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• W2159380046 abstract "Homeostatic regulation of spine number in mature hippocampal neurons results in more dendritic spines when synaptic transmission is blocked, providing a mechanism to compensate for diminished synaptic input. It is unsettled whether blockade of synaptic transmission also elevates spine number during development. To address this question, synaptic transmission was blocked in rat hippocampal slices during critical developmental stages of spine formation at postnatal days (P) 6–P22 and compared to adults. CA1 pyramidal cells were labeled with DiI and maintained for 5 h in one of three conditions, control artificial cerebrospinal fluid (ACSF), block media containing synaptic transmission antagonists in ACSF, or block media containing synaptic transmission antagonists in a nominally calcium-free ACSF with high magnesium. Slices were fixed in mixed aldehydes, sectioned, and the lateral dendrites were imaged in stratum radiatum with confocal microscopy. Dendritic spine density was quantified per unit length of dendrite. At P6–7 there were only a few protrusions emerging from the dendrites, which were predominantly filopodia-like in appearance. At both P11–12 and P15–16 there was a mixture of dendritic spines and filopodia-like structures. By P20–22 dendritic spines predominated and spine density was about 82% of the adult level. Dendritic spine density increased during blocked synaptic transmission at P20–22 as in adults, but was unchanged during blockade at younger ages. When extracellular calcium was nominally zero, dendritic spine density further increased on P20–22 dendrites as in adults. In contrast, spine density decreased along P11–12 dendrites under the nominally zero calcium condition. Under control conditions, dendritic protrusions were longer at P6–7 than at all other ages, which did not differ from one another. When synaptic transmission was blocked, dendritic protrusions further elongated at P6–7 only. Under the nominally zero calcium condition with blocked synaptic transmission, dendritic protrusions shortened at P11–12 only. These findings reveal age-dependent changes in the manifestation of homeostatic control of dendritic spines that could be mediated by maturational changes in mechanisms regulating postsynaptic calcium." @default.
• W2159380046 created "2016-06-24" @default.
• W2159380046 creator A5037938897 @default.
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• W2159380046 date "2004-10-01" @default.
• W2159380046 modified "2023-10-18" @default.
• W2159380046 title "Age-dependence in the homeostatic upregulation of hippocampal dendritic spine number during blocked synaptic transmission" @default.
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• W2159380046 cites W1564467813 @default.
• W2159380046 cites W1571022725 @default.
• W2159380046 cites W1572640432 @default.
• W2159380046 cites W1587505135 @default.
• W2159380046 cites W1592516385 @default.
• W2159380046 cites W1642243794 @default.
• W2159380046 cites W1647836033 @default.
• W2159380046 cites W1677457722 @default.
• W2159380046 cites W1762016765 @default.
• W2159380046 cites W1796802340 @default.
• W2159380046 cites W1834463603 @default.
• W2159380046 cites W1848474885 @default.
• W2159380046 cites W1963806203 @default.
• W2159380046 cites W1963963602 @default.
• W2159380046 cites W1966620194 @default.
• W2159380046 cites W1966991127 @default.
• W2159380046 cites W1975782461 @default.
• W2159380046 cites W1979246511 @default.
• W2159380046 cites W1990421253 @default.
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• W2159380046 cites W2019106988 @default.
• W2159380046 cites W2033087539 @default.
• W2159380046 cites W2037921808 @default.
• W2159380046 cites W2038902819 @default.
• W2159380046 cites W2039508969 @default.
• W2159380046 cites W2040003929 @default.
• W2159380046 cites W2042183685 @default.
• W2159380046 cites W2045808315 @default.
• W2159380046 cites W2049066962 @default.
• W2159380046 cites W2049511526 @default.
• W2159380046 cites W2063062105 @default.
• W2159380046 cites W2066781880 @default.
• W2159380046 cites W2076837924 @default.
• W2159380046 cites W2079133060 @default.
• W2159380046 cites W2080611091 @default.
• W2159380046 cites W2088984430 @default.
• W2159380046 cites W2096918711 @default.
• W2159380046 cites W2098017117 @default.
• W2159380046 cites W2103762808 @default.
• W2159380046 cites W2104180981 @default.
• W2159380046 cites W2112075984 @default.
• W2159380046 cites W2113122815 @default.
• W2159380046 cites W2113189368 @default.
• W2159380046 cites W2114934533 @default.
• W2159380046 cites W2122037734 @default.
• W2159380046 cites W2126033680 @default.
• W2159380046 cites W2126250161 @default.
• W2159380046 cites W2127861262 @default.
• W2159380046 cites W2130183688 @default.
• W2159380046 cites W2134863448 @default.
• W2159380046 cites W2139528091 @default.
• W2159380046 cites W2143418370 @default.
• W2159380046 cites W2147715586 @default.
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• W2159380046 cites W2152371902 @default.
• W2159380046 cites W2156678388 @default.
• W2159380046 cites W2157238829 @default.
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• W2159380046 cites W2242792050 @default.
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• W2159380046 doi "https://doi.org/10.1016/j.neuropharm.2004.07.039" @default.
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• W2159380046 hasPublicationYear "2004" @default.
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