites W2010511920 @default.
• W2159379075 cites W2022097938 @default.
• W2159379075 cites W2038688425 @default.
• W2159379075 cites W2042149904 @default.
• W2159379075 cites W2044737968 @default.
• W2159379075 cites W2045348184 @default.
• W2159379075 cites W2045811908 @default.
• W2159379075 cites W2046291479 @default.
• W2159379075 cites W2047521874 @default.
• W2159379075 cites W2053892984 @default.
• W2159379075 cites W2054698853 @default.
• W2159379075 cites W2060333964 @default.
• W2159379075 cites W2064741419 @default.
• W2159379075 cites W2074231493 @default.
• W2159379075 cites W2092030043 @default.
• W2159379075 cites W2138270253 @default.
• W2159379075 cites W2144634347 @default.
• W2159379075 cites W2409484155 @default.
• W2159379075 doi "https://doi.org/10.1210/mend-2-12-1364" @default.
• W2159379075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2851102" @default.
• W2159379075 hasPublicationYear "1988" @default.
• W2159379075 type Work @default.
• W2159379075 sameAs 2159379075 @default.
• W2159379075 citedByCount "121" @default.
• W2159379075 countsByYear W21593790752012 @default.
• W2159379075 crossrefType "journal-article" @default.
• W2159379075 hasAuthorship W2159379075A5012152899 @default.
• W2159379075 hasAuthorship W2159379075A5015106218 @default.
• W2159379075 hasAuthorship W2159379075A5042045668 @default.
• W2159379075 hasAuthorship W2159379075A5042436798 @default.
• W2159379075 hasAuthorship W2159379075A5042862730 @default.
• W2159379075 hasAuthorship W2159379075A5074651276 @default.
• W2159379075 hasAuthorship W2159379075A5089161978 @default.
• W2159379075 hasBestOaLocation W21593790751 @default.
• W2159379075 hasConcept C104317684 @default.
• W2159379075 hasConcept C105580179 @default.
• W2159379075 hasConcept C153911025 @default.
• W2159379075 hasConcept C167625842 @default.
• W2159379075 hasConcept C187882448 @default.
• W2159379075 hasConcept C189482833 @default.
• W2159379075 hasConcept C47289529 @default.
• W2159379075 hasConcept C50724178 @default.
• W2159379075 hasConcept C55493867 @default.
• W2159379075 hasConcept C84148353 @default.
• W2159379075 hasConcept C86803240 @default.
• W2159379075 hasConceptScore W2159379075C104317684 @default.
• W2159379075 hasConceptScore W2159379075C105580179 @default.
• W2159379075 hasConceptScore W2159379075C153911025 @default.
• W2159379075 hasConceptScore W2159379075C167625842 @default.
• W2159379075 hasConceptScore W2159379075C187882448 @default.
• W2159379075 hasConceptScore W2159379075C189482833 @default.
• W2159379075 hasConceptScore W2159379075C47289529 @default.
• W2159379075 hasConceptScore W2159379075C50724178 @default.
• W2159379075 hasConceptScore W2159379075C55493867 @default.
• W2159379075 hasConceptScore W2159379075C84148353 @default.
• W2159379075 hasConceptScore W2159379075C86803240 @default.
• W2159379075 hasIssue "12" @default.
• W2159379075 hasLocation W21593790751 @default.
• W2159379075 hasLocation W21593790752 @default.
• W2159379075 hasOpenAccess W2159379075 @default.
• W2159379075 hasPrimaryLocation W21593790751 @default.
• W2159379075 hasRelatedWork W1559584022 @default.
• W2159379075 hasRelatedWork W1803589382 @default.
• W2159379075 hasRelatedWork W1966427723 @default.
• W2159379075 hasRelatedWork W1979663996 @default.
• W2159379075 hasRelatedWork W2009810944 @default.
• W2159379075 hasRelatedWork W2020645742 @default.
• W2159379075 hasRelatedWork W2020705567 @default.

• next